Transcription factor Emx2 controls stereociliary bundle orientation of sensory hair cells
The asymmetric location of stereociliary bundle (hair bundle) on the apical surface of mechanosensory hair cells (HCs) dictates the direction in which a given HC can respond to cues such as sound, head movements, and water pressure. Notably, vestibular sensory organs of the inner ear, the maculae, e...
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doaj-0c41274673e44fbf8cc0e9b2ce0845ad2021-05-05T13:19:14ZengeLife Sciences Publications LtdeLife2050-084X2017-03-01610.7554/eLife.23661Transcription factor Emx2 controls stereociliary bundle orientation of sensory hair cellsTao Jiang0Katie Kindt1https://orcid.org/0000-0002-1065-8215Doris K Wu2https://orcid.org/0000-0002-1400-3558Program in Neuroscience and Cognitive Science, University of Maryland, College Park, United States; Laboratory of Molecular Biology, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, United StatesSection on Sensory Cell Development, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, United StatesLaboratory of Molecular Biology, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, United StatesThe asymmetric location of stereociliary bundle (hair bundle) on the apical surface of mechanosensory hair cells (HCs) dictates the direction in which a given HC can respond to cues such as sound, head movements, and water pressure. Notably, vestibular sensory organs of the inner ear, the maculae, exhibit a line of polarity reversal (LPR) across which, hair bundles are polarized in a mirror-image pattern. Similarly, HCs in neuromasts of the zebrafish lateral line system are generated as pairs, and two sibling HCs develop opposite hair bundle orientations. Within these sensory organs, expression of the transcription factor Emx2 is restricted to only one side of the LPR in the maculae or one of the two sibling HCs in neuromasts. Emx2 mediates hair bundle polarity reversal in these restricted subsets of HCs and generates the mirror-image pattern of the sensory organs. Downstream effectors of Emx2 control bundle polarity cell-autonomously via heterotrimeric G proteins.https://elifesciences.org/articles/23661inner earneuromastplanar cell polarityutriclesacculeline of polarity reversal |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Tao Jiang Katie Kindt Doris K Wu |
spellingShingle |
Tao Jiang Katie Kindt Doris K Wu Transcription factor Emx2 controls stereociliary bundle orientation of sensory hair cells eLife inner ear neuromast planar cell polarity utricle saccule line of polarity reversal |
author_facet |
Tao Jiang Katie Kindt Doris K Wu |
author_sort |
Tao Jiang |
title |
Transcription factor Emx2 controls stereociliary bundle orientation of sensory hair cells |
title_short |
Transcription factor Emx2 controls stereociliary bundle orientation of sensory hair cells |
title_full |
Transcription factor Emx2 controls stereociliary bundle orientation of sensory hair cells |
title_fullStr |
Transcription factor Emx2 controls stereociliary bundle orientation of sensory hair cells |
title_full_unstemmed |
Transcription factor Emx2 controls stereociliary bundle orientation of sensory hair cells |
title_sort |
transcription factor emx2 controls stereociliary bundle orientation of sensory hair cells |
publisher |
eLife Sciences Publications Ltd |
series |
eLife |
issn |
2050-084X |
publishDate |
2017-03-01 |
description |
The asymmetric location of stereociliary bundle (hair bundle) on the apical surface of mechanosensory hair cells (HCs) dictates the direction in which a given HC can respond to cues such as sound, head movements, and water pressure. Notably, vestibular sensory organs of the inner ear, the maculae, exhibit a line of polarity reversal (LPR) across which, hair bundles are polarized in a mirror-image pattern. Similarly, HCs in neuromasts of the zebrafish lateral line system are generated as pairs, and two sibling HCs develop opposite hair bundle orientations. Within these sensory organs, expression of the transcription factor Emx2 is restricted to only one side of the LPR in the maculae or one of the two sibling HCs in neuromasts. Emx2 mediates hair bundle polarity reversal in these restricted subsets of HCs and generates the mirror-image pattern of the sensory organs. Downstream effectors of Emx2 control bundle polarity cell-autonomously via heterotrimeric G proteins. |
topic |
inner ear neuromast planar cell polarity utricle saccule line of polarity reversal |
url |
https://elifesciences.org/articles/23661 |
work_keys_str_mv |
AT taojiang transcriptionfactoremx2controlsstereociliarybundleorientationofsensoryhaircells AT katiekindt transcriptionfactoremx2controlsstereociliarybundleorientationofsensoryhaircells AT doriskwu transcriptionfactoremx2controlsstereociliarybundleorientationofsensoryhaircells |
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1721461959523565568 |