Nine cases of soft tissue keratocysts arising from buccal mucosa and lateral fascial deep region: Clinicopathological and immunohistochemical study
Background: Soft tissue keratocysts (SKC) are extremely rare and show similar microscopic morphology to keratocystic odontogenic tumor. The aim was to investigate immunohistochemical (IHC) features and origin of SKCs developing in buccal mucosa and lateral facial deep region. Material and Methods: E...
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Wolters Kluwer Medknow Publications
2021-01-01
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doaj-0bba326ab88b4bec91d75ee2dfc616e22021-05-03T05:16:07ZengWolters Kluwer Medknow PublicationsIndian Journal of Pathology and Microbiology0377-49292021-01-0164233934210.4103/IJPM.IJPM_423_20Nine cases of soft tissue keratocysts arising from buccal mucosa and lateral fascial deep region: Clinicopathological and immunohistochemical studyParul KhareJingjing SunLizhen WangZhen TianChunye ZhangYuhua HuRonghui XiaJiang LiBackground: Soft tissue keratocysts (SKC) are extremely rare and show similar microscopic morphology to keratocystic odontogenic tumor. The aim was to investigate immunohistochemical (IHC) features and origin of SKCs developing in buccal mucosa and lateral facial deep region. Material and Methods: Expression of CK19, CK10/13, Ki67, Cyclin D1 and Osteopontin (OPN) of 9 SKCS were investigated using IHC. Forty different types of cysts in jaw/soft tissue were used as control. Follow-up was performed. Results: CK10/13 positivity occurred more frequently and intensely in SKC and intraosseous parakeratinized odontogenic keratocysts (COKC). However, OPN positivity was observed only in COKC. Conclusion: This is the largest case series of SKCs; along with first attempt to investigate the expression of OPN on SKC. Given the microscopic and immunohistochemical features, we prefer the view that SKC is odontogenic origin but represents the soft tissue counterpart of COKC, since their expressions of OPN were extremely different.http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2021;volume=64;issue=2;spage=339;epage=342;aulast=Khareosteopontinperipheral odontogenic keratocystsoft tissue keratocyst |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Parul Khare Jingjing Sun Lizhen Wang Zhen Tian Chunye Zhang Yuhua Hu Ronghui Xia Jiang Li |
spellingShingle |
Parul Khare Jingjing Sun Lizhen Wang Zhen Tian Chunye Zhang Yuhua Hu Ronghui Xia Jiang Li Nine cases of soft tissue keratocysts arising from buccal mucosa and lateral fascial deep region: Clinicopathological and immunohistochemical study Indian Journal of Pathology and Microbiology osteopontin peripheral odontogenic keratocyst soft tissue keratocyst |
author_facet |
Parul Khare Jingjing Sun Lizhen Wang Zhen Tian Chunye Zhang Yuhua Hu Ronghui Xia Jiang Li |
author_sort |
Parul Khare |
title |
Nine cases of soft tissue keratocysts arising from buccal mucosa and lateral fascial deep region: Clinicopathological and immunohistochemical study |
title_short |
Nine cases of soft tissue keratocysts arising from buccal mucosa and lateral fascial deep region: Clinicopathological and immunohistochemical study |
title_full |
Nine cases of soft tissue keratocysts arising from buccal mucosa and lateral fascial deep region: Clinicopathological and immunohistochemical study |
title_fullStr |
Nine cases of soft tissue keratocysts arising from buccal mucosa and lateral fascial deep region: Clinicopathological and immunohistochemical study |
title_full_unstemmed |
Nine cases of soft tissue keratocysts arising from buccal mucosa and lateral fascial deep region: Clinicopathological and immunohistochemical study |
title_sort |
nine cases of soft tissue keratocysts arising from buccal mucosa and lateral fascial deep region: clinicopathological and immunohistochemical study |
publisher |
Wolters Kluwer Medknow Publications |
series |
Indian Journal of Pathology and Microbiology |
issn |
0377-4929 |
publishDate |
2021-01-01 |
description |
Background: Soft tissue keratocysts (SKC) are extremely rare and show similar microscopic morphology to keratocystic odontogenic tumor. The aim was to investigate immunohistochemical (IHC) features and origin of SKCs developing in buccal mucosa and lateral facial deep region. Material and Methods: Expression of CK19, CK10/13, Ki67, Cyclin D1 and Osteopontin (OPN) of 9 SKCS were investigated using IHC. Forty different types of cysts in jaw/soft tissue were used as control. Follow-up was performed. Results: CK10/13 positivity occurred more frequently and intensely in SKC and intraosseous parakeratinized odontogenic keratocysts (COKC). However, OPN positivity was observed only in COKC. Conclusion: This is the largest case series of SKCs; along with first attempt to investigate the expression of OPN on SKC. Given the microscopic and immunohistochemical features, we prefer the view that SKC is odontogenic origin but represents the soft tissue counterpart of COKC, since their expressions of OPN were extremely different. |
topic |
osteopontin peripheral odontogenic keratocyst soft tissue keratocyst |
url |
http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2021;volume=64;issue=2;spage=339;epage=342;aulast=Khare |
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