Two to Tango: Dialogue between Adaptive and Innate Immunity in Type 1 Diabetes

Two to Tango: Dialogue between Adaptive and Innate Immunity in Type 1 Diabetes

Type 1 diabetes mellitus (T1DM) is a long-term and chronic autoimmune disorder, in which the immune system attacks the pancreatic β-cells. Both adaptive and innate immune systems are involved in T1DM development. Both B-cells and T-cells, including CD4+ and CD8+ T-cells, as well as other T-cell subs...

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Main Authors: Lin Sun, Shugang Xi, Guangyu He, Zhuo Li, Xiaokun Gang, Chenglin Sun, Weiying Guo, Guixia Wang
Format: Article
Language:English
Published: Hindawi Limited 2020-01-01
Series:Journal of Diabetes Research
Online Access:http://dx.doi.org/10.1155/2020/4106518
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spelling doaj-0c1e32dc07d44b2281c57bc7c99814eb2020-11-25T03:18:59ZengHindawi LimitedJournal of Diabetes Research2314-67452314-67532020-01-01202010.1155/2020/41065184106518Two to Tango: Dialogue between Adaptive and Innate Immunity in Type 1 DiabetesLin Sun0Shugang Xi1Guangyu He2Zhuo Li3Xiaokun Gang4Chenglin Sun5Weiying Guo6Guixia Wang7Department of Endocrinology and Metabolism, The First Hospital of Jilin University, Changchun, 130021 Jilin, ChinaDepartment of Endocrinology and Metabolism, The First Hospital of Jilin University, Changchun, 130021 Jilin, ChinaDepartment of Endocrinology and Metabolism, The First Hospital of Jilin University, Changchun, 130021 Jilin, ChinaDepartment of Endocrinology and Metabolism, The First Hospital of Jilin University, Changchun, 130021 Jilin, ChinaDepartment of Endocrinology and Metabolism, The First Hospital of Jilin University, Changchun, 130021 Jilin, ChinaDepartment of Endocrinology and Metabolism, The First Hospital of Jilin University, Changchun, 130021 Jilin, ChinaDepartment of Endocrinology and Metabolism, The First Hospital of Jilin University, Changchun, 130021 Jilin, ChinaDepartment of Endocrinology and Metabolism, The First Hospital of Jilin University, Changchun, 130021 Jilin, ChinaType 1 diabetes mellitus (T1DM) is a long-term and chronic autoimmune disorder, in which the immune system attacks the pancreatic β-cells. Both adaptive and innate immune systems are involved in T1DM development. Both B-cells and T-cells, including CD4+ and CD8+ T-cells, as well as other T-cell subsets, could affect onset of autoimmunity. Furthermore, cells involved in innate immunity, including the macrophages, dendritic cells, and natural killer (NK) cells, could also accelerate or decelerate T1DM development. In this review, the crosstalk and function of immune cells in the pathogenesis of T1DM, as well as the corresponding therapeutic interventions, are discussed.http://dx.doi.org/10.1155/2020/4106518
collection DOAJ
language English
format Article
sources DOAJ
author Lin Sun
Shugang Xi
Guangyu He
Zhuo Li
Xiaokun Gang
Chenglin Sun
Weiying Guo
Guixia Wang
spellingShingle Lin Sun
Shugang Xi
Guangyu He
Zhuo Li
Xiaokun Gang
Chenglin Sun
Weiying Guo
Guixia Wang
Two to Tango: Dialogue between Adaptive and Innate Immunity in Type 1 Diabetes
Journal of Diabetes Research
author_facet Lin Sun
Shugang Xi
Guangyu He
Zhuo Li
Xiaokun Gang
Chenglin Sun
Weiying Guo
Guixia Wang
author_sort Lin Sun
title Two to Tango: Dialogue between Adaptive and Innate Immunity in Type 1 Diabetes
title_short Two to Tango: Dialogue between Adaptive and Innate Immunity in Type 1 Diabetes
title_full Two to Tango: Dialogue between Adaptive and Innate Immunity in Type 1 Diabetes
title_fullStr Two to Tango: Dialogue between Adaptive and Innate Immunity in Type 1 Diabetes
title_full_unstemmed Two to Tango: Dialogue between Adaptive and Innate Immunity in Type 1 Diabetes
title_sort two to tango: dialogue between adaptive and innate immunity in type 1 diabetes
publisher Hindawi Limited
series Journal of Diabetes Research
issn 2314-6745
2314-6753
publishDate 2020-01-01
description Type 1 diabetes mellitus (T1DM) is a long-term and chronic autoimmune disorder, in which the immune system attacks the pancreatic β-cells. Both adaptive and innate immune systems are involved in T1DM development. Both B-cells and T-cells, including CD4+ and CD8+ T-cells, as well as other T-cell subsets, could affect onset of autoimmunity. Furthermore, cells involved in innate immunity, including the macrophages, dendritic cells, and natural killer (NK) cells, could also accelerate or decelerate T1DM development. In this review, the crosstalk and function of immune cells in the pathogenesis of T1DM, as well as the corresponding therapeutic interventions, are discussed.
url http://dx.doi.org/10.1155/2020/4106518
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