The structurally functional characteristic of mitochondria in rat atrial cardiomyocites under the chronic opioid intoxication

• Main Author: Dunaev A.V.
• Format: Article
• Language: Russian
• Published: Ministry of Health of Ukraine. Dnipropetrovsk Medical Academy 2008-01-01
• Series: Морфологія
• Subjects: rats; myocardium; opioid intoxication; atria; cardiomyocytes; mitochondria
• Online Access: http://www.morphology.dp.ua/_pub/MORPHO-2008-02-01/08dovhoo.pdf

The purpose of the study is the morphological analysis of a condition of mitochondrial apparatus of atrial contractive cardiomyocites in rats on the chronic opioid poisoning. Modeling of the chronic opioid poisoning in rats was realized during 30 days. Morphological research comprised both light and electronic microscopy of myocardium of right and left atria, right and left auricles, and also interatrial septum. Stereological estimation of several indexes was carried out: the compactness of mitochondria, numeral compactness of mitohondria, surface area of external mitochondrial membrane, compactness of mitochondrial cristae, number of mitochondrial cristae, surface area of internal mitochondrial membrane, degree of cristae orientation, coefficient of mitochondrial sphericity, volume of mitochondrium, quantitative correlation of types of mitochondria. It was shown that the reaction of different types of mitochondria on development of chronic opioid intoxica-tion depends on the structural-metabolic type of mitochondria in atrial contractive cardiomyocites. Under the narcotic poison-ing the moderate diffuse damage of mitochondrial apparatus of contractive cardiomyocites in all atrial sites takes place that is accompanied by the reduction of 2th type mitochondria and oppressions of functional activity of high-energy mitochondria.