DNA Methylation, Mechanisms of <i>FMR1</i> Inactivation and Therapeutic Perspectives for Fragile X Syndrome

DNA Methylation, Mechanisms of <i>FMR1</i> Inactivation and Therapeutic Perspectives for Fragile X Syndrome

Among the inherited causes of intellectual disability and autism, Fragile X syndrome (FXS) is the most frequent form, for which there is currently no cure. In most FXS patients, the <i>FMR1</i> gene is epigenetically inactivated following the expansion over 200 triplets of a CGG repeat (...

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Bibliographic Details
Main Authors: Veronica Nobile, Cecilia Pucci, Pietro Chiurazzi, Giovanni Neri, Elisabetta Tabolacci
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:Biomolecules
Subjects:
fragile X syndrome
<i>FMR1</i> gene
epigenetic modifications
DNA methylation
gene expression signatures
Online Access:https://www.mdpi.com/2218-273X/11/2/296

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