A Magnetic and pH-Sensitive Composite Nanoparticle for Drug Delivery
Mild acid response nanocarriers have been intensively attracted interest in the field of drug delivery on the account of the responsive property to abnormal physiological environment as well as the original property to normal physiological environment. However, the drug delivery system lacks capacit...
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doaj-0d4633ac1cd147a889f71887e577279b2020-11-25T00:09:17ZengHindawi LimitedJournal of Nanomaterials1687-41101687-41292018-01-01201810.1155/2018/15063421506342A Magnetic and pH-Sensitive Composite Nanoparticle for Drug DeliveryXin Wang0Ziyu Gao1Long Zhang2Huiming Wang3Xiaohong Hu4School of Material Engineering, Jinling Institute of Technology, Nanjing 211169, ChinaSchool of Material Engineering, Jinling Institute of Technology, Nanjing 211169, ChinaSchool of Material Engineering, Jinling Institute of Technology, Nanjing 211169, ChinaSchool of Material Engineering, Jinling Institute of Technology, Nanjing 211169, ChinaSchool of Material Engineering, Jinling Institute of Technology, Nanjing 211169, ChinaMild acid response nanocarriers have been intensively attracted interest in the field of drug delivery on the account of the responsive property to abnormal physiological environment as well as the original property to normal physiological environment. However, the drug delivery system lacks capacity of precise localization to abnormal tissue or targeted cells. Therefore, a magnetic and pH-sensitive composite nanoparticle was designed and prepared by double water-in-oil-in-water (W/O/W) emulsion using acetylated β-cyclodextrin (Ac-β-CD) as a dominant material to realize the pH response and Fe3O4 as a component to realize magnetic response. The surface chemical characteristic was characterized by Fourier-transformed infrared spectroscopy (FTIR) using pure Ac-β-CD nanoparticle as a control and exhibits the typical chemical characteristic of Ac-β-CD. Furthermore, the structural information was tracked by X-ray diffraction (XRD) and thermogravimetric analysis (TG). It was found that composite nanoparticle possessed structural characteristic of both Ac-β-CD and Fe3O4. Composite nanoparticle exhibited sphere and two-phase morphology with the diameter of about 200–250 nm depending on their detection method and zeta potential of −12 to −14 mV. More importantly, irreversible pH response property and reversible magnetic responsive properties either in neutral environment or in mild acid environment for the composite nanoparticle were confirmed in the research. Finally, drug loading and release behavior were investigated through preliminary in vitro evaluation.http://dx.doi.org/10.1155/2018/1506342 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Xin Wang Ziyu Gao Long Zhang Huiming Wang Xiaohong Hu |
spellingShingle |
Xin Wang Ziyu Gao Long Zhang Huiming Wang Xiaohong Hu A Magnetic and pH-Sensitive Composite Nanoparticle for Drug Delivery Journal of Nanomaterials |
author_facet |
Xin Wang Ziyu Gao Long Zhang Huiming Wang Xiaohong Hu |
author_sort |
Xin Wang |
title |
A Magnetic and pH-Sensitive Composite Nanoparticle for Drug Delivery |
title_short |
A Magnetic and pH-Sensitive Composite Nanoparticle for Drug Delivery |
title_full |
A Magnetic and pH-Sensitive Composite Nanoparticle for Drug Delivery |
title_fullStr |
A Magnetic and pH-Sensitive Composite Nanoparticle for Drug Delivery |
title_full_unstemmed |
A Magnetic and pH-Sensitive Composite Nanoparticle for Drug Delivery |
title_sort |
magnetic and ph-sensitive composite nanoparticle for drug delivery |
publisher |
Hindawi Limited |
series |
Journal of Nanomaterials |
issn |
1687-4110 1687-4129 |
publishDate |
2018-01-01 |
description |
Mild acid response nanocarriers have been intensively attracted interest in the field of drug delivery on the account of the responsive property to abnormal physiological environment as well as the original property to normal physiological environment. However, the drug delivery system lacks capacity of precise localization to abnormal tissue or targeted cells. Therefore, a magnetic and pH-sensitive composite nanoparticle was designed and prepared by double water-in-oil-in-water (W/O/W) emulsion using acetylated β-cyclodextrin (Ac-β-CD) as a dominant material to realize the pH response and Fe3O4 as a component to realize magnetic response. The surface chemical characteristic was characterized by Fourier-transformed infrared spectroscopy (FTIR) using pure Ac-β-CD nanoparticle as a control and exhibits the typical chemical characteristic of Ac-β-CD. Furthermore, the structural information was tracked by X-ray diffraction (XRD) and thermogravimetric analysis (TG). It was found that composite nanoparticle possessed structural characteristic of both Ac-β-CD and Fe3O4. Composite nanoparticle exhibited sphere and two-phase morphology with the diameter of about 200–250 nm depending on their detection method and zeta potential of −12 to −14 mV. More importantly, irreversible pH response property and reversible magnetic responsive properties either in neutral environment or in mild acid environment for the composite nanoparticle were confirmed in the research. Finally, drug loading and release behavior were investigated through preliminary in vitro evaluation. |
url |
http://dx.doi.org/10.1155/2018/1506342 |
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