Synthesis, crystal structure and anticancer activities of an unusual inorganic–organic hybrid complex with a sandwiched ribbon structure
An inorganic-organic hybrid complex [Cd7Cl14L2(EtOH)2]n (L = 4-Aminoantipyrine) was synthesised by solvothermal reaction and characterised by X-ray single-crystal diffraction analyses. It has unusual seven-nuclear cadmium chloride structure, which extends along the a-axis to form an infinite flat ri...
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2021-05-01
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| Series: | Arabian Journal of Chemistry |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1878535221001325 |
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doaj-0d941d7e01724b3885aa7bad4ff0a63e2021-04-30T07:21:05ZengElsevierArabian Journal of Chemistry1878-53522021-05-01145103117Synthesis, crystal structure and anticancer activities of an unusual inorganic–organic hybrid complex with a sandwiched ribbon structureJing Hu0Jiajia Qi1Yun Luo2Tianyue Yin3Jie Wang4Chunjing Wang5Wenge Li6Lili Liang7Department of Chemistry, Bengbu Medical College, Donghai Avenue, Bengbu 233030, Anhui, ChinaDepartment of Chemistry, Bengbu Medical College, Donghai Avenue, Bengbu 233030, Anhui, ChinaDepartment of Chemistry, Bengbu Medical College, Donghai Avenue, Bengbu 233030, Anhui, ChinaDepartment of Chemistry, Bengbu Medical College, Donghai Avenue, Bengbu 233030, Anhui, ChinaDepartment of Chemistry, Bengbu Medical College, Donghai Avenue, Bengbu 233030, Anhui, ChinaDepartment of Biological Sciences, Bengbu Medical College, Donghai Avenue, Bengbu 233030, Anhui, ChinaDepartment of Chemistry, Bengbu Medical College, Donghai Avenue, Bengbu 233030, Anhui, China; Corresponding authors.Department of Chemistry, Bengbu Medical College, Donghai Avenue, Bengbu 233030, Anhui, China; Corresponding authors.An inorganic-organic hybrid complex [Cd7Cl14L2(EtOH)2]n (L = 4-Aminoantipyrine) was synthesised by solvothermal reaction and characterised by X-ray single-crystal diffraction analyses. It has unusual seven-nuclear cadmium chloride structure, which extends along the a-axis to form an infinite flat ribbon structure with the thickness of 3 Å and the width of 18 Å. The flat inorganic ribbon is wrapped in the two edge sides by organic molecules to form a sandwich structure. The MTT assay result displayed that the synthesised complex possessed antiproliferative activity potentials against the HCT-116, HepG2 and MCF-7 cancer cell lines. After 72 h treatment, the complex had a potent inhibitory effect on HCT-116 cells, and the IC50 value was 1.05 ± 0.06 (μg/mL). The cell cycle and apoptosis experiments showed that the complex remarkably induced apoptosis and arrested the HCT-116 cancer cell lines in the G1/G0 phase related to the concentration.http://www.sciencedirect.com/science/article/pii/S1878535221001325Heptanuclear Cadmium complex4-AminoantipyrineSandwiched ribbonAntitumor activity |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Jing Hu Jiajia Qi Yun Luo Tianyue Yin Jie Wang Chunjing Wang Wenge Li Lili Liang |
| spellingShingle |
Jing Hu Jiajia Qi Yun Luo Tianyue Yin Jie Wang Chunjing Wang Wenge Li Lili Liang Synthesis, crystal structure and anticancer activities of an unusual inorganic–organic hybrid complex with a sandwiched ribbon structure Arabian Journal of Chemistry Heptanuclear Cadmium complex 4-Aminoantipyrine Sandwiched ribbon Antitumor activity |
| author_facet |
Jing Hu Jiajia Qi Yun Luo Tianyue Yin Jie Wang Chunjing Wang Wenge Li Lili Liang |
| author_sort |
Jing Hu |
| title |
Synthesis, crystal structure and anticancer activities of an unusual inorganic–organic hybrid complex with a sandwiched ribbon structure |
| title_short |
Synthesis, crystal structure and anticancer activities of an unusual inorganic–organic hybrid complex with a sandwiched ribbon structure |
| title_full |
Synthesis, crystal structure and anticancer activities of an unusual inorganic–organic hybrid complex with a sandwiched ribbon structure |
| title_fullStr |
Synthesis, crystal structure and anticancer activities of an unusual inorganic–organic hybrid complex with a sandwiched ribbon structure |
| title_full_unstemmed |
Synthesis, crystal structure and anticancer activities of an unusual inorganic–organic hybrid complex with a sandwiched ribbon structure |
| title_sort |
synthesis, crystal structure and anticancer activities of an unusual inorganic–organic hybrid complex with a sandwiched ribbon structure |
| publisher |
Elsevier |
| series |
Arabian Journal of Chemistry |
| issn |
1878-5352 |
| publishDate |
2021-05-01 |
| description |
An inorganic-organic hybrid complex [Cd7Cl14L2(EtOH)2]n (L = 4-Aminoantipyrine) was synthesised by solvothermal reaction and characterised by X-ray single-crystal diffraction analyses. It has unusual seven-nuclear cadmium chloride structure, which extends along the a-axis to form an infinite flat ribbon structure with the thickness of 3 Å and the width of 18 Å. The flat inorganic ribbon is wrapped in the two edge sides by organic molecules to form a sandwich structure. The MTT assay result displayed that the synthesised complex possessed antiproliferative activity potentials against the HCT-116, HepG2 and MCF-7 cancer cell lines. After 72 h treatment, the complex had a potent inhibitory effect on HCT-116 cells, and the IC50 value was 1.05 ± 0.06 (μg/mL). The cell cycle and apoptosis experiments showed that the complex remarkably induced apoptosis and arrested the HCT-116 cancer cell lines in the G1/G0 phase related to the concentration. |
| topic |
Heptanuclear Cadmium complex 4-Aminoantipyrine Sandwiched ribbon Antitumor activity |
| url |
http://www.sciencedirect.com/science/article/pii/S1878535221001325 |
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