Acetylcholine Attenuates Hypoxia/ Reoxygenation-Induced Mitochondrial and Cytosolic ROS Formation in H9c2 Cells via M2 Acetylcholine Receptor

Acetylcholine Attenuates Hypoxia/ Reoxygenation-Induced Mitochondrial and Cytosolic ROS Formation in H9c2 Cells via M2 Acetylcholine Receptor

Background: The anti-infammatory and cardioprotective effect of acetylcholine (ACh) has been reported; nevertheless, whether and how ACh exhibits an antioxidant property against ischemia/reperfusion (I/R)-induced oxidative stress remains obscure. Methods: In the present study, H9c2 rat cardiomyocyte...

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Bibliographic Details
Main Authors: Yi Miao, Jun Zhou, Mei Zhao, Jinjun Liu, Lei Sun, Xiaojiang Yu, Xi He, Xiaoyue Pan, Weijin Zang
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2013-02-01
Series:Cellular Physiology and Biochemistry
Subjects:
Acetylcholine
Hypoxia/reoxygenation
Reactive oxygen species
Electronic transport chain
NADPH oxidase
Xanthine oxidase
M2 acetylcholine receptor
Online Access:http://www.karger.com/Article/FullText/343360

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http://www.karger.com/Article/FullText/343360

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