T Cells in Autoimmunity-Associated Cardiovascular Diseases
T cells are indisputably critical mediators of atherosclerotic cardiovascular disease (CVD), where they secrete pro-inflammatory cytokines that promote vascular pathology. Equally well-established is the fact that autoimmune diseases, which are mediated by autoreactive T cells, substantially increas...
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doaj-0c5ee8037c254883abf62aa771b333252020-11-25T03:54:40ZengFrontiers Media S.A.Frontiers in Immunology1664-32242020-10-011110.3389/fimmu.2020.588776588776T Cells in Autoimmunity-Associated Cardiovascular DiseasesDaniella Muallem Schwartz0Aarohan M. Burma1Moses M. Kitakule2Yiming Luo3Nehal N. Mehta4Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United StatesLaboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United StatesLaboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United StatesRheumatology Fellowship Program, National Institute of Arthritis, Musculoskeletal, and Skin Diseases, National Institutes of Health, Bethesda, MD, United StatesSection of Inflammation and Cardiometabolic Diseases, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, United StatesT cells are indisputably critical mediators of atherosclerotic cardiovascular disease (CVD), where they secrete pro-inflammatory cytokines that promote vascular pathology. Equally well-established is the fact that autoimmune diseases, which are mediated by autoreactive T cells, substantially increase the risk of developing CVD. Indeed, as immunomodulatory treatments have become more effective at treating end-organ pathology, CVD has become a leading cause of death in patients with autoimmune diseases. Despite this, investigators have only recently begun to probe the mechanisms by which autoreactive T cells promote CVD in the context of autoimmune diseases. T cells are best-studied in the pathogenesis of systemic vasculitides, where they react to self-antigen in the vessel wall. However, newer studies indicate that T cells also contribute to the increased CVD risk associated with lupus and rheumatoid arthritis. Given the central role of T-cell-derived cytokines in the pathogenesis of psoriasis, the role of these factors in psoriatic CVD is also under investigation. In the future, T cells are likely to represent major targets for the prevention and treatment of CVD in patients with autoimmune diseases.https://www.frontiersin.org/article/10.3389/fimmu.2020.588776/fullT cellsautoimmunitycardiovascularsystemic lupus erythematosus (SLE)rheumatoid arthritis (RA)psoriasis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Daniella Muallem Schwartz Aarohan M. Burma Moses M. Kitakule Yiming Luo Nehal N. Mehta |
spellingShingle |
Daniella Muallem Schwartz Aarohan M. Burma Moses M. Kitakule Yiming Luo Nehal N. Mehta T Cells in Autoimmunity-Associated Cardiovascular Diseases Frontiers in Immunology T cells autoimmunity cardiovascular systemic lupus erythematosus (SLE) rheumatoid arthritis (RA) psoriasis |
author_facet |
Daniella Muallem Schwartz Aarohan M. Burma Moses M. Kitakule Yiming Luo Nehal N. Mehta |
author_sort |
Daniella Muallem Schwartz |
title |
T Cells in Autoimmunity-Associated Cardiovascular Diseases |
title_short |
T Cells in Autoimmunity-Associated Cardiovascular Diseases |
title_full |
T Cells in Autoimmunity-Associated Cardiovascular Diseases |
title_fullStr |
T Cells in Autoimmunity-Associated Cardiovascular Diseases |
title_full_unstemmed |
T Cells in Autoimmunity-Associated Cardiovascular Diseases |
title_sort |
t cells in autoimmunity-associated cardiovascular diseases |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Immunology |
issn |
1664-3224 |
publishDate |
2020-10-01 |
description |
T cells are indisputably critical mediators of atherosclerotic cardiovascular disease (CVD), where they secrete pro-inflammatory cytokines that promote vascular pathology. Equally well-established is the fact that autoimmune diseases, which are mediated by autoreactive T cells, substantially increase the risk of developing CVD. Indeed, as immunomodulatory treatments have become more effective at treating end-organ pathology, CVD has become a leading cause of death in patients with autoimmune diseases. Despite this, investigators have only recently begun to probe the mechanisms by which autoreactive T cells promote CVD in the context of autoimmune diseases. T cells are best-studied in the pathogenesis of systemic vasculitides, where they react to self-antigen in the vessel wall. However, newer studies indicate that T cells also contribute to the increased CVD risk associated with lupus and rheumatoid arthritis. Given the central role of T-cell-derived cytokines in the pathogenesis of psoriasis, the role of these factors in psoriatic CVD is also under investigation. In the future, T cells are likely to represent major targets for the prevention and treatment of CVD in patients with autoimmune diseases. |
topic |
T cells autoimmunity cardiovascular systemic lupus erythematosus (SLE) rheumatoid arthritis (RA) psoriasis |
url |
https://www.frontiersin.org/article/10.3389/fimmu.2020.588776/full |
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