Molecular Epidemiology of Eastern Equine Encephalitis Virus, New York
Perpetuation, overwintering, and extinction of eastern equine encephalitis virus (EEEV) in northern foci are poorly understood. We therefore sought to describe the molecular epidemiology of EEEV in New York State during current and past epizootics. To determine whether EEEV overwinters, is periodica...
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doaj-0c7496cbe6524b3d92ce69d80c776a012020-11-25T01:40:02ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592008-03-0114345446010.3201/eid1403.070816Molecular Epidemiology of Eastern Equine Encephalitis Virus, New YorkDavid S. YoungLaura D. KramerJoseph G. MaffeiRobert J. DusekP. Bryon BackensonChristopher N. MoresKristen A. BernardGregory D. EbelPerpetuation, overwintering, and extinction of eastern equine encephalitis virus (EEEV) in northern foci are poorly understood. We therefore sought to describe the molecular epidemiology of EEEV in New York State during current and past epizootics. To determine whether EEEV overwinters, is periodically reintroduced, or both, we sequenced the E2 and partial NSP3 coding regions of 42 EEEV isolates from New York State and the Eastern Seaboard of the United States. Our phylogenetic analyses indicated that derived subclades tended to contain southern strains that had been isolated before genetically similar northern strains, suggesting southern to northern migration of EEEV along the Eastern Seaboard. Strong clustering among strains isolated during epizootics in New York from 2003–2005, as well as from 1974–1975, demonstrates that EEEV has overwintered in this focus. This study provides molecular evidence for the introduction of southern EEEV strains to New York, followed by local amplification, perpetuation, and overwintering.https://wwwnc.cdc.gov/eid/article/14/3/07-0816_articleEastern equine encephalitis virus, Alphavirus, Togaviridae, Arboviruses, epidemiology, molecularresearchNew YorkUnited States |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
David S. Young Laura D. Kramer Joseph G. Maffei Robert J. Dusek P. Bryon Backenson Christopher N. Mores Kristen A. Bernard Gregory D. Ebel |
spellingShingle |
David S. Young Laura D. Kramer Joseph G. Maffei Robert J. Dusek P. Bryon Backenson Christopher N. Mores Kristen A. Bernard Gregory D. Ebel Molecular Epidemiology of Eastern Equine Encephalitis Virus, New York Emerging Infectious Diseases Eastern equine encephalitis virus, Alphavirus, Togaviridae, Arboviruses, epidemiology, molecular research New York United States |
author_facet |
David S. Young Laura D. Kramer Joseph G. Maffei Robert J. Dusek P. Bryon Backenson Christopher N. Mores Kristen A. Bernard Gregory D. Ebel |
author_sort |
David S. Young |
title |
Molecular Epidemiology of Eastern Equine Encephalitis Virus, New York |
title_short |
Molecular Epidemiology of Eastern Equine Encephalitis Virus, New York |
title_full |
Molecular Epidemiology of Eastern Equine Encephalitis Virus, New York |
title_fullStr |
Molecular Epidemiology of Eastern Equine Encephalitis Virus, New York |
title_full_unstemmed |
Molecular Epidemiology of Eastern Equine Encephalitis Virus, New York |
title_sort |
molecular epidemiology of eastern equine encephalitis virus, new york |
publisher |
Centers for Disease Control and Prevention |
series |
Emerging Infectious Diseases |
issn |
1080-6040 1080-6059 |
publishDate |
2008-03-01 |
description |
Perpetuation, overwintering, and extinction of eastern equine encephalitis virus (EEEV) in northern foci are poorly understood. We therefore sought to describe the molecular epidemiology of EEEV in New York State during current and past epizootics. To determine whether EEEV overwinters, is periodically reintroduced, or both, we sequenced the E2 and partial NSP3 coding regions of 42 EEEV isolates from New York State and the Eastern Seaboard of the United States. Our phylogenetic analyses indicated that derived subclades tended to contain southern strains that had been isolated before genetically similar northern strains, suggesting southern to northern migration of EEEV along the Eastern Seaboard. Strong clustering among strains isolated during epizootics in New York from 2003–2005, as well as from 1974–1975, demonstrates that EEEV has overwintered in this focus. This study provides molecular evidence for the introduction of southern EEEV strains to New York, followed by local amplification, perpetuation, and overwintering. |
topic |
Eastern equine encephalitis virus, Alphavirus, Togaviridae, Arboviruses, epidemiology, molecular research New York United States |
url |
https://wwwnc.cdc.gov/eid/article/14/3/07-0816_article |
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