Neuronal SKN-1B modulates nutritional signalling pathways and mitochondrial networks to control satiety.
The feeling of hunger or satiety results from integration of the sensory nervous system with other physiological and metabolic cues. This regulates food intake, maintains homeostasis and prevents disease. In C. elegans, chemosensory neurons sense food and relay information to the rest of the animal...
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2021-03-01
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Series: | PLoS Genetics |
Online Access: | https://doi.org/10.1371/journal.pgen.1009358 |
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doaj-0bb85b752bff472e9c3efefb74bab50c2021-08-05T04:32:24ZengPublic Library of Science (PLoS)PLoS Genetics1553-73901553-74042021-03-01173e100935810.1371/journal.pgen.1009358Neuronal SKN-1B modulates nutritional signalling pathways and mitochondrial networks to control satiety.Nikolaos Tataridas-PallasMaximillian A ThompsonAlexander HowardIan BrownMarina EzcurraZiyun WuIsabel Goncalves SilvaChristopher D SaunterTimo KuertenDavid WeinkoveT Keith BlackwellJennifer M A TulletThe feeling of hunger or satiety results from integration of the sensory nervous system with other physiological and metabolic cues. This regulates food intake, maintains homeostasis and prevents disease. In C. elegans, chemosensory neurons sense food and relay information to the rest of the animal via hormones to control food-related behaviour and physiology. Here we identify a new component of this system, SKN-1B which acts as a central food-responsive node, ultimately controlling satiety and metabolic homeostasis. SKN-1B, an ortholog of mammalian NF-E2 related transcription factors (Nrfs), has previously been implicated with metabolism, respiration and the increased lifespan incurred by dietary restriction. Here we show that SKN-1B acts in two hypothalamus-like ASI neurons to sense food, communicate nutritional status to the organism, and control satiety and exploratory behaviours. This is achieved by SKN-1B modulating endocrine signalling pathways (IIS and TGF-β), and by promoting a robust mitochondrial network. Our data suggest a food-sensing and satiety role for mammalian Nrf proteins.https://doi.org/10.1371/journal.pgen.1009358 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Nikolaos Tataridas-Pallas Maximillian A Thompson Alexander Howard Ian Brown Marina Ezcurra Ziyun Wu Isabel Goncalves Silva Christopher D Saunter Timo Kuerten David Weinkove T Keith Blackwell Jennifer M A Tullet |
spellingShingle |
Nikolaos Tataridas-Pallas Maximillian A Thompson Alexander Howard Ian Brown Marina Ezcurra Ziyun Wu Isabel Goncalves Silva Christopher D Saunter Timo Kuerten David Weinkove T Keith Blackwell Jennifer M A Tullet Neuronal SKN-1B modulates nutritional signalling pathways and mitochondrial networks to control satiety. PLoS Genetics |
author_facet |
Nikolaos Tataridas-Pallas Maximillian A Thompson Alexander Howard Ian Brown Marina Ezcurra Ziyun Wu Isabel Goncalves Silva Christopher D Saunter Timo Kuerten David Weinkove T Keith Blackwell Jennifer M A Tullet |
author_sort |
Nikolaos Tataridas-Pallas |
title |
Neuronal SKN-1B modulates nutritional signalling pathways and mitochondrial networks to control satiety. |
title_short |
Neuronal SKN-1B modulates nutritional signalling pathways and mitochondrial networks to control satiety. |
title_full |
Neuronal SKN-1B modulates nutritional signalling pathways and mitochondrial networks to control satiety. |
title_fullStr |
Neuronal SKN-1B modulates nutritional signalling pathways and mitochondrial networks to control satiety. |
title_full_unstemmed |
Neuronal SKN-1B modulates nutritional signalling pathways and mitochondrial networks to control satiety. |
title_sort |
neuronal skn-1b modulates nutritional signalling pathways and mitochondrial networks to control satiety. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS Genetics |
issn |
1553-7390 1553-7404 |
publishDate |
2021-03-01 |
description |
The feeling of hunger or satiety results from integration of the sensory nervous system with other physiological and metabolic cues. This regulates food intake, maintains homeostasis and prevents disease. In C. elegans, chemosensory neurons sense food and relay information to the rest of the animal via hormones to control food-related behaviour and physiology. Here we identify a new component of this system, SKN-1B which acts as a central food-responsive node, ultimately controlling satiety and metabolic homeostasis. SKN-1B, an ortholog of mammalian NF-E2 related transcription factors (Nrfs), has previously been implicated with metabolism, respiration and the increased lifespan incurred by dietary restriction. Here we show that SKN-1B acts in two hypothalamus-like ASI neurons to sense food, communicate nutritional status to the organism, and control satiety and exploratory behaviours. This is achieved by SKN-1B modulating endocrine signalling pathways (IIS and TGF-β), and by promoting a robust mitochondrial network. Our data suggest a food-sensing and satiety role for mammalian Nrf proteins. |
url |
https://doi.org/10.1371/journal.pgen.1009358 |
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