SIKs control osteocyte responses to parathyroid hormone
Parathyroid hormone (PTH) is an endogenous hormone and osteoporosis therapeutic that suppresses sclerostin activity. Here the authors develop SIK inhibitors as potential therapeutic tools and use them to show that PTH-cAMP signalling in osteocytes inhibits SIK2 from driving Hdac4/5 nuclear shuttling...
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Bibliographic Details
Main Authors: |
Marc N. Wein,
Yanke Liang,
Olga Goransson,
Thomas B. Sundberg,
Jinhua Wang,
Elizabeth A. Williams,
Maureen J. O’Meara,
Nicolas Govea,
Belinda Beqo,
Shigeki Nishimori,
Kenichi Nagano,
Daniel J. Brooks,
Janaina S. Martins,
Braden Corbin,
Anthony Anselmo,
Ruslan Sadreyev,
Joy Y. Wu,
Kei Sakamoto,
Marc Foretz,
Ramnik J. Xavier,
Roland Baron,
Mary L. Bouxsein,
Thomas J. Gardella,
Paola Divieti-Pajevic,
Nathanael S. Gray,
Henry M. Kronenberg |
Format: | Article
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Language: | English |
Published: |
Nature Publishing Group
2016-10-01
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Series: | Nature Communications
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Online Access: | https://doi.org/10.1038/ncomms13176
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