Fibrillary glomerulonephritis in a human immunodeficiency virus-positive, hepatitis C-negative Indian patient: Expanding the profile of renal involvement in human immunodeficiency virus infection
Highly active anti retroviral therapy (HAART) has dramatically improved life expectancy of human immunodeficiency virus (HIV) infected patients, converting HIV infection into a chronic illness with associated changes in its attendant renal complications. The past two decades have witnessed a decreas...
Main Authors: | , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Wolters Kluwer Medknow Publications
2018-01-01
|
Series: | Indian Journal of Pathology and Microbiology |
Subjects: | |
Online Access: | http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2018;volume=61;issue=4;spage=610;epage=613;aulast=Matthai |
id |
doaj-0ceb8b9515c643d4a9ef227a692cd6b2 |
---|---|
record_format |
Article |
spelling |
doaj-0ceb8b9515c643d4a9ef227a692cd6b22020-11-24T22:03:18ZengWolters Kluwer Medknow PublicationsIndian Journal of Pathology and Microbiology0377-49292018-01-0161461061310.4103/IJPM.IJPM_52_18Fibrillary glomerulonephritis in a human immunodeficiency virus-positive, hepatitis C-negative Indian patient: Expanding the profile of renal involvement in human immunodeficiency virus infectionSmita Mary MatthaiAnna T ValsonNeelaveni DuhliPriscilla RupaliAnna B PulimoodSantosh VarugheseHighly active anti retroviral therapy (HAART) has dramatically improved life expectancy of human immunodeficiency virus (HIV) infected patients, converting HIV infection into a chronic illness with associated changes in its attendant renal complications. The past two decades have witnessed a decrease in the prevalence of HIV associated nephropathy (HIVAN), traditionally considered to be the hall mark of renal involvement in HIV infection. Simultaneously a host of other glomerular and tubulo-interstitial diseases have emerged, expanding the spectrum of HIV associated renal diseases, predominant among which is HIV associated immune complex mediated kidney diseases (HIVICK). Of the diverse glomerular diseases constituting HIVICK, fibrillary glomerulonephritis (FGN) remains a rarity, with only two existing reports to date, confined to patients co-infected with Hepatitis C virus (HCV). The pathogenetic role of HIV in these patients remains under a cloud because of previously well established association of HCV infection and FGN. We report a case of FGN in a HIV seropositive, HCV negative Indian patient, highlighting the diagnostic electron microscopy (EM) findings of FGN and strengthening the causal association of HIV with FGN. In view of increasing heterogeneity of renal complications in HIV infection, the diagnostic utility of a comprehensive renal biopsy evaluation inclusive of EM is emphasized for appropriate selection of treatment modalities.http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2018;volume=61;issue=4;spage=610;epage=613;aulast=MatthaiFibrillary glomerulonephritisHIV associated immune complex mediated kidney diseaseHIV associated nephropathyHIV associated renal diseaseHuman Immunodeficiency virus infection |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Smita Mary Matthai Anna T Valson Neelaveni Duhli Priscilla Rupali Anna B Pulimood Santosh Varughese |
spellingShingle |
Smita Mary Matthai Anna T Valson Neelaveni Duhli Priscilla Rupali Anna B Pulimood Santosh Varughese Fibrillary glomerulonephritis in a human immunodeficiency virus-positive, hepatitis C-negative Indian patient: Expanding the profile of renal involvement in human immunodeficiency virus infection Indian Journal of Pathology and Microbiology Fibrillary glomerulonephritis HIV associated immune complex mediated kidney disease HIV associated nephropathy HIV associated renal disease Human Immunodeficiency virus infection |
author_facet |
Smita Mary Matthai Anna T Valson Neelaveni Duhli Priscilla Rupali Anna B Pulimood Santosh Varughese |
author_sort |
Smita Mary Matthai |
title |
Fibrillary glomerulonephritis in a human immunodeficiency virus-positive, hepatitis C-negative Indian patient: Expanding the profile of renal involvement in human immunodeficiency virus infection |
title_short |
Fibrillary glomerulonephritis in a human immunodeficiency virus-positive, hepatitis C-negative Indian patient: Expanding the profile of renal involvement in human immunodeficiency virus infection |
title_full |
Fibrillary glomerulonephritis in a human immunodeficiency virus-positive, hepatitis C-negative Indian patient: Expanding the profile of renal involvement in human immunodeficiency virus infection |
title_fullStr |
Fibrillary glomerulonephritis in a human immunodeficiency virus-positive, hepatitis C-negative Indian patient: Expanding the profile of renal involvement in human immunodeficiency virus infection |
title_full_unstemmed |
Fibrillary glomerulonephritis in a human immunodeficiency virus-positive, hepatitis C-negative Indian patient: Expanding the profile of renal involvement in human immunodeficiency virus infection |
title_sort |
fibrillary glomerulonephritis in a human immunodeficiency virus-positive, hepatitis c-negative indian patient: expanding the profile of renal involvement in human immunodeficiency virus infection |
publisher |
Wolters Kluwer Medknow Publications |
series |
Indian Journal of Pathology and Microbiology |
issn |
0377-4929 |
publishDate |
2018-01-01 |
description |
Highly active anti retroviral therapy (HAART) has dramatically improved life expectancy of human immunodeficiency virus (HIV) infected patients, converting HIV infection into a chronic illness with associated changes in its attendant renal complications. The past two decades have witnessed a decrease in the prevalence of HIV associated nephropathy (HIVAN), traditionally considered to be the hall mark of renal involvement in HIV infection. Simultaneously a host of other glomerular and tubulo-interstitial diseases have emerged, expanding the spectrum of HIV associated renal diseases, predominant among which is HIV associated immune complex mediated kidney diseases (HIVICK). Of the diverse glomerular diseases constituting HIVICK, fibrillary glomerulonephritis (FGN) remains a rarity, with only two existing reports to date, confined to patients co-infected with Hepatitis C virus (HCV). The pathogenetic role of HIV in these patients remains under a cloud because of previously well established association of HCV infection and FGN. We report a case of FGN in a HIV seropositive, HCV negative Indian patient, highlighting the diagnostic electron microscopy (EM) findings of FGN and strengthening the causal association of HIV with FGN. In view of increasing heterogeneity of renal complications in HIV infection, the diagnostic utility of a comprehensive renal biopsy evaluation inclusive of EM is emphasized for appropriate selection of treatment modalities. |
topic |
Fibrillary glomerulonephritis HIV associated immune complex mediated kidney disease HIV associated nephropathy HIV associated renal disease Human Immunodeficiency virus infection |
url |
http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2018;volume=61;issue=4;spage=610;epage=613;aulast=Matthai |
work_keys_str_mv |
AT smitamarymatthai fibrillaryglomerulonephritisinahumanimmunodeficiencyviruspositivehepatitiscnegativeindianpatientexpandingtheprofileofrenalinvolvementinhumanimmunodeficiencyvirusinfection AT annatvalson fibrillaryglomerulonephritisinahumanimmunodeficiencyviruspositivehepatitiscnegativeindianpatientexpandingtheprofileofrenalinvolvementinhumanimmunodeficiencyvirusinfection AT neelaveniduhli fibrillaryglomerulonephritisinahumanimmunodeficiencyviruspositivehepatitiscnegativeindianpatientexpandingtheprofileofrenalinvolvementinhumanimmunodeficiencyvirusinfection AT priscillarupali fibrillaryglomerulonephritisinahumanimmunodeficiencyviruspositivehepatitiscnegativeindianpatientexpandingtheprofileofrenalinvolvementinhumanimmunodeficiencyvirusinfection AT annabpulimood fibrillaryglomerulonephritisinahumanimmunodeficiencyviruspositivehepatitiscnegativeindianpatientexpandingtheprofileofrenalinvolvementinhumanimmunodeficiencyvirusinfection AT santoshvarughese fibrillaryglomerulonephritisinahumanimmunodeficiencyviruspositivehepatitiscnegativeindianpatientexpandingtheprofileofrenalinvolvementinhumanimmunodeficiencyvirusinfection |
_version_ |
1725832282210566144 |