High-risk human papillomavirus, other than type 16/18, in predominantly older Taiwanese women with high-grade cervical preinvasive lesions
Objective: To investigate the various genotypes of human papillomavirus (HPV) in Taiwanese women patients with abnormal cervical cytology and analyze the associations between HPV types, cervical preinvasive lesions, and the medical characteristics of these patients. Materials and Methods: We perform...
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doaj-0c6c75db07654c71bca22a90e392582d2020-11-24T23:53:28ZengElsevierTaiwanese Journal of Obstetrics & Gynecology1028-45592013-06-0152222222610.1016/j.tjog.2013.04.012High-risk human papillomavirus, other than type 16/18, in predominantly older Taiwanese women with high-grade cervical preinvasive lesionsYing-Cheng Chiang0Wen-Fang Cheng1Yu-Li Chen2Ming-Cheng Chang3Chang-Yao Hsieh4Ming-Chieh Lin5Chi-An Chen6Department of Obstetrics and Gynecology, College of Medicine, National Taiwan University, Taipei, TaiwanDepartment of Obstetrics and Gynecology, College of Medicine, National Taiwan University, Taipei, TaiwanGynecologic Cancer Center, Department of Obstetrics and Gynecology, Cathay General Hospital, Taipei, TaiwanDepartment of Obstetrics and Gynecology, College of Medicine, National Taiwan University, Taipei, TaiwanDepartment of Obstetrics and Gynecology, College of Medicine, National Taiwan University, Taipei, TaiwanDepartment of Pathology, College of Medicine, National Taiwan University, Taipei, TaiwanDepartment of Obstetrics and Gynecology, College of Medicine, National Taiwan University, Taipei, TaiwanObjective: To investigate the various genotypes of human papillomavirus (HPV) in Taiwanese women patients with abnormal cervical cytology and analyze the associations between HPV types, cervical preinvasive lesions, and the medical characteristics of these patients. Materials and Methods: We performed HPV genotyping GeneChip procedures and colposcopies for 784 women with abnormal Papanicolaou smears. The characteristics of the patients and the status of the HPV infection were correlated. Results: A total of 706 (90.1%) of the 784 women were positive for HPV infection, including 641 patients with high-risk HPV (HR-HPV). Among the patients with high-grade squamous intraepithelial lesions (HSILs), the average age of the 273 patients with other HR-HPV types (48.6 ± 13.8 years) was significantly older than the 222 patients infected with HPV 16/18 (39.8 ± 11.8 years) (p < 0.001). The proportion of patients with HSILs who were older than 40 years and infected with other HR-HPV types (76.6%) was also significantly higher than those with HPV 16/18 (20.3%) (p < 0.001). Conclusion: Women older than 40 years and having abnormal Pap smears and HR-HPV infections other than type 16/18 should be managed carefully because of the risk for HSILs.http://www.sciencedirect.com/science/article/pii/S1028455913000685high-grade squamous intraepithelial lesionhuman papillomavirusTaiwanese women |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ying-Cheng Chiang Wen-Fang Cheng Yu-Li Chen Ming-Cheng Chang Chang-Yao Hsieh Ming-Chieh Lin Chi-An Chen |
spellingShingle |
Ying-Cheng Chiang Wen-Fang Cheng Yu-Li Chen Ming-Cheng Chang Chang-Yao Hsieh Ming-Chieh Lin Chi-An Chen High-risk human papillomavirus, other than type 16/18, in predominantly older Taiwanese women with high-grade cervical preinvasive lesions Taiwanese Journal of Obstetrics & Gynecology high-grade squamous intraepithelial lesion human papillomavirus Taiwanese women |
author_facet |
Ying-Cheng Chiang Wen-Fang Cheng Yu-Li Chen Ming-Cheng Chang Chang-Yao Hsieh Ming-Chieh Lin Chi-An Chen |
author_sort |
Ying-Cheng Chiang |
title |
High-risk human papillomavirus, other than type 16/18, in predominantly older Taiwanese women with high-grade cervical preinvasive lesions |
title_short |
High-risk human papillomavirus, other than type 16/18, in predominantly older Taiwanese women with high-grade cervical preinvasive lesions |
title_full |
High-risk human papillomavirus, other than type 16/18, in predominantly older Taiwanese women with high-grade cervical preinvasive lesions |
title_fullStr |
High-risk human papillomavirus, other than type 16/18, in predominantly older Taiwanese women with high-grade cervical preinvasive lesions |
title_full_unstemmed |
High-risk human papillomavirus, other than type 16/18, in predominantly older Taiwanese women with high-grade cervical preinvasive lesions |
title_sort |
high-risk human papillomavirus, other than type 16/18, in predominantly older taiwanese women with high-grade cervical preinvasive lesions |
publisher |
Elsevier |
series |
Taiwanese Journal of Obstetrics & Gynecology |
issn |
1028-4559 |
publishDate |
2013-06-01 |
description |
Objective: To investigate the various genotypes of human papillomavirus (HPV) in Taiwanese women patients with abnormal cervical cytology and analyze the associations between HPV types, cervical preinvasive lesions, and the medical characteristics of these patients.
Materials and Methods: We performed HPV genotyping GeneChip procedures and colposcopies for 784 women with abnormal Papanicolaou smears. The characteristics of the patients and the status of the HPV infection were correlated.
Results: A total of 706 (90.1%) of the 784 women were positive for HPV infection, including 641 patients with high-risk HPV (HR-HPV). Among the patients with high-grade squamous intraepithelial lesions (HSILs), the average age of the 273 patients with other HR-HPV types (48.6 ± 13.8 years) was significantly older than the 222 patients infected with HPV 16/18 (39.8 ± 11.8 years) (p < 0.001). The proportion of patients with HSILs who were older than 40 years and infected with other HR-HPV types (76.6%) was also significantly higher than those with HPV 16/18 (20.3%) (p < 0.001).
Conclusion: Women older than 40 years and having abnormal Pap smears and HR-HPV infections other than type 16/18 should be managed carefully because of the risk for HSILs. |
topic |
high-grade squamous intraepithelial lesion human papillomavirus Taiwanese women |
url |
http://www.sciencedirect.com/science/article/pii/S1028455913000685 |
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