Environmental Optimization Enables Maintenance of Quiescent Hematopoietic Stem Cells Ex Vivo
Summary: Hematopoietic stem cells (HSCs) maintain lifelong hematopoiesis by remaining quiescent in the bone marrow niche. Recapitulation of a quiescent state in culture has not been achieved, as cells rapidly proliferate and differentiate in vitro. After exhaustive analysis of different environmenta...
Main Authors: | Hiroshi Kobayashi, Takayuki Morikawa, Ayumi Okinaga, Fumie Hamano, Tomomi Hashidate-Yoshida, Shintaro Watanuki, Daisuke Hishikawa, Hideo Shindou, Fumio Arai, Yasuaki Kabe, Makoto Suematsu, Takao Shimizu, Keiyo Takubo |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2019-07-01
|
Series: | Cell Reports |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124719307661 |
Similar Items
-
Protocol for the Maintenance of Quiescent Murine Hematopoietic Stem Cells
by: Hiroshi Kobayashi, et al.
Published: (2020-09-01) -
Diversity and function of membrane glycerophospholipids generated by the remodeling pathway in mammalian cells
by: Daisuke Hishikawa, et al.
Published: (2014-05-01) -
Use of Imaging Techniques to Illuminate Dynamics of Hematopoietic Stem Cells and Their Niches
by: Takayuki Morikawa, et al.
Published: (2017-06-01) -
Quiescence of adult oligodendrocyte precursor cells requires thyroid hormone and hypoxia to activate Runx1
by: Yasuhito Tokumoto, et al.
Published: (2017-04-01) -
Hepatic Levels of DHA-Containing Phospholipids Instruct SREBP1-Mediated Synthesis and Systemic Delivery of Polyunsaturated Fatty Acids
by: Daisuke Hishikawa, et al.
Published: (2020-09-01)