Zurampic Protects Pancreatic β-Cells from High Uric Acid Induced-Damage by Inhibiting URAT1 and Inactivating the ROS/AMPK/ERK Pathways

Zurampic Protects Pancreatic β-Cells from High Uric Acid Induced-Damage by Inhibiting URAT1 and Inactivating the ROS/AMPK/ERK Pathways

Background/Aims: Zurampic is a US FDA approved drug for treatment of gout. However, the influence of Zurampic on pancreatic β-cells remains unclear. The study aimed to evaluate the effects of Zurampic on high uric acid-induced damage of pancreatic β-cells and the possible underlying mechanisms. Meth...

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Bibliographic Details
Main Authors: Ying Xin, Kun Wang, Zhaotong Jia, Tao Xu, Qiang Xu, Chao Zhang, Jia Liu, Rui Chen, Zhongcai Du, Jianjing Sun
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2018-05-01
Series:Cellular Physiology and Biochemistry
Subjects:
Zurampic
Urate transporter 1
Uric Acid
ROS/AMPK/ERK pathway
Online Access:https://www.karger.com/Article/FullText/490184

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