Active Forces of Myosin Motors May Control Endovesiculation of Red Blood Cells

Active Forces of Myosin Motors May Control Endovesiculation of Red Blood Cells

By using Monte Carlo (MC) simulations, we have shown that the active forces generated by (NMIIA) motor domains bound to F-actin may partially control the endovesiculation of the red blood cell (RBC) membrane. The myosin generated active forces favor pancake-like (torocyte) RBC endovesicles with a la...

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Main Authors: Samo Penič, Miha Fošnarič, Luka Mesarec, Aleš Iglič, Veronika Kralj-Iglič
Format: Article
Language:English
Published: Slovenian Chemical Society 2020-06-01
Series:Acta Chimica Slovenica
Subjects:
myosin generated active forces
monte carlo simulations
endovesiclulation
intrinsic curvature
red blood cell
Online Access:https://journals.matheo.si/index.php/ACSi/article/view/5863
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spelling doaj-0d09ee8eef334c83a720120e91664b0e2020-11-25T02:58:36ZengSlovenian Chemical SocietyActa Chimica Slovenica1318-02071580-31552020-06-0167267468110.17344/acsi.2020.5863824Active Forces of Myosin Motors May Control Endovesiculation of Red Blood CellsSamo Penič0Miha Fošnarič1Luka Mesarec2Aleš Iglič3Veronika Kralj-Iglič4Faculty of Electrical Engineering, University of LjubljanaFaculty of Health Sciences, University of LjubljanaFaculty of Electrical Engineering, University of LjubljanaFaculty of Electrical Engineering, University of Ljubljana Faculty of Medicine, University of LjubljanaFaculty of Health Sciences, University of Ljubljana Faculty of Electrical Engineering, University of LjubljanaBy using Monte Carlo (MC) simulations, we have shown that the active forces generated by (NMIIA) motor domains bound to F-actin may partially control the endovesiculation of the red blood cell (RBC) membrane. The myosin generated active forces favor pancake-like (torocyte) RBC endovesicles with a large flat central membrane region and a bulby periphery. We suggest that the myosin generated active forces acting on the RBC membrane in the direction perpendicular to the membrane surface towards the interior of the RBC may influence also other RBC shape transformations and the stability of different types of RBC shapes and should be therefore considered in the future theoretical studies of the RBC vesiculation and shape transformations.https://journals.matheo.si/index.php/ACSi/article/view/5863myosin generated active forcesmonte carlo simulationsendovesiclulationintrinsic curvaturered blood cell
collection DOAJ
language English
format Article
sources DOAJ
author Samo Penič
Miha Fošnarič
Luka Mesarec
Aleš Iglič
Veronika Kralj-Iglič
spellingShingle Samo Penič
Miha Fošnarič
Luka Mesarec
Aleš Iglič
Veronika Kralj-Iglič
Active Forces of Myosin Motors May Control Endovesiculation of Red Blood Cells
Acta Chimica Slovenica
myosin generated active forces
monte carlo simulations
endovesiclulation
intrinsic curvature
red blood cell
author_facet Samo Penič
Miha Fošnarič
Luka Mesarec
Aleš Iglič
Veronika Kralj-Iglič
author_sort Samo Penič
title Active Forces of Myosin Motors May Control Endovesiculation of Red Blood Cells
title_short Active Forces of Myosin Motors May Control Endovesiculation of Red Blood Cells
title_full Active Forces of Myosin Motors May Control Endovesiculation of Red Blood Cells
title_fullStr Active Forces of Myosin Motors May Control Endovesiculation of Red Blood Cells
title_full_unstemmed Active Forces of Myosin Motors May Control Endovesiculation of Red Blood Cells
title_sort active forces of myosin motors may control endovesiculation of red blood cells
publisher Slovenian Chemical Society
series Acta Chimica Slovenica
issn 1318-0207
1580-3155
publishDate 2020-06-01
description By using Monte Carlo (MC) simulations, we have shown that the active forces generated by (NMIIA) motor domains bound to F-actin may partially control the endovesiculation of the red blood cell (RBC) membrane. The myosin generated active forces favor pancake-like (torocyte) RBC endovesicles with a large flat central membrane region and a bulby periphery. We suggest that the myosin generated active forces acting on the RBC membrane in the direction perpendicular to the membrane surface towards the interior of the RBC may influence also other RBC shape transformations and the stability of different types of RBC shapes and should be therefore considered in the future theoretical studies of the RBC vesiculation and shape transformations.
topic myosin generated active forces
monte carlo simulations
endovesiclulation
intrinsic curvature
red blood cell
url https://journals.matheo.si/index.php/ACSi/article/view/5863
work_keys_str_mv AT samopenic activeforcesofmyosinmotorsmaycontrolendovesiculationofredbloodcells
AT mihafosnaric activeforcesofmyosinmotorsmaycontrolendovesiculationofredbloodcells
AT lukamesarec activeforcesofmyosinmotorsmaycontrolendovesiculationofredbloodcells
AT alesiglic activeforcesofmyosinmotorsmaycontrolendovesiculationofredbloodcells
AT veronikakraljiglic activeforcesofmyosinmotorsmaycontrolendovesiculationofredbloodcells
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