Bioluminescence imaging of β cells and intrahepatic insulin gene activity under normal and pathological conditions.

In diabetes research, bioluminescence imaging (BLI) has been applied in studies of β-cell impairment, development, and islet transplantation. To develop a mouse model that enables noninvasive imaging of β cells, we generated a bacterial artificial chromosome (BAC) transgenic mouse in which a mouse 2...

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Bibliographic Details
Main Authors: Tokio Katsumata, Hisashi Oishi, Yukari Sekiguchi, Haruka Nagasaki, Dhouha Daassi, Pei-Han Tai, Masatsugu Ema, Takashi Kudo, Satoru Takahashi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3617225?pdf=render