Nrf2-SHP Cascade-Mediated STAT3 Inactivation Contributes to AMPK-Driven Protection Against Endotoxic Inflammation

Nrf2-SHP Cascade-Mediated STAT3 Inactivation Contributes to AMPK-Driven Protection Against Endotoxic Inflammation

Signal transducer and activator of transcription 3 (STAT3) is implicated in inflammation processing, but the mechanism of its regulation mostly remains limited to Janus kinase (JAK)-mediated phosphorylation. Although AMP-activated protein kinase (AMPK)-mediated STAT3 inactivation has got documented,...

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Bibliographic Details
Main Authors: Hui Gong, Haoran Tai, Ning Huang, Peng Xiao, Chunfen Mo, Xiaobo Wang, Xiaojuan Han, Jiao Zhou, Honghan Chen, Xiaoqiang Tang, Tingting Zhao, Weitong Xu, Chuhui Gong, Gongchang Zhang, Yu Yang, Shuang Wang, Hengyi Xiao
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Immunology
Subjects:
AMPK
STAT3
Nrf2
SHP
LPS
inflammation
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.00414/full

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