Structure–function studies of ultrahigh molecular weight isoprenes provide key insights into their biosynthesis
Kajiura and Yoshizawa et al. identify three new prenyltransferases in the tree Eucommia ulmoides that synthesize exceptionally high molecular weight trans-1,4-polyisoprene (TPI). Through crystal structure and mutational analyses, they identify key residues required for TPI synthesis and reveal its f...
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2021-02-01
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Series: | Communications Biology |
Online Access: | https://doi.org/10.1038/s42003-021-01739-5 |
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doaj-0d8d4e20f5c54474bdd6cf4c60bfba982021-02-21T12:27:29ZengNature Publishing GroupCommunications Biology2399-36422021-02-014111310.1038/s42003-021-01739-5Structure–function studies of ultrahigh molecular weight isoprenes provide key insights into their biosynthesisHiroyuki Kajiura0Takuya Yoshizawa1Yuji Tokumoto2Nobuaki Suzuki3Shinya Takeno4Kanokwan Jumtee Takeno5Takuya Yamashita6Shun-ichi Tanaka7Yoshinobu Kaneko8Kazuhito Fujiyama9Hiroyoshi Matsumura10Yoshihisa Nakazawa11International Center for Biotechnology, Osaka UniversityDepartment of Biotechnology, College of Life Sciences, Ritsumeikan UniversityTechnical Research Institute, Hitachi Zosen CorporationTechnical Research Institute, Hitachi Zosen CorporationTechnical Research Institute, Hitachi Zosen CorporationTechnical Research Institute, Hitachi Zosen CorporationDepartment of Biotechnology, College of Life Sciences, Ritsumeikan UniversityDepartment of Biotechnology, College of Life Sciences, Ritsumeikan UniversityYeast Genetic Resources Lab, Graduate School of Engineering, Osaka UniversityInternational Center for Biotechnology, Osaka UniversityDepartment of Biotechnology, College of Life Sciences, Ritsumeikan UniversityTechnical Research Institute, Hitachi Zosen CorporationKajiura and Yoshizawa et al. identify three new prenyltransferases in the tree Eucommia ulmoides that synthesize exceptionally high molecular weight trans-1,4-polyisoprene (TPI). Through crystal structure and mutational analyses, they identify key residues required for TPI synthesis and reveal its functional importance in seed development.https://doi.org/10.1038/s42003-021-01739-5 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Hiroyuki Kajiura Takuya Yoshizawa Yuji Tokumoto Nobuaki Suzuki Shinya Takeno Kanokwan Jumtee Takeno Takuya Yamashita Shun-ichi Tanaka Yoshinobu Kaneko Kazuhito Fujiyama Hiroyoshi Matsumura Yoshihisa Nakazawa |
spellingShingle |
Hiroyuki Kajiura Takuya Yoshizawa Yuji Tokumoto Nobuaki Suzuki Shinya Takeno Kanokwan Jumtee Takeno Takuya Yamashita Shun-ichi Tanaka Yoshinobu Kaneko Kazuhito Fujiyama Hiroyoshi Matsumura Yoshihisa Nakazawa Structure–function studies of ultrahigh molecular weight isoprenes provide key insights into their biosynthesis Communications Biology |
author_facet |
Hiroyuki Kajiura Takuya Yoshizawa Yuji Tokumoto Nobuaki Suzuki Shinya Takeno Kanokwan Jumtee Takeno Takuya Yamashita Shun-ichi Tanaka Yoshinobu Kaneko Kazuhito Fujiyama Hiroyoshi Matsumura Yoshihisa Nakazawa |
author_sort |
Hiroyuki Kajiura |
title |
Structure–function studies of ultrahigh molecular weight isoprenes provide key insights into their biosynthesis |
title_short |
Structure–function studies of ultrahigh molecular weight isoprenes provide key insights into their biosynthesis |
title_full |
Structure–function studies of ultrahigh molecular weight isoprenes provide key insights into their biosynthesis |
title_fullStr |
Structure–function studies of ultrahigh molecular weight isoprenes provide key insights into their biosynthesis |
title_full_unstemmed |
Structure–function studies of ultrahigh molecular weight isoprenes provide key insights into their biosynthesis |
title_sort |
structure–function studies of ultrahigh molecular weight isoprenes provide key insights into their biosynthesis |
publisher |
Nature Publishing Group |
series |
Communications Biology |
issn |
2399-3642 |
publishDate |
2021-02-01 |
description |
Kajiura and Yoshizawa et al. identify three new prenyltransferases in the tree Eucommia ulmoides that synthesize exceptionally high molecular weight trans-1,4-polyisoprene (TPI). Through crystal structure and mutational analyses, they identify key residues required for TPI synthesis and reveal its functional importance in seed development. |
url |
https://doi.org/10.1038/s42003-021-01739-5 |
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