Correlation of chromosomal instability, telomere length and telomere maintenance in microsatellite stable rectal cancer: a molecular subclass of rectal cancer.

Correlation of chromosomal instability, telomere length and telomere maintenance in microsatellite stable rectal cancer: a molecular subclass of rectal cancer.

<h4>Introduction</h4>Colorectal cancer (CRC) tumor DNA is characterized by chromosomal damage termed chromosomal instability (CIN) and excessively shortened telomeres. Up to 80% of CRC is microsatellite stable (MSS) and is historically considered to be chromosomally unstable (CIN+). Howe...

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Main Authors: Lisa A Boardman, Ruth A Johnson, Kimberly B Viker, Kari A Hafner, Robert B Jenkins, Douglas L Riegert-Johnson, Thomas C Smyrk, Kristin Litzelman, Songwon Seo, Ronald E Gangnon, Corinne D Engelman, David N Rider, Russell J Vanderboom, Stephen N Thibodeau, Gloria M Petersen, Halcyon G Skinner
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24278232/pdf/?tool=EBI

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