Transcription factor Emx2 controls stereociliary bundle orientation of sensory hair cells

The asymmetric location of stereociliary bundle (hair bundle) on the apical surface of mechanosensory hair cells (HCs) dictates the direction in which a given HC can respond to cues such as sound, head movements, and water pressure. Notably, vestibular sensory organs of the inner ear, the maculae, e...

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Main Authors: Tao Jiang, Katie Kindt, Doris K Wu
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-03-01
Series:eLife
Subjects:
Online Access:https://elifesciences.org/articles/23661
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spelling doaj-0c41274673e44fbf8cc0e9b2ce0845ad2021-05-05T13:19:14ZengeLife Sciences Publications LtdeLife2050-084X2017-03-01610.7554/eLife.23661Transcription factor Emx2 controls stereociliary bundle orientation of sensory hair cellsTao Jiang0Katie Kindt1https://orcid.org/0000-0002-1065-8215Doris K Wu2https://orcid.org/0000-0002-1400-3558Program in Neuroscience and Cognitive Science, University of Maryland, College Park, United States; Laboratory of Molecular Biology, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, United StatesSection on Sensory Cell Development, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, United StatesLaboratory of Molecular Biology, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, United StatesThe asymmetric location of stereociliary bundle (hair bundle) on the apical surface of mechanosensory hair cells (HCs) dictates the direction in which a given HC can respond to cues such as sound, head movements, and water pressure. Notably, vestibular sensory organs of the inner ear, the maculae, exhibit a line of polarity reversal (LPR) across which, hair bundles are polarized in a mirror-image pattern. Similarly, HCs in neuromasts of the zebrafish lateral line system are generated as pairs, and two sibling HCs develop opposite hair bundle orientations. Within these sensory organs, expression of the transcription factor Emx2 is restricted to only one side of the LPR in the maculae or one of the two sibling HCs in neuromasts. Emx2 mediates hair bundle polarity reversal in these restricted subsets of HCs and generates the mirror-image pattern of the sensory organs. Downstream effectors of Emx2 control bundle polarity cell-autonomously via heterotrimeric G proteins.https://elifesciences.org/articles/23661inner earneuromastplanar cell polarityutriclesacculeline of polarity reversal
collection DOAJ
language English
format Article
sources DOAJ
author Tao Jiang
Katie Kindt
Doris K Wu
spellingShingle Tao Jiang
Katie Kindt
Doris K Wu
Transcription factor Emx2 controls stereociliary bundle orientation of sensory hair cells
eLife
inner ear
neuromast
planar cell polarity
utricle
saccule
line of polarity reversal
author_facet Tao Jiang
Katie Kindt
Doris K Wu
author_sort Tao Jiang
title Transcription factor Emx2 controls stereociliary bundle orientation of sensory hair cells
title_short Transcription factor Emx2 controls stereociliary bundle orientation of sensory hair cells
title_full Transcription factor Emx2 controls stereociliary bundle orientation of sensory hair cells
title_fullStr Transcription factor Emx2 controls stereociliary bundle orientation of sensory hair cells
title_full_unstemmed Transcription factor Emx2 controls stereociliary bundle orientation of sensory hair cells
title_sort transcription factor emx2 controls stereociliary bundle orientation of sensory hair cells
publisher eLife Sciences Publications Ltd
series eLife
issn 2050-084X
publishDate 2017-03-01
description The asymmetric location of stereociliary bundle (hair bundle) on the apical surface of mechanosensory hair cells (HCs) dictates the direction in which a given HC can respond to cues such as sound, head movements, and water pressure. Notably, vestibular sensory organs of the inner ear, the maculae, exhibit a line of polarity reversal (LPR) across which, hair bundles are polarized in a mirror-image pattern. Similarly, HCs in neuromasts of the zebrafish lateral line system are generated as pairs, and two sibling HCs develop opposite hair bundle orientations. Within these sensory organs, expression of the transcription factor Emx2 is restricted to only one side of the LPR in the maculae or one of the two sibling HCs in neuromasts. Emx2 mediates hair bundle polarity reversal in these restricted subsets of HCs and generates the mirror-image pattern of the sensory organs. Downstream effectors of Emx2 control bundle polarity cell-autonomously via heterotrimeric G proteins.
topic inner ear
neuromast
planar cell polarity
utricle
saccule
line of polarity reversal
url https://elifesciences.org/articles/23661
work_keys_str_mv AT taojiang transcriptionfactoremx2controlsstereociliarybundleorientationofsensoryhaircells
AT katiekindt transcriptionfactoremx2controlsstereociliarybundleorientationofsensoryhaircells
AT doriskwu transcriptionfactoremx2controlsstereociliarybundleorientationofsensoryhaircells
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