Structure–function studies of ultrahigh molecular weight isoprenes provide key insights into their biosynthesis

Kajiura and Yoshizawa et al. identify three new prenyltransferases in the tree Eucommia ulmoides that synthesize exceptionally high molecular weight trans-1,4-polyisoprene (TPI). Through crystal structure and mutational analyses, they identify key residues required for TPI synthesis and reveal its f...

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Main Authors:	Hiroyuki Kajiura, Takuya Yoshizawa, Yuji Tokumoto, Nobuaki Suzuki, Shinya Takeno, Kanokwan Jumtee Takeno, Takuya Yamashita, Shun-ichi Tanaka, Yoshinobu Kaneko, Kazuhito Fujiyama, Hiroyoshi Matsumura, Yoshihisa Nakazawa
Format:	Article
Language:	English
Published:	Nature Publishing Group 2021-02-01
Series:	Communications Biology
Online Access:	https://doi.org/10.1038/s42003-021-01739-5

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spelling	doaj-0d8d4e20f5c54474bdd6cf4c60bfba982021-02-21T12:27:29ZengNature Publishing GroupCommunications Biology2399-36422021-02-014111310.1038/s42003-021-01739-5Structure–function studies of ultrahigh molecular weight isoprenes provide key insights into their biosynthesisHiroyuki Kajiura0Takuya Yoshizawa1Yuji Tokumoto2Nobuaki Suzuki3Shinya Takeno4Kanokwan Jumtee Takeno5Takuya Yamashita6Shun-ichi Tanaka7Yoshinobu Kaneko8Kazuhito Fujiyama9Hiroyoshi Matsumura10Yoshihisa Nakazawa11International Center for Biotechnology, Osaka UniversityDepartment of Biotechnology, College of Life Sciences, Ritsumeikan UniversityTechnical Research Institute, Hitachi Zosen CorporationTechnical Research Institute, Hitachi Zosen CorporationTechnical Research Institute, Hitachi Zosen CorporationTechnical Research Institute, Hitachi Zosen CorporationDepartment of Biotechnology, College of Life Sciences, Ritsumeikan UniversityDepartment of Biotechnology, College of Life Sciences, Ritsumeikan UniversityYeast Genetic Resources Lab, Graduate School of Engineering, Osaka UniversityInternational Center for Biotechnology, Osaka UniversityDepartment of Biotechnology, College of Life Sciences, Ritsumeikan UniversityTechnical Research Institute, Hitachi Zosen CorporationKajiura and Yoshizawa et al. identify three new prenyltransferases in the tree Eucommia ulmoides that synthesize exceptionally high molecular weight trans-1,4-polyisoprene (TPI). Through crystal structure and mutational analyses, they identify key residues required for TPI synthesis and reveal its functional importance in seed development.https://doi.org/10.1038/s42003-021-01739-5
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Hiroyuki Kajiura Takuya Yoshizawa Yuji Tokumoto Nobuaki Suzuki Shinya Takeno Kanokwan Jumtee Takeno Takuya Yamashita Shun-ichi Tanaka Yoshinobu Kaneko Kazuhito Fujiyama Hiroyoshi Matsumura Yoshihisa Nakazawa
spellingShingle	Hiroyuki Kajiura Takuya Yoshizawa Yuji Tokumoto Nobuaki Suzuki Shinya Takeno Kanokwan Jumtee Takeno Takuya Yamashita Shun-ichi Tanaka Yoshinobu Kaneko Kazuhito Fujiyama Hiroyoshi Matsumura Yoshihisa Nakazawa Structure–function studies of ultrahigh molecular weight isoprenes provide key insights into their biosynthesis Communications Biology
author_facet	Hiroyuki Kajiura Takuya Yoshizawa Yuji Tokumoto Nobuaki Suzuki Shinya Takeno Kanokwan Jumtee Takeno Takuya Yamashita Shun-ichi Tanaka Yoshinobu Kaneko Kazuhito Fujiyama Hiroyoshi Matsumura Yoshihisa Nakazawa
author_sort	Hiroyuki Kajiura
title	Structure–function studies of ultrahigh molecular weight isoprenes provide key insights into their biosynthesis
title_short	Structure–function studies of ultrahigh molecular weight isoprenes provide key insights into their biosynthesis
title_full	Structure–function studies of ultrahigh molecular weight isoprenes provide key insights into their biosynthesis
title_fullStr	Structure–function studies of ultrahigh molecular weight isoprenes provide key insights into their biosynthesis
title_full_unstemmed	Structure–function studies of ultrahigh molecular weight isoprenes provide key insights into their biosynthesis
title_sort	structure–function studies of ultrahigh molecular weight isoprenes provide key insights into their biosynthesis
publisher	Nature Publishing Group
series	Communications Biology
issn	2399-3642
publishDate	2021-02-01
description	Kajiura and Yoshizawa et al. identify three new prenyltransferases in the tree Eucommia ulmoides that synthesize exceptionally high molecular weight trans-1,4-polyisoprene (TPI). Through crystal structure and mutational analyses, they identify key residues required for TPI synthesis and reveal its functional importance in seed development.
url	https://doi.org/10.1038/s42003-021-01739-5
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Structure–function studies of ultrahigh molecular weight isoprenes provide key insights into their biosynthesis

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