Synthesis, Characterization and Antibacterial Studies of N-(Benzothiazol-2-yl)-4-chlorobenzenesulphonamide and Its Neodymium(III) and Thallium(III) Complexes
N-(Benzothiazol-2-yl)-4-chlorobenzenesulphonamide (NBTCS) was synthesized by condensation reaction of 4-chlorobenzenesulphonyl chloride and 2-aminobenzothiazole in acetone under reflux. Neodymium(III) and thallium(III) complexes of the ligand were also synthesized. Both ligand and metal complexes we...
Main Authors: | , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2017-02-01
|
Series: | Molecules |
Subjects: | |
Online Access: | http://www.mdpi.com/1420-3049/22/2/153 |
id |
doaj-0ce8b49089cc4785abdbae0cf972e5e0 |
---|---|
record_format |
Article |
spelling |
doaj-0ce8b49089cc4785abdbae0cf972e5e02020-11-24T21:40:21ZengMDPI AGMolecules1420-30492017-02-0122215310.3390/molecules22020153molecules22020153Synthesis, Characterization and Antibacterial Studies of N-(Benzothiazol-2-yl)-4-chlorobenzenesulphonamide and Its Neodymium(III) and Thallium(III) ComplexesLawrence Nnamdi Obasi0Uchechukwu Susan Oruma1Ibrahim Abdulrazak Al-Swaidan2Ponnadurai Ramasami3Chigozie Julius Ezeorah4Alfred Ezinna Ochonogor5Department of Pure and Industrial Chemistry, University of Nigeria, Nsukka 410001, NigeriaDepartment of Pure and Industrial Chemistry, University of Nigeria, Nsukka 410001, NigeriaDepartment of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi ArabiaComputational Chemistry Group, Department of Chemistry, Faculty of Science, University of Mauritius, Réduit 80837, MauritiusDepartment of Pure and Industrial Chemistry, University of Nigeria, Nsukka 410001, NigeriaDepartment of Pure and Industrial Chemistry, University of Nigeria, Nsukka 410001, NigeriaN-(Benzothiazol-2-yl)-4-chlorobenzenesulphonamide (NBTCS) was synthesized by condensation reaction of 4-chlorobenzenesulphonyl chloride and 2-aminobenzothiazole in acetone under reflux. Neodymium(III) and thallium(III) complexes of the ligand were also synthesized. Both ligand and metal complexes were characterized using UV-Vis, IR, 1H- and 13C-NMR spectroscopies, elemental analysis and molar conductance measurement. IR studies revealed that the ligand is tridentate and coordinates to the metal ions through nitrogen and oxygen atoms of the sulphonamide group and nitrogen atom attached to benzothiazole ring. The neodymium(III) complex displays a coordination number of eight while thallium(III) complex displays a coordination number of six. The ligand and its complexes were screened in vitro for their antibacterial activities against Escherichia coli strains (E. coli 6 and E. coli 13), Proteus species, Staphylococcus aureus and Pseudomonas aeruginosa using the agar well diffusion technique. The synthesized compounds were found to be more active against the microorganisms screened relative to ciprofloxacin, gentamicin and co-trimoxazole.http://www.mdpi.com/1420-3049/22/2/153N-(benzothiazol-2-yl)-4-chlorobenzenesulphonamideneodymium(III) and thallium(III) complexesantibacterial activity |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Lawrence Nnamdi Obasi Uchechukwu Susan Oruma Ibrahim Abdulrazak Al-Swaidan Ponnadurai Ramasami Chigozie Julius Ezeorah Alfred Ezinna Ochonogor |
spellingShingle |
Lawrence Nnamdi Obasi Uchechukwu Susan Oruma Ibrahim Abdulrazak Al-Swaidan Ponnadurai Ramasami Chigozie Julius Ezeorah Alfred Ezinna Ochonogor Synthesis, Characterization and Antibacterial Studies of N-(Benzothiazol-2-yl)-4-chlorobenzenesulphonamide and Its Neodymium(III) and Thallium(III) Complexes Molecules N-(benzothiazol-2-yl)-4-chlorobenzenesulphonamide neodymium(III) and thallium(III) complexes antibacterial activity |
author_facet |
Lawrence Nnamdi Obasi Uchechukwu Susan Oruma Ibrahim Abdulrazak Al-Swaidan Ponnadurai Ramasami Chigozie Julius Ezeorah Alfred Ezinna Ochonogor |
author_sort |
Lawrence Nnamdi Obasi |
title |
Synthesis, Characterization and Antibacterial Studies of N-(Benzothiazol-2-yl)-4-chlorobenzenesulphonamide and Its Neodymium(III) and Thallium(III) Complexes |
title_short |
Synthesis, Characterization and Antibacterial Studies of N-(Benzothiazol-2-yl)-4-chlorobenzenesulphonamide and Its Neodymium(III) and Thallium(III) Complexes |
title_full |
Synthesis, Characterization and Antibacterial Studies of N-(Benzothiazol-2-yl)-4-chlorobenzenesulphonamide and Its Neodymium(III) and Thallium(III) Complexes |
title_fullStr |
Synthesis, Characterization and Antibacterial Studies of N-(Benzothiazol-2-yl)-4-chlorobenzenesulphonamide and Its Neodymium(III) and Thallium(III) Complexes |
title_full_unstemmed |
Synthesis, Characterization and Antibacterial Studies of N-(Benzothiazol-2-yl)-4-chlorobenzenesulphonamide and Its Neodymium(III) and Thallium(III) Complexes |
title_sort |
synthesis, characterization and antibacterial studies of n-(benzothiazol-2-yl)-4-chlorobenzenesulphonamide and its neodymium(iii) and thallium(iii) complexes |
publisher |
MDPI AG |
series |
Molecules |
issn |
1420-3049 |
publishDate |
2017-02-01 |
description |
N-(Benzothiazol-2-yl)-4-chlorobenzenesulphonamide (NBTCS) was synthesized by condensation reaction of 4-chlorobenzenesulphonyl chloride and 2-aminobenzothiazole in acetone under reflux. Neodymium(III) and thallium(III) complexes of the ligand were also synthesized. Both ligand and metal complexes were characterized using UV-Vis, IR, 1H- and 13C-NMR spectroscopies, elemental analysis and molar conductance measurement. IR studies revealed that the ligand is tridentate and coordinates to the metal ions through nitrogen and oxygen atoms of the sulphonamide group and nitrogen atom attached to benzothiazole ring. The neodymium(III) complex displays a coordination number of eight while thallium(III) complex displays a coordination number of six. The ligand and its complexes were screened in vitro for their antibacterial activities against Escherichia coli strains (E. coli 6 and E. coli 13), Proteus species, Staphylococcus aureus and Pseudomonas aeruginosa using the agar well diffusion technique. The synthesized compounds were found to be more active against the microorganisms screened relative to ciprofloxacin, gentamicin and co-trimoxazole. |
topic |
N-(benzothiazol-2-yl)-4-chlorobenzenesulphonamide neodymium(III) and thallium(III) complexes antibacterial activity |
url |
http://www.mdpi.com/1420-3049/22/2/153 |
work_keys_str_mv |
AT lawrencennamdiobasi synthesischaracterizationandantibacterialstudiesofnbenzothiazol2yl4chlorobenzenesulphonamideanditsneodymiumiiiandthalliumiiicomplexes AT uchechukwususanoruma synthesischaracterizationandantibacterialstudiesofnbenzothiazol2yl4chlorobenzenesulphonamideanditsneodymiumiiiandthalliumiiicomplexes AT ibrahimabdulrazakalswaidan synthesischaracterizationandantibacterialstudiesofnbenzothiazol2yl4chlorobenzenesulphonamideanditsneodymiumiiiandthalliumiiicomplexes AT ponnadurairamasami synthesischaracterizationandantibacterialstudiesofnbenzothiazol2yl4chlorobenzenesulphonamideanditsneodymiumiiiandthalliumiiicomplexes AT chigoziejuliusezeorah synthesischaracterizationandantibacterialstudiesofnbenzothiazol2yl4chlorobenzenesulphonamideanditsneodymiumiiiandthalliumiiicomplexes AT alfredezinnaochonogor synthesischaracterizationandantibacterialstudiesofnbenzothiazol2yl4chlorobenzenesulphonamideanditsneodymiumiiiandthalliumiiicomplexes |
_version_ |
1725926470785695744 |