The First Word Recalled Measure – A Potential Addition to Clinical Exams
Characterizing episodic memory abilities is highly important in the diagnosis of Alzheimer's disease (AD) and mild cognitive impairment (MCI), and usually includes wordlist learning and recall tasks. Clinical evaluations typically focus on the number of words recalled, ignoring additional infor...
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doaj-0d937010acc44f1c91261e64da25ab422021-02-01T05:07:45ZengFrontiers Media S.A.Frontiers in Neurology1664-22952021-02-011210.3389/fneur.2021.561824561824The First Word Recalled Measure – A Potential Addition to Clinical ExamsIrit Shapira-Lichter0Irit Shapira-Lichter1Noga Oren2Anita Asvadurian3Rachel Ben-Hayun4Tali Fisher5Judith Aharon-Peretz6Amir Glik7Amir Glik8Functional MRI Center, Beilinson Hospital, Petach Tikva, IsraelSackler Faculty of Medicine, Tel Aviv University, Tel Aviv, IsraelFunctional MRI Center, Beilinson Hospital, Petach Tikva, IsraelCognitive Neurology Clinic and Department of Neurology, Beilinson Hospital, Petach Tikva, IsraelCognitive Neurology Institute, Rambam Health Care Campus, Haifa, IsraelCognitive Neurology Institute, Rambam Health Care Campus, Haifa, IsraelCognitive Neurology Institute, Rambam Health Care Campus, Haifa, IsraelSackler Faculty of Medicine, Tel Aviv University, Tel Aviv, IsraelCognitive Neurology Clinic and Department of Neurology, Beilinson Hospital, Petach Tikva, IsraelCharacterizing episodic memory abilities is highly important in the diagnosis of Alzheimer's disease (AD) and mild cognitive impairment (MCI), and usually includes wordlist learning and recall tasks. Clinical evaluations typically focus on the number of words recalled, ignoring additional information, like serial position. Here, we tested the potential value of two serial positioning measures for clinical diagnosis – how retrieval is initiated, as measured by the first word recalled, and how it proceeds – using data from patients with AD and MCI that completed a wordlist learning and recall task. Our results show that during the early stages of learning, patients with AD are less prone to retrieve the first word from the wordlist, manifested as lower primacy effect in the first word recalled, compared with MCI patients. The first word recalled measure adds to the differentiation between the groups over and above the total number of words learned. Thus, the first word recalled during word list learning and recall tasks may be used as a simple complementary measure to distinguish between MCI and AD during standard neuropsychological evaluations.https://www.frontiersin.org/articles/10.3389/fneur.2021.561824/fullmemoryneuropsychological testsAlzheimer diseasemild cognitive impairmentdifferential diagnosis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Irit Shapira-Lichter Irit Shapira-Lichter Noga Oren Anita Asvadurian Rachel Ben-Hayun Tali Fisher Judith Aharon-Peretz Amir Glik Amir Glik |
spellingShingle |
Irit Shapira-Lichter Irit Shapira-Lichter Noga Oren Anita Asvadurian Rachel Ben-Hayun Tali Fisher Judith Aharon-Peretz Amir Glik Amir Glik The First Word Recalled Measure – A Potential Addition to Clinical Exams Frontiers in Neurology memory neuropsychological tests Alzheimer disease mild cognitive impairment differential diagnosis |
author_facet |
Irit Shapira-Lichter Irit Shapira-Lichter Noga Oren Anita Asvadurian Rachel Ben-Hayun Tali Fisher Judith Aharon-Peretz Amir Glik Amir Glik |
author_sort |
Irit Shapira-Lichter |
title |
The First Word Recalled Measure – A Potential Addition to Clinical Exams |
title_short |
The First Word Recalled Measure – A Potential Addition to Clinical Exams |
title_full |
The First Word Recalled Measure – A Potential Addition to Clinical Exams |
title_fullStr |
The First Word Recalled Measure – A Potential Addition to Clinical Exams |
title_full_unstemmed |
The First Word Recalled Measure – A Potential Addition to Clinical Exams |
title_sort |
first word recalled measure – a potential addition to clinical exams |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Neurology |
issn |
1664-2295 |
publishDate |
2021-02-01 |
description |
Characterizing episodic memory abilities is highly important in the diagnosis of Alzheimer's disease (AD) and mild cognitive impairment (MCI), and usually includes wordlist learning and recall tasks. Clinical evaluations typically focus on the number of words recalled, ignoring additional information, like serial position. Here, we tested the potential value of two serial positioning measures for clinical diagnosis – how retrieval is initiated, as measured by the first word recalled, and how it proceeds – using data from patients with AD and MCI that completed a wordlist learning and recall task. Our results show that during the early stages of learning, patients with AD are less prone to retrieve the first word from the wordlist, manifested as lower primacy effect in the first word recalled, compared with MCI patients. The first word recalled measure adds to the differentiation between the groups over and above the total number of words learned. Thus, the first word recalled during word list learning and recall tasks may be used as a simple complementary measure to distinguish between MCI and AD during standard neuropsychological evaluations. |
topic |
memory neuropsychological tests Alzheimer disease mild cognitive impairment differential diagnosis |
url |
https://www.frontiersin.org/articles/10.3389/fneur.2021.561824/full |
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