Management of Infants with Brief Resolved Unexplained Events (BRUE) and Apparent Life-Threatening Events (ALTE): A RAND/UCLA Appropriateness Approach

• Main Authors: Giovanni Prezioso, Serafina Perrone, Giacomo Biasucci, Giovanna Pisi, Valentina Fainardi, Caterina Strisciuglio, Francesco Nonnis Marzano, Sabrina Moretti, Francesco Pisani, Bertrand Tchana, Alberto Argentiero, Cosimo Neglia, Carlo Caffarelli, Patrizia Bertolini, Maria Teresa Bersini, Andrea Canali, Emanuele Voccia, Antonella Squarcia, Tullio Ghi, Carla Verrotti, Tiziana Frusca, Rossana Cecchi, Giovanna Giordano, Filomena Colasanti, Ilenia Roccia, Paola Palanza, Susanna Esposito
• Format: Article
• Language: English
• Published: MDPI AG 2021-02-01
• Series: Life
• Subjects: ALTE; BRUE; pediatric emergency; RAND/UCLA appropriateness method; SIDS
• Online Access: https://www.mdpi.com/2075-1729/11/2/171

Unexpected events of breath, tone, and skin color change in infants are a cause of considerable distress to the caregiver and there is still debate on their appropriate management. The aim of this study is to survey the trend in prevention, decision-making, and management of brief resolved unexplained events (BRUE)/apparent life-threatening events (ALTE) and to develop a shared protocol among hospitals and primary care pediatricians regarding hospital admission criteria, work-up and post-discharge monitoring of patients with BRUE/ALTE. For the study purpose, a panel of 54 experts was selected to achieve consensus using the RAND/UCLA appropriateness method. Twelve scenarios were developed: one addressed to primary prevention of ALTE and BRUE, and 11 focused on hospital management of BRUE and ALTE. For each scenario, participants were asked to rank each option from ‘1’ (extremely inappropriate) to ‘9’ (extremely appropriate). Results derived from panel meeting and discussion showed several points of agreement but also disagreement with different opinion emerged and the need of focused education on some areas. However, by combining previous recommendations with expert opinion, the application of the RAND/UCLA appropriateness permitted us to drive pediatricians to reasoned and informed decisions in term of evaluation, treatment and follow-up of infants with BRUE/ALTE, reducing inappropriate exams and hospitalisation and highlighting priorities for educational interventions.