A mixed‐methods study of cyclin‐dependent kinase 4 and 6 inhibitor symptom burden and quality of life among metastatic breast cancer patients and providers
Abstract Background Cyclin‐dependent kinase 4 and 6 (CDK4/6) inhibitor targeted therapies dramatically improve survival outcomes for metastatic breast cancer (MBC), but they are associated with significant symptom burden that can impact patients’ health‐related quality of life (HRQOL) and treatment...
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doaj-0d7b4bc3a39f41bfb36711188b3568922021-07-20T08:11:37ZengWileyCancer Medicine2045-76342021-07-0110144823483110.1002/cam4.4055A mixed‐methods study of cyclin‐dependent kinase 4 and 6 inhibitor symptom burden and quality of life among metastatic breast cancer patients and providersLaura B. Oswald0Brandy Arredondo1Mika Kadono2Dinorah Martinez‐Tyson3Cathy D. Meade4Frank Penedo5Michael H. Antoni6Hatem Soliman7Ricardo L. B. Costa8Heather S. L. Jim9Health Outcomes and Behavior ProgramMoffitt Cancer Center Tampa FL USAParticipant Research, Interventions, and Measurement Core Moffitt Cancer Center Tampa FL USAInstitute for Health EquityAltaMed Health Services Los Angeles CA USACollege of Public Health University of South Florida Tampa FL USAHealth Outcomes and Behavior ProgramMoffitt Cancer Center Tampa FL USADepartment of Psychology University of Miami Coral Gables FL USADepartment of Psychology University of Miami Coral Gables FL USABreast Oncology Program Moffitt Cancer Center Tampa FL USABreast Oncology Program Moffitt Cancer Center Tampa FL USAHealth Outcomes and Behavior ProgramMoffitt Cancer Center Tampa FL USAAbstract Background Cyclin‐dependent kinase 4 and 6 (CDK4/6) inhibitor targeted therapies dramatically improve survival outcomes for metastatic breast cancer (MBC), but they are associated with significant symptom burden that can impact patients’ health‐related quality of life (HRQOL) and treatment outcomes. This study is the first to describe CDK4/6 inhibitor symptoms from the lived perspectives of MBC patients taking CDK4/6 inhibitors and healthcare providers involved in MBC care. This study also explored patients’ symptom management and HRQOL concerns, and gathered feedback about developing supportive interventions for MBC. Methods MBC patients taking CDK4/6 inhibitors (N = 20) and MBC healthcare providers (N = 12) participated in semi‐structured interviews that were analyzed for qualitative themes. MBC patients completed surveys about HRQOL, symptoms, and unmet needs. Results Patient and provider perceptions of CDK4/6 inhibitor symptoms did not align with patients perceiving symptoms as more burdensome. Patients reported that supportive resources (e.g., support groups, blogs) that are not specific to MBC do not adequately meet their needs. Patients and providers were enthusiastic about developing supportive interventions specifically for MBC and offered considerations for designing such interventions. Conclusions Findings highlight differences in perceptions of CDK4/6 inhibitor symptom burden between MBC patients and providers. Results will inform the development of supportive interventions to assist MBC patients in managing CDK4/6 inhibitor symptom burden and maintaining HRQOL. Such interventions could also improve treatment outcomes.https://doi.org/10.1002/cam4.4055breast neoplasmsneoplasm metastasispatient‐reported outcomes measurespsycho‐oncologyqualitative researchquality of life |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Laura B. Oswald Brandy Arredondo Mika Kadono Dinorah Martinez‐Tyson Cathy D. Meade Frank Penedo Michael H. Antoni Hatem Soliman Ricardo L. B. Costa Heather S. L. Jim |
spellingShingle |
Laura B. Oswald Brandy Arredondo Mika Kadono Dinorah Martinez‐Tyson Cathy D. Meade Frank Penedo Michael H. Antoni Hatem Soliman Ricardo L. B. Costa Heather S. L. Jim A mixed‐methods study of cyclin‐dependent kinase 4 and 6 inhibitor symptom burden and quality of life among metastatic breast cancer patients and providers Cancer Medicine breast neoplasms neoplasm metastasis patient‐reported outcomes measures psycho‐oncology qualitative research quality of life |
author_facet |
Laura B. Oswald Brandy Arredondo Mika Kadono Dinorah Martinez‐Tyson Cathy D. Meade Frank Penedo Michael H. Antoni Hatem Soliman Ricardo L. B. Costa Heather S. L. Jim |
author_sort |
Laura B. Oswald |
title |
A mixed‐methods study of cyclin‐dependent kinase 4 and 6 inhibitor symptom burden and quality of life among metastatic breast cancer patients and providers |
title_short |
A mixed‐methods study of cyclin‐dependent kinase 4 and 6 inhibitor symptom burden and quality of life among metastatic breast cancer patients and providers |
title_full |
A mixed‐methods study of cyclin‐dependent kinase 4 and 6 inhibitor symptom burden and quality of life among metastatic breast cancer patients and providers |
title_fullStr |
A mixed‐methods study of cyclin‐dependent kinase 4 and 6 inhibitor symptom burden and quality of life among metastatic breast cancer patients and providers |
title_full_unstemmed |
A mixed‐methods study of cyclin‐dependent kinase 4 and 6 inhibitor symptom burden and quality of life among metastatic breast cancer patients and providers |
title_sort |
mixed‐methods study of cyclin‐dependent kinase 4 and 6 inhibitor symptom burden and quality of life among metastatic breast cancer patients and providers |
publisher |
Wiley |
series |
Cancer Medicine |
issn |
2045-7634 |
publishDate |
2021-07-01 |
description |
Abstract Background Cyclin‐dependent kinase 4 and 6 (CDK4/6) inhibitor targeted therapies dramatically improve survival outcomes for metastatic breast cancer (MBC), but they are associated with significant symptom burden that can impact patients’ health‐related quality of life (HRQOL) and treatment outcomes. This study is the first to describe CDK4/6 inhibitor symptoms from the lived perspectives of MBC patients taking CDK4/6 inhibitors and healthcare providers involved in MBC care. This study also explored patients’ symptom management and HRQOL concerns, and gathered feedback about developing supportive interventions for MBC. Methods MBC patients taking CDK4/6 inhibitors (N = 20) and MBC healthcare providers (N = 12) participated in semi‐structured interviews that were analyzed for qualitative themes. MBC patients completed surveys about HRQOL, symptoms, and unmet needs. Results Patient and provider perceptions of CDK4/6 inhibitor symptoms did not align with patients perceiving symptoms as more burdensome. Patients reported that supportive resources (e.g., support groups, blogs) that are not specific to MBC do not adequately meet their needs. Patients and providers were enthusiastic about developing supportive interventions specifically for MBC and offered considerations for designing such interventions. Conclusions Findings highlight differences in perceptions of CDK4/6 inhibitor symptom burden between MBC patients and providers. Results will inform the development of supportive interventions to assist MBC patients in managing CDK4/6 inhibitor symptom burden and maintaining HRQOL. Such interventions could also improve treatment outcomes. |
topic |
breast neoplasms neoplasm metastasis patient‐reported outcomes measures psycho‐oncology qualitative research quality of life |
url |
https://doi.org/10.1002/cam4.4055 |
work_keys_str_mv |
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