Bacillus clausii for the Treatment of Acute Diarrhea in Children: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Acute diarrhea is a burdensome disease with potentially harmful consequences, especially in childhood. Despite its large use in clinical practice, the efficacy of the probiotic Bacillus clausii in treating acute childhood diarrhea remains unclear. Our objective was to systematically review the effic...
Main Authors: | , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2018-08-01
|
Series: | Nutrients |
Subjects: | |
Online Access: | http://www.mdpi.com/2072-6643/10/8/1074 |
id |
doaj-0d4bd2a3d49b43a3bf60686f9faf360e |
---|---|
record_format |
Article |
spelling |
doaj-0d4bd2a3d49b43a3bf60686f9faf360e2020-11-24T20:43:30ZengMDPI AGNutrients2072-66432018-08-01108107410.3390/nu10081074nu10081074Bacillus clausii for the Treatment of Acute Diarrhea in Children: A Systematic Review and Meta-Analysis of Randomized Controlled TrialsGianluca Ianiro0Gianenrico Rizzatti1Manuel Plomer2Loris Lopetuso3Franco Scaldaferri4Francesco Franceschi5Giovanni Cammarota6Antonio Gasbarrini7Fondazione Policlinico Universitario A. Gemelli IRCCS-Università Cattolica del Sacro Cuore, 00143 Roma, ItalyFondazione Policlinico Universitario A. Gemelli IRCCS-Università Cattolica del Sacro Cuore, 00143 Roma, ItalyMedical Affairs CHC Germany, Sanofi-Aventis Deutschland GmbH, Industriepark Höchst, D-65926 Frankfurt am Main, GermanyFondazione Policlinico Universitario A. Gemelli IRCCS-Università Cattolica del Sacro Cuore, 00143 Roma, ItalyFondazione Policlinico Universitario A. Gemelli IRCCS-Università Cattolica del Sacro Cuore, 00143 Roma, ItalyFondazione Policlinico Universitario A. Gemelli IRCCS-Università Cattolica del Sacro Cuore, 00143 Roma, ItalyFondazione Policlinico Universitario A. Gemelli IRCCS-Università Cattolica del Sacro Cuore, 00143 Roma, ItalyFondazione Policlinico Universitario A. Gemelli IRCCS-Università Cattolica del Sacro Cuore, 00143 Roma, ItalyAcute diarrhea is a burdensome disease with potentially harmful consequences, especially in childhood. Despite its large use in clinical practice, the efficacy of the probiotic Bacillus clausii in treating acute childhood diarrhea remains unclear. Our objective was to systematically review the efficacy of Bacillus clausii in the treatment of acute childhood diarrhea. The following electronic databases were systematically searched up to October 2017: MEDLINE (via PubMed/OVID), EMBASE (via OVID), Cochrane Central Database of Controlled Trials (via CENTRAL), Google Scholar, and ClinicalTrials.gov. Only randomized controlled trials were included. The overall effect for the meta-analysis was derived by using a random effects model. Six randomized controlled trials (1298 patients) met the eligibility criteria. Data arising from pooled analysis showed that Bacillus clausii significantly reduced the duration of diarrhea (mean difference = −9.12 h; 95% confidence interval [CI]: −16.49 to −1.75, p = 0.015), and the duration of hospitalization (mean difference = −0.85 days; 95% CI: −1.56 to −0.15, p = 0.017), compared with control. There was a trend of decreasing stool frequency after Bacillus clausii administration compared with the control group (mean difference = −0.19 diarrheal motions; 95% CI: −0.43 to −0.06, p = 0.14). Bacillus clausii may represent an effective therapeutic option in acute childhood diarrhea, with a good safety profile.http://www.mdpi.com/2072-6643/10/8/1074acute diarrheachildrenBacillus clausiiefficacyrandomized controlled trials |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Gianluca Ianiro Gianenrico Rizzatti Manuel Plomer Loris Lopetuso Franco Scaldaferri Francesco Franceschi Giovanni Cammarota Antonio Gasbarrini |
spellingShingle |
Gianluca Ianiro Gianenrico Rizzatti Manuel Plomer Loris Lopetuso Franco Scaldaferri Francesco Franceschi Giovanni Cammarota Antonio Gasbarrini Bacillus clausii for the Treatment of Acute Diarrhea in Children: A Systematic Review and Meta-Analysis of Randomized Controlled Trials Nutrients acute diarrhea children Bacillus clausii efficacy randomized controlled trials |
author_facet |
Gianluca Ianiro Gianenrico Rizzatti Manuel Plomer Loris Lopetuso Franco Scaldaferri Francesco Franceschi Giovanni Cammarota Antonio Gasbarrini |
author_sort |
Gianluca Ianiro |
title |
Bacillus clausii for the Treatment of Acute Diarrhea in Children: A Systematic Review and Meta-Analysis of Randomized Controlled Trials |
title_short |
Bacillus clausii for the Treatment of Acute Diarrhea in Children: A Systematic Review and Meta-Analysis of Randomized Controlled Trials |
title_full |
Bacillus clausii for the Treatment of Acute Diarrhea in Children: A Systematic Review and Meta-Analysis of Randomized Controlled Trials |
title_fullStr |
Bacillus clausii for the Treatment of Acute Diarrhea in Children: A Systematic Review and Meta-Analysis of Randomized Controlled Trials |
title_full_unstemmed |
Bacillus clausii for the Treatment of Acute Diarrhea in Children: A Systematic Review and Meta-Analysis of Randomized Controlled Trials |
title_sort |
bacillus clausii for the treatment of acute diarrhea in children: a systematic review and meta-analysis of randomized controlled trials |
publisher |
MDPI AG |
series |
Nutrients |
issn |
2072-6643 |
publishDate |
2018-08-01 |
description |
Acute diarrhea is a burdensome disease with potentially harmful consequences, especially in childhood. Despite its large use in clinical practice, the efficacy of the probiotic Bacillus clausii in treating acute childhood diarrhea remains unclear. Our objective was to systematically review the efficacy of Bacillus clausii in the treatment of acute childhood diarrhea. The following electronic databases were systematically searched up to October 2017: MEDLINE (via PubMed/OVID), EMBASE (via OVID), Cochrane Central Database of Controlled Trials (via CENTRAL), Google Scholar, and ClinicalTrials.gov. Only randomized controlled trials were included. The overall effect for the meta-analysis was derived by using a random effects model. Six randomized controlled trials (1298 patients) met the eligibility criteria. Data arising from pooled analysis showed that Bacillus clausii significantly reduced the duration of diarrhea (mean difference = −9.12 h; 95% confidence interval [CI]: −16.49 to −1.75, p = 0.015), and the duration of hospitalization (mean difference = −0.85 days; 95% CI: −1.56 to −0.15, p = 0.017), compared with control. There was a trend of decreasing stool frequency after Bacillus clausii administration compared with the control group (mean difference = −0.19 diarrheal motions; 95% CI: −0.43 to −0.06, p = 0.14). Bacillus clausii may represent an effective therapeutic option in acute childhood diarrhea, with a good safety profile. |
topic |
acute diarrhea children Bacillus clausii efficacy randomized controlled trials |
url |
http://www.mdpi.com/2072-6643/10/8/1074 |
work_keys_str_mv |
AT gianlucaianiro bacillusclausiiforthetreatmentofacutediarrheainchildrenasystematicreviewandmetaanalysisofrandomizedcontrolledtrials AT gianenricorizzatti bacillusclausiiforthetreatmentofacutediarrheainchildrenasystematicreviewandmetaanalysisofrandomizedcontrolledtrials AT manuelplomer bacillusclausiiforthetreatmentofacutediarrheainchildrenasystematicreviewandmetaanalysisofrandomizedcontrolledtrials AT lorislopetuso bacillusclausiiforthetreatmentofacutediarrheainchildrenasystematicreviewandmetaanalysisofrandomizedcontrolledtrials AT francoscaldaferri bacillusclausiiforthetreatmentofacutediarrheainchildrenasystematicreviewandmetaanalysisofrandomizedcontrolledtrials AT francescofranceschi bacillusclausiiforthetreatmentofacutediarrheainchildrenasystematicreviewandmetaanalysisofrandomizedcontrolledtrials AT giovannicammarota bacillusclausiiforthetreatmentofacutediarrheainchildrenasystematicreviewandmetaanalysisofrandomizedcontrolledtrials AT antoniogasbarrini bacillusclausiiforthetreatmentofacutediarrheainchildrenasystematicreviewandmetaanalysisofrandomizedcontrolledtrials |
_version_ |
1716819676879650816 |