SIKs control osteocyte responses to parathyroid hormone
Parathyroid hormone (PTH) is an endogenous hormone and osteoporosis therapeutic that suppresses sclerostin activity. Here the authors develop SIK inhibitors as potential therapeutic tools and use them to show that PTH-cAMP signalling in osteocytes inhibits SIK2 from driving Hdac4/5 nuclear shuttling...
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Nature Publishing Group
2016-10-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms13176 |
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doaj-0cde2d55d46f474080f0807c4fb646c22021-05-11T10:50:14ZengNature Publishing GroupNature Communications2041-17232016-10-017111910.1038/ncomms13176SIKs control osteocyte responses to parathyroid hormoneMarc N. Wein0Yanke Liang1Olga Goransson2Thomas B. Sundberg3Jinhua Wang4Elizabeth A. Williams5Maureen J. O’Meara6Nicolas Govea7Belinda Beqo8Shigeki Nishimori9Kenichi Nagano10Daniel J. Brooks11Janaina S. Martins12Braden Corbin13Anthony Anselmo14Ruslan Sadreyev15Joy Y. Wu16Kei Sakamoto17Marc Foretz18Ramnik J. Xavier19Roland Baron20Mary L. Bouxsein21Thomas J. Gardella22Paola Divieti-Pajevic23Nathanael S. Gray24Henry M. Kronenberg25Department of Medicine, Endocrine Unit, Massachusetts General Hospital, Harvard Medical SchoolDepartment of Biologic Chemistry and Molecular Pharmacology, Dana Farber Cancer Institute, Harvard Medical SchoolDepartment of Experimental Medical Sciences, Lund UniversityCenter for the Development of Therapeutics, Broad InstituteDepartment of Biologic Chemistry and Molecular Pharmacology, Dana Farber Cancer Institute, Harvard Medical SchoolDepartment of Medicine, Endocrine Unit, Massachusetts General Hospital, Harvard Medical SchoolDepartment of Medicine, Endocrine Unit, Massachusetts General Hospital, Harvard Medical SchoolDepartment of Medicine, Endocrine Unit, Massachusetts General Hospital, Harvard Medical SchoolDepartment of Medicine, Endocrine Unit, Massachusetts General Hospital, Harvard Medical SchoolDepartment of Medicine, Endocrine Unit, Massachusetts General Hospital, Harvard Medical SchoolDepartment of Oral Medicine, Harvard School of Dental Medicine, Infection, and Immunity, 188 Longwood Avenue, Boston, Massachusetts 02115, USDepartment of Medicine, Endocrine Unit, Massachusetts General Hospital, Harvard Medical SchoolDepartment of Medicine, Endocrine Unit, Massachusetts General Hospital, Harvard Medical SchoolDepartment of Medicine, Endocrine Unit, Massachusetts General Hospital, Harvard Medical SchoolDepartment of Molecular Biology, Massachusetts General Hospital, Harvard Medical SchoolDepartment of Molecular Biology, Massachusetts General Hospital, Harvard Medical SchoolDivision of Endocrinology, Department of Medicine, Stanford University School of MedicineMRC Protein Phosphorylation and Ubiquitylation Unit, College of Life Sciences, University of DundeeINSERM U1016, Institut Cochin, CNRS UMR8104, Universite Paris Descartes Sorbonne Pairs CiteDepartment of Medicine, Gastrointestinal Unit and Center for the Study of Inflammatory Bowel Disease, Massachusetts General HospitalDepartment of Medicine, Endocrine Unit, Massachusetts General Hospital, Harvard Medical SchoolDepartment of Medicine, Endocrine Unit, Massachusetts General Hospital, Harvard Medical SchoolDepartment of Medicine, Endocrine Unit, Massachusetts General Hospital, Harvard Medical SchoolHenry M. Goldman School of Dental Medicine, Boston UniversityDepartment of Biologic Chemistry and Molecular Pharmacology, Dana Farber Cancer Institute, Harvard Medical SchoolDepartment of Medicine, Endocrine Unit, Massachusetts General Hospital, Harvard Medical SchoolParathyroid hormone (PTH) is an endogenous hormone and osteoporosis therapeutic that suppresses sclerostin activity. Here the authors develop SIK inhibitors as potential therapeutic tools and use them to show that PTH-cAMP signalling in osteocytes inhibits SIK2 from driving Hdac4/5 nuclear shuttling to suppress sclerostin.https://doi.org/10.1038/ncomms13176 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Marc N. Wein Yanke Liang Olga Goransson Thomas B. Sundberg Jinhua Wang Elizabeth A. Williams Maureen J. O’Meara Nicolas Govea Belinda Beqo Shigeki Nishimori Kenichi Nagano Daniel J. Brooks Janaina S. Martins Braden Corbin Anthony Anselmo Ruslan Sadreyev Joy Y. Wu Kei Sakamoto Marc Foretz Ramnik J. Xavier Roland Baron Mary L. Bouxsein Thomas J. Gardella Paola Divieti-Pajevic Nathanael S. Gray Henry M. Kronenberg |
| spellingShingle |
Marc N. Wein Yanke Liang Olga Goransson Thomas B. Sundberg Jinhua Wang Elizabeth A. Williams Maureen J. O’Meara Nicolas Govea Belinda Beqo Shigeki Nishimori Kenichi Nagano Daniel J. Brooks Janaina S. Martins Braden Corbin Anthony Anselmo Ruslan Sadreyev Joy Y. Wu Kei Sakamoto Marc Foretz Ramnik J. Xavier Roland Baron Mary L. Bouxsein Thomas J. Gardella Paola Divieti-Pajevic Nathanael S. Gray Henry M. Kronenberg SIKs control osteocyte responses to parathyroid hormone Nature Communications |
| author_facet |
Marc N. Wein Yanke Liang Olga Goransson Thomas B. Sundberg Jinhua Wang Elizabeth A. Williams Maureen J. O’Meara Nicolas Govea Belinda Beqo Shigeki Nishimori Kenichi Nagano Daniel J. Brooks Janaina S. Martins Braden Corbin Anthony Anselmo Ruslan Sadreyev Joy Y. Wu Kei Sakamoto Marc Foretz Ramnik J. Xavier Roland Baron Mary L. Bouxsein Thomas J. Gardella Paola Divieti-Pajevic Nathanael S. Gray Henry M. Kronenberg |
| author_sort |
Marc N. Wein |
| title |
SIKs control osteocyte responses to parathyroid hormone |
| title_short |
SIKs control osteocyte responses to parathyroid hormone |
| title_full |
SIKs control osteocyte responses to parathyroid hormone |
| title_fullStr |
SIKs control osteocyte responses to parathyroid hormone |
| title_full_unstemmed |
SIKs control osteocyte responses to parathyroid hormone |
| title_sort |
siks control osteocyte responses to parathyroid hormone |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2016-10-01 |
| description |
Parathyroid hormone (PTH) is an endogenous hormone and osteoporosis therapeutic that suppresses sclerostin activity. Here the authors develop SIK inhibitors as potential therapeutic tools and use them to show that PTH-cAMP signalling in osteocytes inhibits SIK2 from driving Hdac4/5 nuclear shuttling to suppress sclerostin. |
| url |
https://doi.org/10.1038/ncomms13176 |
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