Transcriptional Control of Regulatory T Cells in Cancer: Toward Therapeutic Targeting?
Extensive research in the past decades has highlighted the tight link between immunity and cancer, leading to the development of immunotherapies that have revolutionized cancer care. However, only a fraction of patients display durable responses to these treatments, and a deeper understanding of the...
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doaj-0c0a6219057b42f5ab639a61ccf0c9692020-11-25T04:02:10ZengMDPI AGCancers2072-66942020-10-01123194319410.3390/cancers12113194Transcriptional Control of Regulatory T Cells in Cancer: Toward Therapeutic Targeting?Pierre Stéphan0Raphaëlle Lautraite1Allison Voisin2Yenkel Grinberg-Bleyer3Cancer Research Center of Lyon, UMR INSERM 1052, CNRS 5286, Université Claude Bernard Lyon 1, Centre Léon Bérard, 69008 Lyon, FranceCancer Research Center of Lyon, UMR INSERM 1052, CNRS 5286, Université Claude Bernard Lyon 1, Centre Léon Bérard, 69008 Lyon, FranceCancer Research Center of Lyon, UMR INSERM 1052, CNRS 5286, Université Claude Bernard Lyon 1, Centre Léon Bérard, 69008 Lyon, FranceCancer Research Center of Lyon, UMR INSERM 1052, CNRS 5286, Université Claude Bernard Lyon 1, Centre Léon Bérard, 69008 Lyon, FranceExtensive research in the past decades has highlighted the tight link between immunity and cancer, leading to the development of immunotherapies that have revolutionized cancer care. However, only a fraction of patients display durable responses to these treatments, and a deeper understanding of the cellular and mechanisms orchestrating immune responses to tumors is mandatory for the discovery of novel therapeutic targets. Among the most scrutinized immune cells, Forkhead Box Protein P3 (Foxp3)<sup>+</sup> Regulatory T cells (Treg cells) are central inhibitors of protective anti-tumor immunity. These tumor-promoting functions render Treg cells attractive immunotherapy targets, and multiple strategies are being developed to inhibit their recruitment, survival, and function in the tumor microenvironment. In this context, it is critical to decipher the complex and multi-layered molecular mechanisms that shape and stabilize the Treg cell transcriptome. Here, we provide a global view of the transcription factors, and their upstream signaling pathways, involved in the programming of Treg cell homeostasis and functions in cancer. We also evaluate the feasibility and safety of novel therapeutic approaches aiming at targeting specific transcriptional regulators.https://www.mdpi.com/2072-6694/12/11/3194regulatory T cellscancertranscriptionimmunotherapy |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Pierre Stéphan Raphaëlle Lautraite Allison Voisin Yenkel Grinberg-Bleyer |
spellingShingle |
Pierre Stéphan Raphaëlle Lautraite Allison Voisin Yenkel Grinberg-Bleyer Transcriptional Control of Regulatory T Cells in Cancer: Toward Therapeutic Targeting? Cancers regulatory T cells cancer transcription immunotherapy |
author_facet |
Pierre Stéphan Raphaëlle Lautraite Allison Voisin Yenkel Grinberg-Bleyer |
author_sort |
Pierre Stéphan |
title |
Transcriptional Control of Regulatory T Cells in Cancer: Toward Therapeutic Targeting? |
title_short |
Transcriptional Control of Regulatory T Cells in Cancer: Toward Therapeutic Targeting? |
title_full |
Transcriptional Control of Regulatory T Cells in Cancer: Toward Therapeutic Targeting? |
title_fullStr |
Transcriptional Control of Regulatory T Cells in Cancer: Toward Therapeutic Targeting? |
title_full_unstemmed |
Transcriptional Control of Regulatory T Cells in Cancer: Toward Therapeutic Targeting? |
title_sort |
transcriptional control of regulatory t cells in cancer: toward therapeutic targeting? |
publisher |
MDPI AG |
series |
Cancers |
issn |
2072-6694 |
publishDate |
2020-10-01 |
description |
Extensive research in the past decades has highlighted the tight link between immunity and cancer, leading to the development of immunotherapies that have revolutionized cancer care. However, only a fraction of patients display durable responses to these treatments, and a deeper understanding of the cellular and mechanisms orchestrating immune responses to tumors is mandatory for the discovery of novel therapeutic targets. Among the most scrutinized immune cells, Forkhead Box Protein P3 (Foxp3)<sup>+</sup> Regulatory T cells (Treg cells) are central inhibitors of protective anti-tumor immunity. These tumor-promoting functions render Treg cells attractive immunotherapy targets, and multiple strategies are being developed to inhibit their recruitment, survival, and function in the tumor microenvironment. In this context, it is critical to decipher the complex and multi-layered molecular mechanisms that shape and stabilize the Treg cell transcriptome. Here, we provide a global view of the transcription factors, and their upstream signaling pathways, involved in the programming of Treg cell homeostasis and functions in cancer. We also evaluate the feasibility and safety of novel therapeutic approaches aiming at targeting specific transcriptional regulators. |
topic |
regulatory T cells cancer transcription immunotherapy |
url |
https://www.mdpi.com/2072-6694/12/11/3194 |
work_keys_str_mv |
AT pierrestephan transcriptionalcontrolofregulatorytcellsincancertowardtherapeutictargeting AT raphaellelautraite transcriptionalcontrolofregulatorytcellsincancertowardtherapeutictargeting AT allisonvoisin transcriptionalcontrolofregulatorytcellsincancertowardtherapeutictargeting AT yenkelgrinbergbleyer transcriptionalcontrolofregulatorytcellsincancertowardtherapeutictargeting |
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