A Salmonella nanoparticle mimic overcomes multidrug resistance in tumours

A Salmonella nanoparticle mimic overcomes multidrug resistance in tumours

S.Typhimurium can grow selectively on tumours and decreases the cellular levels of the multidrug resistance transporter Pgp. Here, the authors reveal the SipA-dependent mechanism of Pgp down-regulation and produce a SipA-based gold nanoparticle that increases sensitivity to the anticancer drug doxor...

Full description

Bibliographic Details
Main Authors: Regino Mercado-Lubo, Yuanwei Zhang, Liang Zhao, Kyle Rossi, Xiang Wu, Yekui Zou, Antonio Castillo, Jack Leonard, Rita Bortell, Dale L. Greiner, Leonard D. Shultz, Gang Han, Beth A. McCormick
Format: Article
Language:English
Published: Nature Publishing Group 2016-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms12225
id doaj-0bc494bc80654602a8dff966f96a968c
record_format Article
spelling doaj-0bc494bc80654602a8dff966f96a968c2021-05-11T11:15:40ZengNature Publishing GroupNature Communications2041-17232016-07-017111310.1038/ncomms12225A Salmonella nanoparticle mimic overcomes multidrug resistance in tumoursRegino Mercado-Lubo0Yuanwei Zhang1Liang Zhao2Kyle Rossi3Xiang Wu4Yekui Zou5Antonio Castillo6Jack Leonard7Rita Bortell8Dale L. Greiner9Leonard D. Shultz10Gang Han11Beth A. McCormick12Department of Microbiology and Physiological SystemsDepartment of Biochemistry & Molecular PharmacologyDepartment of Biochemistry & Molecular PharmacologyDepartment of Microbiology and Physiological SystemsDepartment of Biochemistry & Molecular PharmacologyDepartment of Biochemistry & Molecular PharmacologyDepartment of Microbiology and Physiological SystemsDepartment of Microbiology and Physiological SystemsProgram in Molecular Medicine, University of Massachusetts Medical SchoolProgram in Molecular Medicine, University of Massachusetts Medical SchoolThe Jackson LaboratoryDepartment of Biochemistry & Molecular PharmacologyDepartment of Microbiology and Physiological SystemsS.Typhimurium can grow selectively on tumours and decreases the cellular levels of the multidrug resistance transporter Pgp. Here, the authors reveal the SipA-dependent mechanism of Pgp down-regulation and produce a SipA-based gold nanoparticle that increases sensitivity to the anticancer drug doxorubicin.https://doi.org/10.1038/ncomms12225
collection DOAJ
language English
format Article
sources DOAJ
author Regino Mercado-Lubo
Yuanwei Zhang
Liang Zhao
Kyle Rossi
Xiang Wu
Yekui Zou
Antonio Castillo
Jack Leonard
Rita Bortell
Dale L. Greiner
Leonard D. Shultz
Gang Han
Beth A. McCormick
spellingShingle Regino Mercado-Lubo
Yuanwei Zhang
Liang Zhao
Kyle Rossi
Xiang Wu
Yekui Zou
Antonio Castillo
Jack Leonard
Rita Bortell
Dale L. Greiner
Leonard D. Shultz
Gang Han
Beth A. McCormick
A Salmonella nanoparticle mimic overcomes multidrug resistance in tumours
Nature Communications
author_facet Regino Mercado-Lubo
Yuanwei Zhang
Liang Zhao
Kyle Rossi
Xiang Wu
Yekui Zou
Antonio Castillo
Jack Leonard
Rita Bortell
Dale L. Greiner
Leonard D. Shultz
Gang Han
Beth A. McCormick
author_sort Regino Mercado-Lubo
title A Salmonella nanoparticle mimic overcomes multidrug resistance in tumours
title_short A Salmonella nanoparticle mimic overcomes multidrug resistance in tumours
title_full A Salmonella nanoparticle mimic overcomes multidrug resistance in tumours
title_fullStr A Salmonella nanoparticle mimic overcomes multidrug resistance in tumours
title_full_unstemmed A Salmonella nanoparticle mimic overcomes multidrug resistance in tumours
title_sort salmonella nanoparticle mimic overcomes multidrug resistance in tumours
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2016-07-01
description S.Typhimurium can grow selectively on tumours and decreases the cellular levels of the multidrug resistance transporter Pgp. Here, the authors reveal the SipA-dependent mechanism of Pgp down-regulation and produce a SipA-based gold nanoparticle that increases sensitivity to the anticancer drug doxorubicin.
url https://doi.org/10.1038/ncomms12225
work_keys_str_mv AT reginomercadolubo asalmonellananoparticlemimicovercomesmultidrugresistanceintumours
AT yuanweizhang asalmonellananoparticlemimicovercomesmultidrugresistanceintumours
AT liangzhao asalmonellananoparticlemimicovercomesmultidrugresistanceintumours
AT kylerossi asalmonellananoparticlemimicovercomesmultidrugresistanceintumours
AT xiangwu asalmonellananoparticlemimicovercomesmultidrugresistanceintumours
AT yekuizou asalmonellananoparticlemimicovercomesmultidrugresistanceintumours
AT antoniocastillo asalmonellananoparticlemimicovercomesmultidrugresistanceintumours
AT jackleonard asalmonellananoparticlemimicovercomesmultidrugresistanceintumours
AT ritabortell asalmonellananoparticlemimicovercomesmultidrugresistanceintumours
AT dalelgreiner asalmonellananoparticlemimicovercomesmultidrugresistanceintumours
AT leonarddshultz asalmonellananoparticlemimicovercomesmultidrugresistanceintumours
AT ganghan asalmonellananoparticlemimicovercomesmultidrugresistanceintumours
AT bethamccormick asalmonellananoparticlemimicovercomesmultidrugresistanceintumours
AT reginomercadolubo salmonellananoparticlemimicovercomesmultidrugresistanceintumours
AT yuanweizhang salmonellananoparticlemimicovercomesmultidrugresistanceintumours
AT liangzhao salmonellananoparticlemimicovercomesmultidrugresistanceintumours
AT kylerossi salmonellananoparticlemimicovercomesmultidrugresistanceintumours
AT xiangwu salmonellananoparticlemimicovercomesmultidrugresistanceintumours
AT yekuizou salmonellananoparticlemimicovercomesmultidrugresistanceintumours
AT antoniocastillo salmonellananoparticlemimicovercomesmultidrugresistanceintumours
AT jackleonard salmonellananoparticlemimicovercomesmultidrugresistanceintumours
AT ritabortell salmonellananoparticlemimicovercomesmultidrugresistanceintumours
AT dalelgreiner salmonellananoparticlemimicovercomesmultidrugresistanceintumours
AT leonarddshultz salmonellananoparticlemimicovercomesmultidrugresistanceintumours
AT ganghan salmonellananoparticlemimicovercomesmultidrugresistanceintumours
AT bethamccormick salmonellananoparticlemimicovercomesmultidrugresistanceintumours
_version_ 1721446715352940544

Similar Items