Anchusa italica extract: phytochemical and neuroprotective evaluation on global cerebral ischemia and reperfusion
Abstract Stroke is the third leading cause of mortality and disability in industrial countries. Treatment with herbs with antioxidant properties has been reported to be an alternative to the conventional treatments. This study was conducted to investigate the effect of Anchusa italica extract on hip...
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2018-06-01
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doaj-0bdc2063f81049129357288233a369c72020-11-25T01:39:15ZengUniversidade de São PauloBrazilian Journal of Pharmaceutical Sciences2175-97902018-06-0154110.1590/s2175-97902018000117251S1984-82502018000100613Anchusa italica extract: phytochemical and neuroprotective evaluation on global cerebral ischemia and reperfusionAkram TorkiValiallah Khalaji-PirbaloutyZahra LorigooiniMahmoud Rafieian-KopaeiArezo SadeghimaneshZahra RabieiAbstract Stroke is the third leading cause of mortality and disability in industrial countries. Treatment with herbs with antioxidant properties has been reported to be an alternative to the conventional treatments. This study was conducted to investigate the effect of Anchusa italica extract on hippocampal injury induced by transient global cerebral ischemia and reperfusion in the rat. To do so, 50 rats were randomly assigned to five groups; control, sham, ischemia, and 50 or 100 mg/kg of Anchusa italica treated animals. Ischemia was induced by occlusion of carotid artery for 30 minutes. Afterward, behavioral tests and biochemical analyses were conducted. Induction of ischemia/reperfusion caused a decline in learning and passive avoidance memory in rats. Moreover, Anchusa italica caused an increase in learning and improved the passive avoidance memory. Induction of ischemia/reperfusion caused a decrease in the antioxidant capacity of the brain and serum as well as an increase in the malondialdehyde of the brain and serum. Anchusa italica led to an increase in the antioxidant capacity of the brain and serum and decrease in the malondialdehyde of the brain and serum. Overall, because of its protective effects on spatial memory, passive avoidance learning, antioxidant capacity, and lipid peroxidation during ischemia/reperfusion, Anchusa italica might be beneficial in ischemic patients.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502018000100613&lng=en&tlng=enBoraginaceae/phytochemistryBrain ischemiaSpatial memory/drug effectsMalondialdehyde/pharmacologyNeuroprotection/drug effectsLipidic peroxidation/drug effectsAntioxidant capacityPassive avoidance memory. |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Akram Torki Valiallah Khalaji-Pirbalouty Zahra Lorigooini Mahmoud Rafieian-Kopaei Arezo Sadeghimanesh Zahra Rabiei |
spellingShingle |
Akram Torki Valiallah Khalaji-Pirbalouty Zahra Lorigooini Mahmoud Rafieian-Kopaei Arezo Sadeghimanesh Zahra Rabiei Anchusa italica extract: phytochemical and neuroprotective evaluation on global cerebral ischemia and reperfusion Brazilian Journal of Pharmaceutical Sciences Boraginaceae/phytochemistry Brain ischemia Spatial memory/drug effects Malondialdehyde/pharmacology Neuroprotection/drug effects Lipidic peroxidation/drug effects Antioxidant capacity Passive avoidance memory. |
author_facet |
Akram Torki Valiallah Khalaji-Pirbalouty Zahra Lorigooini Mahmoud Rafieian-Kopaei Arezo Sadeghimanesh Zahra Rabiei |
author_sort |
Akram Torki |
title |
Anchusa italica extract: phytochemical and neuroprotective evaluation on global cerebral ischemia and reperfusion |
title_short |
Anchusa italica extract: phytochemical and neuroprotective evaluation on global cerebral ischemia and reperfusion |
title_full |
Anchusa italica extract: phytochemical and neuroprotective evaluation on global cerebral ischemia and reperfusion |
title_fullStr |
Anchusa italica extract: phytochemical and neuroprotective evaluation on global cerebral ischemia and reperfusion |
title_full_unstemmed |
Anchusa italica extract: phytochemical and neuroprotective evaluation on global cerebral ischemia and reperfusion |
title_sort |
anchusa italica extract: phytochemical and neuroprotective evaluation on global cerebral ischemia and reperfusion |
publisher |
Universidade de São Paulo |
series |
Brazilian Journal of Pharmaceutical Sciences |
issn |
2175-9790 |
publishDate |
2018-06-01 |
description |
Abstract Stroke is the third leading cause of mortality and disability in industrial countries. Treatment with herbs with antioxidant properties has been reported to be an alternative to the conventional treatments. This study was conducted to investigate the effect of Anchusa italica extract on hippocampal injury induced by transient global cerebral ischemia and reperfusion in the rat. To do so, 50 rats were randomly assigned to five groups; control, sham, ischemia, and 50 or 100 mg/kg of Anchusa italica treated animals. Ischemia was induced by occlusion of carotid artery for 30 minutes. Afterward, behavioral tests and biochemical analyses were conducted. Induction of ischemia/reperfusion caused a decline in learning and passive avoidance memory in rats. Moreover, Anchusa italica caused an increase in learning and improved the passive avoidance memory. Induction of ischemia/reperfusion caused a decrease in the antioxidant capacity of the brain and serum as well as an increase in the malondialdehyde of the brain and serum. Anchusa italica led to an increase in the antioxidant capacity of the brain and serum and decrease in the malondialdehyde of the brain and serum. Overall, because of its protective effects on spatial memory, passive avoidance learning, antioxidant capacity, and lipid peroxidation during ischemia/reperfusion, Anchusa italica might be beneficial in ischemic patients. |
topic |
Boraginaceae/phytochemistry Brain ischemia Spatial memory/drug effects Malondialdehyde/pharmacology Neuroprotection/drug effects Lipidic peroxidation/drug effects Antioxidant capacity Passive avoidance memory. |
url |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502018000100613&lng=en&tlng=en |
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