Dynamic Changes of Arc Expression in Dorsal Striatum of Mice After Self-Administration of Sucrose
Region-specific plasticity in the striatal circuit plays an important role in the development and long-term maintenance of skills and sequential movement procedures. Studies investigating the molecular substrates that contribute to the plasticity changes during motor skill processes have documented...
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doaj-0c7e3fdd247644e19bbeca3f415722632021-05-19T05:08:07ZengFrontiers Media S.A.Frontiers in Cellular Neuroscience1662-51022021-05-011510.3389/fncel.2021.654521654521Dynamic Changes of Arc Expression in Dorsal Striatum of Mice After Self-Administration of SucroseXue Li0Jing-Wang Zhao1Qian Ding2Cheng Wu3Wan-Qi Li4Yan-Chen Guo5Di Wang6Guang-Qing Xu7Ti-Fei Yuan8Ti-Fei Yuan9Ti-Fei Yuan10Wan-Kun Gong11Yue Lan12Yue Lan13Department of Rehabilitation Medicine, Guangzhou First People’s Hospital, Guangzhou Medical University, Guangzhou, ChinaSchool of Rehabilitation Science, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaDepartment of Rehabilitation Medicine, Guangzhou First People’s Hospital, School of Medicine, South China University of Technology, Guangzhou, ChinaDepartment of Rehabilitation Medicine, Guangzhou First People’s Hospital, School of Medicine, South China University of Technology, Guangzhou, ChinaDepartment of Rehabilitation Medicine, Guangzhou First People’s Hospital, Guangzhou Medical University, Guangzhou, ChinaShanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaShanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDepartment of Rehabilitation Medicine, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, ChinaShanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaTranslational Research Institute of Brain and Brain-Like Intelligence, Shanghai Fourth People’s Hospital Affiliated to Tongji University School of Medicine, Shanghai, ChinaCo-innovation Center of Neuroregeneration, Natong University, Nantong, ChinaShanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDepartment of Rehabilitation Medicine, Guangzhou First People’s Hospital, Guangzhou Medical University, Guangzhou, ChinaDepartment of Rehabilitation Medicine, Guangzhou First People’s Hospital, School of Medicine, South China University of Technology, Guangzhou, ChinaRegion-specific plasticity in the striatal circuit plays an important role in the development and long-term maintenance of skills and sequential movement procedures. Studies investigating the molecular substrates that contribute to the plasticity changes during motor skill processes have documented a transition in expression from the dorsomedial striatum (DMS) to the dorsolateral striatum (DLS); however, few studies have explored the expression pattern of molecular substrates in the dorsal striatum during progression of instrumental learning. To address this issue, the activity-regulated cytoskeleton-associated protein (Arc) expressions in the subregional dorsal striatum were analyzed during the early and late learning phases of the 10-day sucrose self-administration process. We found that Arc protein is primarily detected in the DMS only in the initial learning stage; however, it is expressed in the DLS during both early and late learning stages. Moreover, Arc expression in the DMS correlated with the number of rewards received later in the training. These data indicated that the Arc expression in subregions of the dorsal striatum shows region-specific transfer and that Arc expression in the DMS contributes to obtaining reward in later learning stage during the process of instrumental learning.https://www.frontiersin.org/articles/10.3389/fncel.2021.654521/fullArcthe dorsomedial striatumthe dorsolateral striatuminstrumental learningself-administration |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Xue Li Jing-Wang Zhao Qian Ding Cheng Wu Wan-Qi Li Yan-Chen Guo Di Wang Guang-Qing Xu Ti-Fei Yuan Ti-Fei Yuan Ti-Fei Yuan Wan-Kun Gong Yue Lan Yue Lan |
spellingShingle |
Xue Li Jing-Wang Zhao Qian Ding Cheng Wu Wan-Qi Li Yan-Chen Guo Di Wang Guang-Qing Xu Ti-Fei Yuan Ti-Fei Yuan Ti-Fei Yuan Wan-Kun Gong Yue Lan Yue Lan Dynamic Changes of Arc Expression in Dorsal Striatum of Mice After Self-Administration of Sucrose Frontiers in Cellular Neuroscience Arc the dorsomedial striatum the dorsolateral striatum instrumental learning self-administration |
author_facet |
Xue Li Jing-Wang Zhao Qian Ding Cheng Wu Wan-Qi Li Yan-Chen Guo Di Wang Guang-Qing Xu Ti-Fei Yuan Ti-Fei Yuan Ti-Fei Yuan Wan-Kun Gong Yue Lan Yue Lan |
author_sort |
Xue Li |
title |
Dynamic Changes of Arc Expression in Dorsal Striatum of Mice After Self-Administration of Sucrose |
title_short |
Dynamic Changes of Arc Expression in Dorsal Striatum of Mice After Self-Administration of Sucrose |
title_full |
Dynamic Changes of Arc Expression in Dorsal Striatum of Mice After Self-Administration of Sucrose |
title_fullStr |
Dynamic Changes of Arc Expression in Dorsal Striatum of Mice After Self-Administration of Sucrose |
title_full_unstemmed |
Dynamic Changes of Arc Expression in Dorsal Striatum of Mice After Self-Administration of Sucrose |
title_sort |
dynamic changes of arc expression in dorsal striatum of mice after self-administration of sucrose |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Cellular Neuroscience |
issn |
1662-5102 |
publishDate |
2021-05-01 |
description |
Region-specific plasticity in the striatal circuit plays an important role in the development and long-term maintenance of skills and sequential movement procedures. Studies investigating the molecular substrates that contribute to the plasticity changes during motor skill processes have documented a transition in expression from the dorsomedial striatum (DMS) to the dorsolateral striatum (DLS); however, few studies have explored the expression pattern of molecular substrates in the dorsal striatum during progression of instrumental learning. To address this issue, the activity-regulated cytoskeleton-associated protein (Arc) expressions in the subregional dorsal striatum were analyzed during the early and late learning phases of the 10-day sucrose self-administration process. We found that Arc protein is primarily detected in the DMS only in the initial learning stage; however, it is expressed in the DLS during both early and late learning stages. Moreover, Arc expression in the DMS correlated with the number of rewards received later in the training. These data indicated that the Arc expression in subregions of the dorsal striatum shows region-specific transfer and that Arc expression in the DMS contributes to obtaining reward in later learning stage during the process of instrumental learning. |
topic |
Arc the dorsomedial striatum the dorsolateral striatum instrumental learning self-administration |
url |
https://www.frontiersin.org/articles/10.3389/fncel.2021.654521/full |
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