The homeobox protein CEH-23 mediates prolonged longevity in response to impaired mitochondrial electron transport chain in C. elegans.

The homeobox protein CEH-23 mediates prolonged longevity in response to impaired mitochondrial electron transport chain in C. elegans.

Recent findings indicate that perturbations of the mitochondrial electron transport chain (METC) can cause extended longevity in evolutionarily diverse organisms. To uncover the molecular basis of how altered METC increases lifespan in C. elegans, we performed an RNAi screen and revealed that three...

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Bibliographic Details
Main Authors: Ludivine Walter, Aiswarya Baruah, Hsin-Wen Chang, Heather Mae Pace, Siu Sylvia Lee
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-06-01
Series:PLoS Biology
Online Access:http://europepmc.org/articles/PMC3119657?pdf=render

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