The C. elegans neural editome reveals an ADAR target mRNA required for proper chemotaxis

The C. elegans neural editome reveals an ADAR target mRNA required for proper chemotaxis

ADAR proteins alter gene expression both by catalyzing adenosine (A) to inosine (I) RNA editing and binding to regulatory elements in target RNAs. Loss of ADARs affects neuronal function in all animals studied to date. Caenorhabditis elegans lacking ADARs exhibit reduced chemotaxis, but the targets...

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Bibliographic Details
Main Authors: Sarah N Deffit, Brian A Yee, Aidan C Manning, Suba Rajendren, Pranathi Vadlamani, Emily C Wheeler, Alain Domissy, Michael C Washburn, Gene W Yeo, Heather A Hundley
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-09-01
Series:eLife
Subjects:
RNA editing
ADAR
gene expression
RNA biology
post-transcriptional gene regulation
inosine
Online Access:https://elifesciences.org/articles/28625

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