Arterial Stiffness and Dialysis Calcium Concentration
Arterial stiffness is the major determinant of isolated systolic hypertension and increased pulse pressure. Aortic stiffness is also associated with increased cardiovascular morbidity and mortality in patients with chronic kidney disease, hypertension, and general population. Hemodynamically, arteri...
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doaj-0c8e56e08900424fbe87d5d406ee39c72020-11-25T02:00:10ZengHindawi LimitedInternational Journal of Nephrology2090-214X2090-21582011-01-01201110.4061/2011/839793839793Arterial Stiffness and Dialysis Calcium ConcentrationFabrice Mac-Way0Amélie Leboeuf1Mohsen Agharazii2Division of Nephrology and Research Center of CHUQ, L'Hôtel Dieu de Québec Hospital and Faculty of Medicine, Laval University, Quebec, QC, G1R 2J6, CanadaDivision of Nephrology and Research Center of CHUQ, L'Hôtel Dieu de Québec Hospital and Faculty of Medicine, Laval University, Quebec, QC, G1R 2J6, CanadaDivision of Nephrology and Research Center of CHUQ, L'Hôtel Dieu de Québec Hospital and Faculty of Medicine, Laval University, Quebec, QC, G1R 2J6, CanadaArterial stiffness is the major determinant of isolated systolic hypertension and increased pulse pressure. Aortic stiffness is also associated with increased cardiovascular morbidity and mortality in patients with chronic kidney disease, hypertension, and general population. Hemodynamically, arterial stiffness results in earlier aortic pulse wave reflection leading to increased cardiac workload and decreased myocardial perfusion. Although the clinical consequence of aortic stiffness has been clearly established, its pathophysiology in various clinical conditions still remains poorly understood. The aim of the present paper is to review the studies that have looked at the impact of dialysis calcium concentration on arterial stiffness. Overall, the results of small short-term studies suggest that higher dialysis calcium is associated with a transient but significant increase in arterial stiffness. This calcium dependant increase in arterial stiffness is potentially explained by increased vascular smooth muscle tone of the conduit arteries and is not solely explained by changes in mean blood pressure. However, the optimal DCa remains to be determined, and long term studies are required to evaluate its impact on the progression of arterial stiffness.http://dx.doi.org/10.4061/2011/839793 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Fabrice Mac-Way Amélie Leboeuf Mohsen Agharazii |
spellingShingle |
Fabrice Mac-Way Amélie Leboeuf Mohsen Agharazii Arterial Stiffness and Dialysis Calcium Concentration International Journal of Nephrology |
author_facet |
Fabrice Mac-Way Amélie Leboeuf Mohsen Agharazii |
author_sort |
Fabrice Mac-Way |
title |
Arterial Stiffness and Dialysis Calcium Concentration |
title_short |
Arterial Stiffness and Dialysis Calcium Concentration |
title_full |
Arterial Stiffness and Dialysis Calcium Concentration |
title_fullStr |
Arterial Stiffness and Dialysis Calcium Concentration |
title_full_unstemmed |
Arterial Stiffness and Dialysis Calcium Concentration |
title_sort |
arterial stiffness and dialysis calcium concentration |
publisher |
Hindawi Limited |
series |
International Journal of Nephrology |
issn |
2090-214X 2090-2158 |
publishDate |
2011-01-01 |
description |
Arterial stiffness is the major determinant of isolated systolic hypertension and increased pulse pressure. Aortic stiffness is also associated with increased cardiovascular morbidity and mortality in patients with chronic kidney disease, hypertension, and general population. Hemodynamically, arterial stiffness results in earlier aortic pulse wave reflection leading to increased cardiac workload and decreased myocardial perfusion. Although the clinical consequence of aortic stiffness has been clearly established, its pathophysiology in various clinical conditions still remains poorly understood. The aim of the present paper is to review the studies that have looked at the impact of dialysis calcium concentration on arterial stiffness. Overall, the results of small short-term studies suggest that higher dialysis calcium is associated with a transient but significant increase in arterial stiffness. This calcium dependant increase in arterial stiffness is potentially explained by increased vascular smooth muscle tone of the conduit arteries and is not solely explained by changes in mean blood pressure. However, the optimal DCa remains to be determined, and long term studies are required to evaluate its impact on the progression of arterial stiffness. |
url |
http://dx.doi.org/10.4061/2011/839793 |
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