Signs of Selection in Synonymous Sites of the Mitochondrial Cytochrome b Gene of Baikal Oilfish (Comephoridae) by mRNA Secondary Structure Alterations
Studies over the past decade have shown a significant role of synonymous mutations in posttranscriptional regulation of gene expression, which is particularly associated with messenger RNA (mRNA) secondary structure alterations. Most studies focused on prokaryote genomes and the nuclear genomes of e...
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Online Access: | http://dx.doi.org/10.1155/2015/387913 |
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doaj-0cd20fd5928f4fd5bf01cdbf5ee3bdfd2020-11-24T22:31:53ZengHindawi LimitedBioMed Research International2314-61332314-61412015-01-01201510.1155/2015/387913387913Signs of Selection in Synonymous Sites of the Mitochondrial Cytochrome b Gene of Baikal Oilfish (Comephoridae) by mRNA Secondary Structure AlterationsVeronika I. Teterina0Anatoliy M. Mamontov1Lyubov V. Sukhanova2Sergei V. Kirilchik3Limnological Institute, Siberian Branch, Russian Academy of Sciences, P.O. Box 278, Irkutsk 664033, RussiaLimnological Institute, Siberian Branch, Russian Academy of Sciences, P.O. Box 278, Irkutsk 664033, RussiaLimnological Institute, Siberian Branch, Russian Academy of Sciences, P.O. Box 278, Irkutsk 664033, RussiaLimnological Institute, Siberian Branch, Russian Academy of Sciences, P.O. Box 278, Irkutsk 664033, RussiaStudies over the past decade have shown a significant role of synonymous mutations in posttranscriptional regulation of gene expression, which is particularly associated with messenger RNA (mRNA) secondary structure alterations. Most studies focused on prokaryote genomes and the nuclear genomes of eukaryotes while little is known about the regulation of mitochondrial DNA (mtDNA) gene expression. This paper reveals signs of selection in synonymous sites of the mitochondrial cytochrome b gene (Cytb) of Baikal oilfish or golomyankas (Comephoridae) directed towards altering the secondary structure of the mRNA and probably altering the character of mtDNA gene expression. Our findings are based on comparisons of intraspecific genetic variation patterns of small golomyanka (Comephorus dybowski) and two genetic groups of big golomyanka (Comephorus dybowskii). Two approaches were used: (i) analysis of the distribution of synonymous mutations between weak-AT (W) and strong-GC (S) nucleotides within species and groups in accordance with mutation directions from central to peripheral haplotypes and (ii) approaches based on the predicted mRNA secondary structure.http://dx.doi.org/10.1155/2015/387913 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Veronika I. Teterina Anatoliy M. Mamontov Lyubov V. Sukhanova Sergei V. Kirilchik |
spellingShingle |
Veronika I. Teterina Anatoliy M. Mamontov Lyubov V. Sukhanova Sergei V. Kirilchik Signs of Selection in Synonymous Sites of the Mitochondrial Cytochrome b Gene of Baikal Oilfish (Comephoridae) by mRNA Secondary Structure Alterations BioMed Research International |
author_facet |
Veronika I. Teterina Anatoliy M. Mamontov Lyubov V. Sukhanova Sergei V. Kirilchik |
author_sort |
Veronika I. Teterina |
title |
Signs of Selection in Synonymous Sites of the Mitochondrial Cytochrome b Gene of Baikal Oilfish (Comephoridae) by mRNA Secondary Structure Alterations |
title_short |
Signs of Selection in Synonymous Sites of the Mitochondrial Cytochrome b Gene of Baikal Oilfish (Comephoridae) by mRNA Secondary Structure Alterations |
title_full |
Signs of Selection in Synonymous Sites of the Mitochondrial Cytochrome b Gene of Baikal Oilfish (Comephoridae) by mRNA Secondary Structure Alterations |
title_fullStr |
Signs of Selection in Synonymous Sites of the Mitochondrial Cytochrome b Gene of Baikal Oilfish (Comephoridae) by mRNA Secondary Structure Alterations |
title_full_unstemmed |
Signs of Selection in Synonymous Sites of the Mitochondrial Cytochrome b Gene of Baikal Oilfish (Comephoridae) by mRNA Secondary Structure Alterations |
title_sort |
signs of selection in synonymous sites of the mitochondrial cytochrome b gene of baikal oilfish (comephoridae) by mrna secondary structure alterations |
publisher |
Hindawi Limited |
series |
BioMed Research International |
issn |
2314-6133 2314-6141 |
publishDate |
2015-01-01 |
description |
Studies over the past decade have shown a significant role of synonymous mutations in posttranscriptional regulation of gene expression, which is particularly associated with messenger RNA (mRNA) secondary structure alterations. Most studies focused on prokaryote genomes and the nuclear genomes of eukaryotes while little is known about the regulation of mitochondrial DNA (mtDNA) gene expression. This paper reveals signs of selection in synonymous sites of the mitochondrial cytochrome b gene (Cytb) of Baikal oilfish or golomyankas (Comephoridae) directed towards altering the secondary structure of the mRNA and probably altering the character of mtDNA gene expression. Our findings are based on comparisons of intraspecific genetic variation patterns of small golomyanka (Comephorus dybowski) and two genetic groups of big golomyanka (Comephorus dybowskii). Two approaches were used: (i) analysis of the distribution of synonymous mutations between weak-AT (W) and strong-GC (S) nucleotides within species and groups in accordance with mutation directions from central to peripheral haplotypes and (ii) approaches based on the predicted mRNA secondary structure. |
url |
http://dx.doi.org/10.1155/2015/387913 |
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