Signal Transducer and Activator of Transcription 3 Hyperactivation Associates With Follicular Helper T Cell Differentiation and Disease Activity in Rheumatoid Arthritis

Signal Transducer and Activator of Transcription 3 Hyperactivation Associates With Follicular Helper T Cell Differentiation and Disease Activity in Rheumatoid Arthritis

Follicular helper T (Tfh) cells are the specialized CD4+ T cell subset that supports B cells to produce high-affinity antibodies and generate humoral memory. Not only is the function of Tfh cells instrumental to mount protect antibodies but also to support autoantibody production and promote systemi...

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Bibliographic Details
Main Authors: Jun Deng, Chaofan Fan, Xin Gao, Qunxiong Zeng, Ruru Guo, Yunbo Wei, Zhian Chen, Yanan Chen, Dongcheng Gong, Jia Feng, Yan Xia, Shifei Xiang, Shushi Gong, Lin Yuan, Wei Shen, Wenyan Shen, Lin Lin, Ting Jiang, Dongyi He, Liangjing Lu, Xiaoxiang Chen, Di Yu
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-06-01
Series:Frontiers in Immunology
Subjects:
rheumatoid arthritis
patient
follicular helper T cells
signal transducer and activator of transcription 3
phosphorylation
IL-6
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.01226/full

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