Histomorphologic Spectrum in Hyaline Vascular Variant of Castleman Disease
Introduction: Castleman Disease (CD) is a rare lymphoproliferative disorder with heterogenous clinical and pathological features. It is a rare disease with mention in the rare disease data of the orphanet. It can present as unicentric or multicentric disease. Hyaline vascular variant and plasma c...
Main Authors: | , , , , , , |
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Format: | Article |
Language: | English |
Published: |
JCDR Research and Publications Private Limited
2017-08-01
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Series: | Journal of Clinical and Diagnostic Research |
Subjects: | |
Online Access: | https://jcdr.net/articles/PDF/10326/29415_CE[Ra]_F(Sh)_PF1(P_RB)_PFA(P_VSU).pdf |
Summary: | Introduction: Castleman Disease (CD) is a rare lymphoproliferative disorder with heterogenous clinical and pathological
features. It is a rare disease with mention in the rare disease
data of the orphanet. It can present as unicentric or multicentric
disease. Hyaline vascular variant and plasma cell variant are the
two pathological subtypes. Hyaline vascular variant accounts
for nearly 80% to 90% of unicentric cases. Hyaline vascular
subtype variant has follicular and stroma rich subtype.
Aim: To study the histomorphologic spectrum of hyaline
vascular variant of CD.
Materials and Methods: Retrospective cross-sectional,
observational study was undertaken from the archival data
between January 2009 and April 2015. Only ten cases of hyaline
vascular CD were identified after studying the histomorphological
characteristics. Both follicular and interfollicular changes were
studied in detail.
Results: The age of presentation ranged from 17 years to 59
years. Seven out of 10 cases were female. Site of presentation
included cervical, inguinal, retroperitoneal, intra-abdominal and
axillary. Six cases showed predominant follicular change. Two
cases were sclerotic subtype. Two cases showed both follicular
and interfollicular changes in equal proportion.
Distribution of follicles throughout the lymphnode was seen
in eight cases. Uniform sized follicles seen in seven out of ten
cases. Small germinal centre with lymphocyte depletion was
one of the uniform features seen in all 10 cases. Numerous
high endothelial vessels were seen in nine cases. Twinning of
germinal centre was seen in two cases. All ten cases showed
concentric rings of small lymphocytes. Lollipop pattern was
relatively rare feature seen in only two cases.
Conclusion: Hyaline vascular variant of CD has considerable
morphologic variation with few consistent features seen in most
of the cases. |
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ISSN: | 2249-782X 0973-709X |