Altered Venous Function during Long-Duration Spaceflights
Aims: Venous adaptation to microgravity, associated with cardiovascular deconditioning, may contribute to orthostatic intolerance following spaceflight. The aim of this study was to analyze the main parameters of venous hemodynamics with long-duration spaceflight.Methods: Venous plethysmography was...
Main Authors: | , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2017-09-01
|
Series: | Frontiers in Physiology |
Subjects: | |
Online Access: | http://journal.frontiersin.org/article/10.3389/fphys.2017.00694/full |
id |
doaj-0cd09ece7f934dddb1e4febc7ebf2308 |
---|---|
record_format |
Article |
spelling |
doaj-0cd09ece7f934dddb1e4febc7ebf23082020-11-25T00:02:13ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2017-09-01810.3389/fphys.2017.00694275290Altered Venous Function during Long-Duration SpaceflightsJacques-Olivier Fortrat0Ana de Holanda1Kathryn Zuj2Guillemette Gauquelin-Koch3Claude Gharib4UMR Centre National de la Recherche Scientifique, Faculté de Médecine d'Angers, 6214 Institut National de la Santé et de la Recherche Médicale, 1083 (Biologie Neurovasculaire et Mitochondriale Intégrée)Angers, FranceUMR Centre National de la Recherche Scientifique, Faculté de Médecine d'Angers, 6214 Institut National de la Santé et de la Recherche Médicale, 1083 (Biologie Neurovasculaire et Mitochondriale Intégrée)Angers, FranceFaculty of Applied Health Sciences, University of WaterlooWaterloo, ON, CanadaCentre Nationale d'Etudes SpatialesParis, FranceFaculté de Médecine Lyon Est, Université Claude Bernard Lyon 1Lyon, FranceAims: Venous adaptation to microgravity, associated with cardiovascular deconditioning, may contribute to orthostatic intolerance following spaceflight. The aim of this study was to analyze the main parameters of venous hemodynamics with long-duration spaceflight.Methods: Venous plethysmography was performed on 24 cosmonauts before, during, and after spaceflights aboard the International Space Station. Venous plethysmography assessed venous filling and emptying functions as well as microvascular filtration, in response to different levels of venous occlusion pressure. Calf volume was assessed using calf circumference measurements.Results: Calf volume decreased during spaceflight from 2.3 ± 0.3 to 1.7 ± 0.2 L (p < 0.001), and recovered after it (2.3 ± 0.3 L). Venous compliance, determined as the relationship between occlusion pressure and the change in venous volume, increased during spaceflight from 0.090 ± 0.005 to 0.120 ± 0.007 (p < 0.01) and recovered 8 days after landing (0.071 ± 0.005, arbitrary units). The index of venous emptying rate decreased during spaceflight from −0.004 ± 0.022 to −0.212 ± 0.033 (p < 0.001, arbitrary units). The index of vascular microfiltration increased during spaceflight from 6.1 ± 1.8 to 10.6 ± 7.9 (p < 0.05, arbitrary units).Conclusion: This study demonstrated that overall venous function is changed during spaceflight. In future, venous function should be considered when developing countermeasures to prevent cardiovascular deconditioning and orthostatic intolerance with long-duration spaceflight.http://journal.frontiersin.org/article/10.3389/fphys.2017.00694/fullblood volumecardiovascular deconditioningmicrogravityvenous plethysmography |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jacques-Olivier Fortrat Ana de Holanda Kathryn Zuj Guillemette Gauquelin-Koch Claude Gharib |
spellingShingle |
Jacques-Olivier Fortrat Ana de Holanda Kathryn Zuj Guillemette Gauquelin-Koch Claude Gharib Altered Venous Function during Long-Duration Spaceflights Frontiers in Physiology blood volume cardiovascular deconditioning microgravity venous plethysmography |
author_facet |
Jacques-Olivier Fortrat Ana de Holanda Kathryn Zuj Guillemette Gauquelin-Koch Claude Gharib |
author_sort |
Jacques-Olivier Fortrat |
title |
Altered Venous Function during Long-Duration Spaceflights |
title_short |
Altered Venous Function during Long-Duration Spaceflights |
title_full |
Altered Venous Function during Long-Duration Spaceflights |
title_fullStr |
Altered Venous Function during Long-Duration Spaceflights |
title_full_unstemmed |
Altered Venous Function during Long-Duration Spaceflights |
title_sort |
altered venous function during long-duration spaceflights |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Physiology |
issn |
1664-042X |
publishDate |
2017-09-01 |
description |
Aims: Venous adaptation to microgravity, associated with cardiovascular deconditioning, may contribute to orthostatic intolerance following spaceflight. The aim of this study was to analyze the main parameters of venous hemodynamics with long-duration spaceflight.Methods: Venous plethysmography was performed on 24 cosmonauts before, during, and after spaceflights aboard the International Space Station. Venous plethysmography assessed venous filling and emptying functions as well as microvascular filtration, in response to different levels of venous occlusion pressure. Calf volume was assessed using calf circumference measurements.Results: Calf volume decreased during spaceflight from 2.3 ± 0.3 to 1.7 ± 0.2 L (p < 0.001), and recovered after it (2.3 ± 0.3 L). Venous compliance, determined as the relationship between occlusion pressure and the change in venous volume, increased during spaceflight from 0.090 ± 0.005 to 0.120 ± 0.007 (p < 0.01) and recovered 8 days after landing (0.071 ± 0.005, arbitrary units). The index of venous emptying rate decreased during spaceflight from −0.004 ± 0.022 to −0.212 ± 0.033 (p < 0.001, arbitrary units). The index of vascular microfiltration increased during spaceflight from 6.1 ± 1.8 to 10.6 ± 7.9 (p < 0.05, arbitrary units).Conclusion: This study demonstrated that overall venous function is changed during spaceflight. In future, venous function should be considered when developing countermeasures to prevent cardiovascular deconditioning and orthostatic intolerance with long-duration spaceflight. |
topic |
blood volume cardiovascular deconditioning microgravity venous plethysmography |
url |
http://journal.frontiersin.org/article/10.3389/fphys.2017.00694/full |
work_keys_str_mv |
AT jacquesolivierfortrat alteredvenousfunctionduringlongdurationspaceflights AT anadeholanda alteredvenousfunctionduringlongdurationspaceflights AT kathrynzuj alteredvenousfunctionduringlongdurationspaceflights AT guillemettegauquelinkoch alteredvenousfunctionduringlongdurationspaceflights AT claudegharib alteredvenousfunctionduringlongdurationspaceflights |
_version_ |
1725438865525702656 |