Collagen vitrigel promotes hepatocytic differentiation of induced pluripotent stem cells into functional hepatocyte-like cells

Collagen vitrigel promotes hepatocytic differentiation of induced pluripotent stem cells into functional hepatocyte-like cells

Differentiation of stem cells to hepatocytes provides an unlimited supply of human hepatocytes and therefore has been vigorously studied. However, to date, the stem cell-derived hepatocytes were suggested to be of immature features. To obtain matured hepatocytes from stem cells, we tested the effect...

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Bibliographic Details
Main Authors: Shun Nakai, Ima Shibata, Takahiro Shitamichi, Hiroyuki Yamaguchi, Nobuyuki Takagi, Tomoaki Inoue, Toshito Nakagawa, Jumpei Kiyokawa, Satoshi Wakabayashi, Tomoya Miyoshi, Eriko Higashi, Seiichi Ishida, Nobuaki Shiraki, Shoen Kume
Format: Article
Language:English
Published: The Company of Biologists 2019-07-01
Series:Biology Open
Subjects:
Hepatocytic differentiation
In vitro differentiation
Induced pluripotent stem cells
Online Access:http://bio.biologists.org/content/8/7/bio042192

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