Spinal cord injury causes chronic bone marrow failure

Spinal cord injury (SCI) often leads to immune dysfunction, but mechanistic insights are still lacking. Here the authors show that SCI alters chemokine signaling and induces long, persisting defects in hematopoietic stem and progenitor cell migration, thereby entrapping them in the bone marrow and d...

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Main Authors:	Randall S. Carpenter, Jessica M. Marbourg, Faith H. Brennan, Katherine A. Mifflin, Jodie C. E. Hall, Roselyn R. Jiang, Xiaokui M. Mo, Malith Karunasiri, Matthew H. Burke, Adrienne M. Dorrance, Phillip G. Popovich
Format:	Article
Language:	English
Published:	Nature Publishing Group 2020-07-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-020-17564-z

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spelling	doaj-0d1de6f876b2431485cb553f43443b202021-07-25T11:39:43ZengNature Publishing GroupNature Communications2041-17232020-07-0111111310.1038/s41467-020-17564-zSpinal cord injury causes chronic bone marrow failureRandall S. Carpenter0Jessica M. Marbourg1Faith H. Brennan2Katherine A. Mifflin3Jodie C. E. Hall4Roselyn R. Jiang5Xiaokui M. Mo6Malith Karunasiri7Matthew H. Burke8Adrienne M. Dorrance9Phillip G. Popovich10Neuroscience Graduate Program, The Ohio State UniversityNeuroscience Graduate Program, The Ohio State UniversityDepartment of Neuroscience, The Ohio State UniversityDepartment of Neuroscience, The Ohio State UniversityDepartment of Neuroscience, The Ohio State UniversityDepartment of Neuroscience, The Ohio State UniversityCenter for Biostatistics and Bioinformatics, The Ohio State UniversityComprehensive Cancer Center, The Ohio State UniversityComprehensive Cancer Center, The Ohio State UniversityComprehensive Cancer Center, The Ohio State UniversityDepartment of Neuroscience, The Ohio State UniversitySpinal cord injury (SCI) often leads to immune dysfunction, but mechanistic insights are still lacking. Here the authors show that SCI alters chemokine signaling and induces long, persisting defects in hematopoietic stem and progenitor cell migration, thereby entrapping them in the bone marrow and disrupting peripheral immune homeostasis.https://doi.org/10.1038/s41467-020-17564-z
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Randall S. Carpenter Jessica M. Marbourg Faith H. Brennan Katherine A. Mifflin Jodie C. E. Hall Roselyn R. Jiang Xiaokui M. Mo Malith Karunasiri Matthew H. Burke Adrienne M. Dorrance Phillip G. Popovich
spellingShingle	Randall S. Carpenter Jessica M. Marbourg Faith H. Brennan Katherine A. Mifflin Jodie C. E. Hall Roselyn R. Jiang Xiaokui M. Mo Malith Karunasiri Matthew H. Burke Adrienne M. Dorrance Phillip G. Popovich Spinal cord injury causes chronic bone marrow failure Nature Communications
author_facet	Randall S. Carpenter Jessica M. Marbourg Faith H. Brennan Katherine A. Mifflin Jodie C. E. Hall Roselyn R. Jiang Xiaokui M. Mo Malith Karunasiri Matthew H. Burke Adrienne M. Dorrance Phillip G. Popovich
author_sort	Randall S. Carpenter
title	Spinal cord injury causes chronic bone marrow failure
title_short	Spinal cord injury causes chronic bone marrow failure
title_full	Spinal cord injury causes chronic bone marrow failure
title_fullStr	Spinal cord injury causes chronic bone marrow failure
title_full_unstemmed	Spinal cord injury causes chronic bone marrow failure
title_sort	spinal cord injury causes chronic bone marrow failure
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2020-07-01
description	Spinal cord injury (SCI) often leads to immune dysfunction, but mechanistic insights are still lacking. Here the authors show that SCI alters chemokine signaling and induces long, persisting defects in hematopoietic stem and progenitor cell migration, thereby entrapping them in the bone marrow and disrupting peripheral immune homeostasis.
url	https://doi.org/10.1038/s41467-020-17564-z
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Spinal cord injury causes chronic bone marrow failure

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