Effect of mild hypothermia combined with VitC and EPO therapy on target organ damage in children with neonatal asphyxia
Objective: To study the effect of mild hypothermia combined with vitamin C (VitC) and erythropoietin (EPO) therapy on target organ damage in children with neonatal asphyxia. Methods: Children with neonatal asphyxia who were treated in Taihe County People’s Hospital between April 2014 and February...
Main Author: | |
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Format: | Article |
Language: | English |
Published: |
Editorial Board of Journal of Hainan Medical University
2017-10-01
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Series: | Journal of Hainan Medical University |
Subjects: | |
Online Access: | http://www.hnykdxxb.com/PDF/201719/29.pdf |
Summary: | Objective: To study the effect of mild hypothermia combined with vitamin C (VitC) and
erythropoietin (EPO) therapy on target organ damage in children with neonatal asphyxia.
Methods: Children with neonatal asphyxia who were treated in Taihe County People’s
Hospital between April 2014 and February 2017 were selected and randomly divided into two
groups, mild hypothermia group received mild hypothermia combined VitC and EPO therapy,
and control group received VitC and EPO therapy. Serum levels of of target organ damage
markers, oxidative stress indexes and apoptosis indexes were measured before treatment as
well as 3 d and 7 d after treatment. Results: 3 d and 7 d after treatment, serum NSE, H-FABP,
cTnI, CysC, MDA, Caspase-3, PDCD5, sFas and sFasL levels of both groups of children were
significantly lower than those before treatment while TAS, SOD, GSH and Bcl-2 levels were
significantly higher than those before treatment, and serum NSE, H-FABP, cTnI, CysC, MDA,
Caspase-3, PDCD5, sFas and sFasL levels of mild hypothermia group were significantly lower
than those of control group while TAS, SOD, GSH and Bcl-2 levels were significantly higher
than those of control group. Conclusion: Mild hypothermia combined with VitC and EPO
therapy can reduce the target organ damage of children with neonatal asphyxia by inhibiting
oxidative stress and apoptosis. |
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ISSN: | 1007-1237 1007-1237 |