BDNF impact on synaptic dynamics: extra or intracellular long-term release differently regulates cultured hippocampal synapses

BDNF impact on synaptic dynamics: extra or intracellular long-term release differently regulates cultured hippocampal synapses

Abstract Brain Derived Neurotrophic Factor (BDNF) signalling contributes to the formation, maturation and plasticity of Central Nervous System (CNS) synapses. Acute exposure of cultured brain circuits to BDNF leads to up-regulation of glutamatergic neuro-transmission, by the accurate tuning of pre a...

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Bibliographic Details
Main Authors: Rossana Rauti, Giada Cellot, Paola D’Andrea, Andrea Colliva, Denis Scaini, Enrico Tongiorgi, Laura Ballerini
Format: Article
Language:English
Published: BMC 2020-03-01
Series:Molecular Brain
Subjects:
Neurotrophin
Hippocampal network
Patch-clamp
Synaptic activity
Miniature synaptic current
Online Access:http://link.springer.com/article/10.1186/s13041-020-00582-9

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