Some problems and errors in cytogenetic biodosimetry
Human radiosensitivity is a quantitative trait that is generally subject to binomial distribution. Individual radiosensitivity, however, may deviate significantly from the mean (by 2–3 standard deviations). Thus, the same dose of radiation may result in different levels of genotoxic damage (commonly...
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doaj-0cc0b03253014198a742cfa18aa2749e2020-11-25T02:07:55ZengTaylor & Francis GroupBiotechnology & Biotechnological Equipment1310-28181314-35302017-05-0131346046810.1080/13102818.2016.12590181259018Some problems and errors in cytogenetic biodosimetryIrma Mosse0Alexander Kilchevsky1Nevena Nikolova2Nikolai Zhelev3Institute of Genetics and CytologyInstitute of Genetics and CytologyTrakia UniversityAbertay UniversityHuman radiosensitivity is a quantitative trait that is generally subject to binomial distribution. Individual radiosensitivity, however, may deviate significantly from the mean (by 2–3 standard deviations). Thus, the same dose of radiation may result in different levels of genotoxic damage (commonly measured as chromosome aberration rates) in different individuals. There is significant genetic component in individual radiosensitivity. It is related to carriership of variant alleles of various single-nucleotide polymorphisms (most of these in genes coding for proteins functioning in DNA damage identification and repair); carriership of a different number of alleles producing cumulative effects; amplification of gene copies coding for proteins responsible for radioresistance, mobile genetic elements and others. Among the other factors influencing individual radioresistance are: the radioadaptive response; the bystander effect; the levels of endogenous substances with radioprotective and antimutagenic properties and environmental factors such as lifestyle and diet, physical activity, psychoemotional state, hormonal state, certain drugs, infections and others. These factors may have radioprotective or sensibilizing effects. Apparently, there are too many factors that may significantly modulate the biological effects of ionizing radiation. Thus, conventional methodologies for biodosimetry (specifically, cytogenetic methods) may produce significant errors if personal traits that may affect radioresistance are not accounted for.http://dx.doi.org/10.1080/13102818.2016.1259018Biodosimetry errorsradiosensitivitygenetic variationenvironmental factors |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Irma Mosse Alexander Kilchevsky Nevena Nikolova Nikolai Zhelev |
spellingShingle |
Irma Mosse Alexander Kilchevsky Nevena Nikolova Nikolai Zhelev Some problems and errors in cytogenetic biodosimetry Biotechnology & Biotechnological Equipment Biodosimetry errors radiosensitivity genetic variation environmental factors |
author_facet |
Irma Mosse Alexander Kilchevsky Nevena Nikolova Nikolai Zhelev |
author_sort |
Irma Mosse |
title |
Some problems and errors in cytogenetic biodosimetry |
title_short |
Some problems and errors in cytogenetic biodosimetry |
title_full |
Some problems and errors in cytogenetic biodosimetry |
title_fullStr |
Some problems and errors in cytogenetic biodosimetry |
title_full_unstemmed |
Some problems and errors in cytogenetic biodosimetry |
title_sort |
some problems and errors in cytogenetic biodosimetry |
publisher |
Taylor & Francis Group |
series |
Biotechnology & Biotechnological Equipment |
issn |
1310-2818 1314-3530 |
publishDate |
2017-05-01 |
description |
Human radiosensitivity is a quantitative trait that is generally subject to binomial distribution. Individual radiosensitivity, however, may deviate significantly from the mean (by 2–3 standard deviations). Thus, the same dose of radiation may result in different levels of genotoxic damage (commonly measured as chromosome aberration rates) in different individuals. There is significant genetic component in individual radiosensitivity. It is related to carriership of variant alleles of various single-nucleotide polymorphisms (most of these in genes coding for proteins functioning in DNA damage identification and repair); carriership of a different number of alleles producing cumulative effects; amplification of gene copies coding for proteins responsible for radioresistance, mobile genetic elements and others. Among the other factors influencing individual radioresistance are: the radioadaptive response; the bystander effect; the levels of endogenous substances with radioprotective and antimutagenic properties and environmental factors such as lifestyle and diet, physical activity, psychoemotional state, hormonal state, certain drugs, infections and others. These factors may have radioprotective or sensibilizing effects. Apparently, there are too many factors that may significantly modulate the biological effects of ionizing radiation. Thus, conventional methodologies for biodosimetry (specifically, cytogenetic methods) may produce significant errors if personal traits that may affect radioresistance are not accounted for. |
topic |
Biodosimetry errors radiosensitivity genetic variation environmental factors |
url |
http://dx.doi.org/10.1080/13102818.2016.1259018 |
work_keys_str_mv |
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