Dopamine D2-receptor knockout mice are protected against dopaminergic neurotoxicity induced by methamphetamine or MDMA

Dopamine D2-receptor knockout mice are protected against dopaminergic neurotoxicity induced by methamphetamine or MDMA

Methamphetamine (METH) and 3,4-methylenedioxymethamphetamine (MDMA), amphetamine derivatives widely used as recreational drugs, induce similar neurotoxic effects in mice, including a marked loss of tyrosine hydroxylase (TH) and dopamine transporter (DAT) in the striatum. Although the role of dopamin...

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Bibliographic Details
Main Authors: Noelia Granado, Sara Ares-Santos, Idaira Oliva, Esther O´Shea, Eduardo D. Martin, M. Isabel Colado, Rosario Moratalla
Format: Article
Language:English
Published: Elsevier 2011-06-01
Series:Neurobiology of Disease
Subjects:
Ecstasy
TH
DAT
Dopamine
Neurotoxicity
Neurodegeneration
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996111000544

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