Immune regulation during chronic visceral leishmaniasis.

Immune regulation during chronic visceral leishmaniasis.

Visceral leishmaniasis is a chronic parasitic disease associated with severe immune dysfunction. Treatment options are limited to relatively toxic drugs, and there is no vaccine for humans available. Hence, there is an urgent need to better understand immune responses following infection with Leishm...

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Main Authors: Rebecca J Faleiro, Rajiv Kumar, Louise M Hafner, Christian R Engwerda
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-07-01
Series:PLoS Neglected Tropical Diseases
Online Access:http://europepmc.org/articles/PMC4091888?pdf=render
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spelling doaj-0d5dc2a5687544f6ba10ae24288b0cfa2020-11-25T02:42:37ZengPublic Library of Science (PLoS)PLoS Neglected Tropical Diseases1935-27271935-27352014-07-0187e291410.1371/journal.pntd.0002914Immune regulation during chronic visceral leishmaniasis.Rebecca J FaleiroRajiv KumarLouise M HafnerChristian R EngwerdaVisceral leishmaniasis is a chronic parasitic disease associated with severe immune dysfunction. Treatment options are limited to relatively toxic drugs, and there is no vaccine for humans available. Hence, there is an urgent need to better understand immune responses following infection with Leishmania species by studying animal models of disease and clinical samples from patients. Here, we review recent discoveries in these areas and highlight shortcomings in our knowledge that need to be addressed if better treatment options are to be developed and effective vaccines designed.http://europepmc.org/articles/PMC4091888?pdf=render
collection DOAJ
language English
format Article
sources DOAJ
author Rebecca J Faleiro
Rajiv Kumar
Louise M Hafner
Christian R Engwerda
spellingShingle Rebecca J Faleiro
Rajiv Kumar
Louise M Hafner
Christian R Engwerda
Immune regulation during chronic visceral leishmaniasis.
PLoS Neglected Tropical Diseases
author_facet Rebecca J Faleiro
Rajiv Kumar
Louise M Hafner
Christian R Engwerda
author_sort Rebecca J Faleiro
title Immune regulation during chronic visceral leishmaniasis.
title_short Immune regulation during chronic visceral leishmaniasis.
title_full Immune regulation during chronic visceral leishmaniasis.
title_fullStr Immune regulation during chronic visceral leishmaniasis.
title_full_unstemmed Immune regulation during chronic visceral leishmaniasis.
title_sort immune regulation during chronic visceral leishmaniasis.
publisher Public Library of Science (PLoS)
series PLoS Neglected Tropical Diseases
issn 1935-2727
1935-2735
publishDate 2014-07-01
description Visceral leishmaniasis is a chronic parasitic disease associated with severe immune dysfunction. Treatment options are limited to relatively toxic drugs, and there is no vaccine for humans available. Hence, there is an urgent need to better understand immune responses following infection with Leishmania species by studying animal models of disease and clinical samples from patients. Here, we review recent discoveries in these areas and highlight shortcomings in our knowledge that need to be addressed if better treatment options are to be developed and effective vaccines designed.
url http://europepmc.org/articles/PMC4091888?pdf=render
work_keys_str_mv AT rebeccajfaleiro immuneregulationduringchronicvisceralleishmaniasis
AT rajivkumar immuneregulationduringchronicvisceralleishmaniasis
AT louisemhafner immuneregulationduringchronicvisceralleishmaniasis
AT christianrengwerda immuneregulationduringchronicvisceralleishmaniasis
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