Recent Developments in the Crystallization Process: Toward the Pharmaceutical Industry
Crystallization is one of the oldest separation and purification unit operations, and has recently contributed to significant improvements in producing higher-value products with specific properties and in building efficient manufacturing processes. In this paper, we review recent developments in cr...
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doaj-0bdc825b9612448daecd91f0b4491c9c2020-11-24T23:56:38ZengElsevierEngineering2095-80992017-06-013334335310.1016/J.ENG.2017.03.022Recent Developments in the Crystallization Process: Toward the Pharmaceutical IndustryZhenguo Gao0Sohrab Rohani1Junbo Gong2Jingkang Wang3Department of Chemical and Biochemical Engineering, The University of Western Ontario, London, ON N6A 5B9, CanadaDepartment of Chemical and Biochemical Engineering, The University of Western Ontario, London, ON N6A 5B9, CanadaSchool of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, ChinaSchool of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, ChinaCrystallization is one of the oldest separation and purification unit operations, and has recently contributed to significant improvements in producing higher-value products with specific properties and in building efficient manufacturing processes. In this paper, we review recent developments in crystal engineering and crystallization process design and control in the pharmaceutical industry. We systematically summarize recent methods for understanding and developing new types of crystals such as co-crystals, polymorphs, and solvates, and include several milestones such as the launch of the first co-crystal drug, Entresto (Novartis), and the continuous manufacture of Orkambi (Vertex). Conventional batch and continuous processes, which are becoming increasingly mature, are being coupled with various control strategies and the recently developed crystallizers are thus adapting to the needs of the pharmaceutical industry. The development of crystallization process design and control has led to the appearance of several new and innovative crystallizer geometries for continuous operation and improved performance. This paper also reviews major recent progress in the area of process analytical technology.http://www.sciencedirect.com/science/article/pii/S2095809917304265CrystallizationCrystal engineeringPolymorphismCrystallization process design and controlCrystal size distribution |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Zhenguo Gao Sohrab Rohani Junbo Gong Jingkang Wang |
spellingShingle |
Zhenguo Gao Sohrab Rohani Junbo Gong Jingkang Wang Recent Developments in the Crystallization Process: Toward the Pharmaceutical Industry Engineering Crystallization Crystal engineering Polymorphism Crystallization process design and control Crystal size distribution |
author_facet |
Zhenguo Gao Sohrab Rohani Junbo Gong Jingkang Wang |
author_sort |
Zhenguo Gao |
title |
Recent Developments in the Crystallization Process: Toward the Pharmaceutical Industry |
title_short |
Recent Developments in the Crystallization Process: Toward the Pharmaceutical Industry |
title_full |
Recent Developments in the Crystallization Process: Toward the Pharmaceutical Industry |
title_fullStr |
Recent Developments in the Crystallization Process: Toward the Pharmaceutical Industry |
title_full_unstemmed |
Recent Developments in the Crystallization Process: Toward the Pharmaceutical Industry |
title_sort |
recent developments in the crystallization process: toward the pharmaceutical industry |
publisher |
Elsevier |
series |
Engineering |
issn |
2095-8099 |
publishDate |
2017-06-01 |
description |
Crystallization is one of the oldest separation and purification unit operations, and has recently contributed to significant improvements in producing higher-value products with specific properties and in building efficient manufacturing processes. In this paper, we review recent developments in crystal engineering and crystallization process design and control in the pharmaceutical industry. We systematically summarize recent methods for understanding and developing new types of crystals such as co-crystals, polymorphs, and solvates, and include several milestones such as the launch of the first co-crystal drug, Entresto (Novartis), and the continuous manufacture of Orkambi (Vertex). Conventional batch and continuous processes, which are becoming increasingly mature, are being coupled with various control strategies and the recently developed crystallizers are thus adapting to the needs of the pharmaceutical industry. The development of crystallization process design and control has led to the appearance of several new and innovative crystallizer geometries for continuous operation and improved performance. This paper also reviews major recent progress in the area of process analytical technology. |
topic |
Crystallization Crystal engineering Polymorphism Crystallization process design and control Crystal size distribution |
url |
http://www.sciencedirect.com/science/article/pii/S2095809917304265 |
work_keys_str_mv |
AT zhenguogao recentdevelopmentsinthecrystallizationprocesstowardthepharmaceuticalindustry AT sohrabrohani recentdevelopmentsinthecrystallizationprocesstowardthepharmaceuticalindustry AT junbogong recentdevelopmentsinthecrystallizationprocesstowardthepharmaceuticalindustry AT jingkangwang recentdevelopmentsinthecrystallizationprocesstowardthepharmaceuticalindustry |
_version_ |
1725457408790102016 |