Recent advances in understanding and treating chronic granulomatous disease [version 1; referees: 4 approved]

• Main Author: Andrew Gennery
• Format: Article
• Language: English
• Published: F1000 Research Ltd 2017-08-01
• Series: F1000Research
• Subjects: Bacterial Infections; Cellular Microbiology & Pathogenesis; Clinical Immunology; Endocrine & Metabolic Pharmacology; Environmental Microbiology; Fungal Infections; Gastrointestinal Physiology; Genetics of the Immune System; Immunity to Infections; Immunopharmacology & Hematologic Pharmacology; Inflammatory Bowel Disease; Innate Immunity; Leukocyte Development; Medical Genetics; Medical Microbiology; Respiratory Infections; Stem Cells & Regeneration
• Online Access: https://f1000research.com/articles/6-1427/v1

A number of recent advances have been made in the epidemiology and treatment of chronic granulomatous disease. Several reports from developing regions describe the presentations and progress of local populations, highlighting complications due to Bacillus Calmette–Guérin vaccination. A number of new reports describe complications of chronic granulomatous disease in adult patients, as more survivors reach adulthood. The complications experienced by X-linked carriers are particularly highlighted in three new reports, confirming that infection and inflammatory or autoimmune conditions are more common and severe than previously recognised. Finally, definitive treatment with haematopoietic stem cell transplantation and gene therapy is reviewed.