Proanthocyanidins and Flavan-3-Ols in the Prevention and Treatment of Periodontitis—Antibacterial Effects
Flavan-3-ols and their oligomeric forms called proanthocyanidins are polyphenolic compounds occurring in several foodstuffs and in many medicinal herbs. Their consumption is associated with numerous health benefits. They exhibit antioxidant, anti-inflammatory, cytoprotective, as well as antimicrobia...
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doaj-0be1d0810b9b4bea9c0ec31d7e9c1bae2021-01-08T00:01:16ZengMDPI AGNutrients2072-66432021-01-011316516510.3390/nu13010165Proanthocyanidins and Flavan-3-Ols in the Prevention and Treatment of Periodontitis—Antibacterial EffectsIzabela Nawrot-Hadzik0Adam Matkowski1Jakub Hadzik2Barbara Dobrowolska-Czopor3Cyprian Olchowy4Marzena Dominiak5Paweł Kubasiewicz-Ross6Department of Pharmaceutical Biology and Botany, Wroclaw Medical University, 50556 Wroclaw, PolandDepartment of Pharmaceutical Biology and Botany, Wroclaw Medical University, 50556 Wroclaw, PolandDepartment of Dental Surgery, Wroclaw Medical University, 50425 Wroclaw, PolandDepartment of Clinical Nursing, School of Health Sciences, Wroclaw Medical University, 50556 Wroclaw, PolandDepartment of Dental Surgery, Wroclaw Medical University, 50425 Wroclaw, PolandDepartment of Dental Surgery, Wroclaw Medical University, 50425 Wroclaw, PolandDepartment of Dental Surgery, Wroclaw Medical University, 50425 Wroclaw, PolandFlavan-3-ols and their oligomeric forms called proanthocyanidins are polyphenolic compounds occurring in several foodstuffs and in many medicinal herbs. Their consumption is associated with numerous health benefits. They exhibit antioxidant, anti-inflammatory, cytoprotective, as well as antimicrobial activity. The latter property is important in the prevention and treatment of periodontal diseases. Periodontitis is a multifactorial polymicrobial infection characterized by a destructive inflammatory process affecting the periodontium. Using non-toxic and efficient natural products such as flavanol derivatives can significantly contribute to alleviating periodontitis symptoms and preventing the disease’s progress. Therefore, a comprehensive systematic review of proanthocyanidins and flavan-3-ols in the prevention and treatment of periodontitis was performed. The present paper reviews the direct antibacterial effects of these compounds against periodontic pathogens. The immunomodulatory effects, including animal and clinical studies, are included in a separate, parallel article. There is significant evidence supporting the importance of the antibacterial action exerted by proanthocyanidins from edible fruits, tea, and medicinal herbs in the inhibition of periodontitis-causing pathogens.https://www.mdpi.com/2072-6643/13/1/165condensed tanninsproanthocyanidinsflavan-3-olsperiodontitisgingivitisgum disease |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Izabela Nawrot-Hadzik Adam Matkowski Jakub Hadzik Barbara Dobrowolska-Czopor Cyprian Olchowy Marzena Dominiak Paweł Kubasiewicz-Ross |
spellingShingle |
Izabela Nawrot-Hadzik Adam Matkowski Jakub Hadzik Barbara Dobrowolska-Czopor Cyprian Olchowy Marzena Dominiak Paweł Kubasiewicz-Ross Proanthocyanidins and Flavan-3-Ols in the Prevention and Treatment of Periodontitis—Antibacterial Effects Nutrients condensed tannins proanthocyanidins flavan-3-ols periodontitis gingivitis gum disease |
author_facet |
Izabela Nawrot-Hadzik Adam Matkowski Jakub Hadzik Barbara Dobrowolska-Czopor Cyprian Olchowy Marzena Dominiak Paweł Kubasiewicz-Ross |
author_sort |
Izabela Nawrot-Hadzik |
title |
Proanthocyanidins and Flavan-3-Ols in the Prevention and Treatment of Periodontitis—Antibacterial Effects |
title_short |
Proanthocyanidins and Flavan-3-Ols in the Prevention and Treatment of Periodontitis—Antibacterial Effects |
title_full |
Proanthocyanidins and Flavan-3-Ols in the Prevention and Treatment of Periodontitis—Antibacterial Effects |
title_fullStr |
Proanthocyanidins and Flavan-3-Ols in the Prevention and Treatment of Periodontitis—Antibacterial Effects |
title_full_unstemmed |
Proanthocyanidins and Flavan-3-Ols in the Prevention and Treatment of Periodontitis—Antibacterial Effects |
title_sort |
proanthocyanidins and flavan-3-ols in the prevention and treatment of periodontitis—antibacterial effects |
publisher |
MDPI AG |
series |
Nutrients |
issn |
2072-6643 |
publishDate |
2021-01-01 |
description |
Flavan-3-ols and their oligomeric forms called proanthocyanidins are polyphenolic compounds occurring in several foodstuffs and in many medicinal herbs. Their consumption is associated with numerous health benefits. They exhibit antioxidant, anti-inflammatory, cytoprotective, as well as antimicrobial activity. The latter property is important in the prevention and treatment of periodontal diseases. Periodontitis is a multifactorial polymicrobial infection characterized by a destructive inflammatory process affecting the periodontium. Using non-toxic and efficient natural products such as flavanol derivatives can significantly contribute to alleviating periodontitis symptoms and preventing the disease’s progress. Therefore, a comprehensive systematic review of proanthocyanidins and flavan-3-ols in the prevention and treatment of periodontitis was performed. The present paper reviews the direct antibacterial effects of these compounds against periodontic pathogens. The immunomodulatory effects, including animal and clinical studies, are included in a separate, parallel article. There is significant evidence supporting the importance of the antibacterial action exerted by proanthocyanidins from edible fruits, tea, and medicinal herbs in the inhibition of periodontitis-causing pathogens. |
topic |
condensed tannins proanthocyanidins flavan-3-ols periodontitis gingivitis gum disease |
url |
https://www.mdpi.com/2072-6643/13/1/165 |
work_keys_str_mv |
AT izabelanawrothadzik proanthocyanidinsandflavan3olsinthepreventionandtreatmentofperiodontitisantibacterialeffects AT adammatkowski proanthocyanidinsandflavan3olsinthepreventionandtreatmentofperiodontitisantibacterialeffects AT jakubhadzik proanthocyanidinsandflavan3olsinthepreventionandtreatmentofperiodontitisantibacterialeffects AT barbaradobrowolskaczopor proanthocyanidinsandflavan3olsinthepreventionandtreatmentofperiodontitisantibacterialeffects AT cyprianolchowy proanthocyanidinsandflavan3olsinthepreventionandtreatmentofperiodontitisantibacterialeffects AT marzenadominiak proanthocyanidinsandflavan3olsinthepreventionandtreatmentofperiodontitisantibacterialeffects AT pawełkubasiewiczross proanthocyanidinsandflavan3olsinthepreventionandtreatmentofperiodontitisantibacterialeffects |
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