Treatment with a Probiotic Mixture Containing <i>Bifidobacterium animalis</i> Subsp. <i>Lactis</i> BB12 and <i>Enterococcus faecium</i> L3 for the Prevention of Allergic Rhinitis Symptoms in Children: A Randomized Controlled Trial
Background: Probiotics may prevent the allergic response development due to their anti-inflammatory and immunomodulatory effects. The aim of this study is to determine if the prophylactic treatment with a mixture of <i>Bifidobacterium animalis</i> subsp. <i>Lactis</i> BB12 an...
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doaj-0d94709428a546b7af65f3aef8f5da002021-04-16T23:02:27ZengMDPI AGNutrients2072-66432021-04-01131315131510.3390/nu13041315Treatment with a Probiotic Mixture Containing <i>Bifidobacterium animalis</i> Subsp. <i>Lactis</i> BB12 and <i>Enterococcus faecium</i> L3 for the Prevention of Allergic Rhinitis Symptoms in Children: A Randomized Controlled TrialCaterina Anania0Vincenza Patrizia Di Marino1Francesca Olivero2Daniela De Canditiis3Giulia Brindisi4Federico Iannilli5Giovanna De Castro6Anna Maria Zicari7Marzia Duse8Immunology and Allergology Unit, Department of Mother-Child, Urological Science, Sapienza University of Rome, 00161 Rome, ItalyImmunology and Allergology Unit, Department of Mother-Child, Urological Science, Sapienza University of Rome, 00161 Rome, ItalyPediatric Clinic, Department of Pediatrics, Fondazione IRCSS Policlinico San Matteo, University of Pavia, 27100 Pavia, ItalyInstitute of Applied Calculus-CNR Rome, 00185 Rome, ItalyImmunology and Allergology Unit, Department of Mother-Child, Urological Science, Sapienza University of Rome, 00161 Rome, ItalyImmunology and Allergology Unit, Department of Mother-Child, Urological Science, Sapienza University of Rome, 00161 Rome, ItalyImmunology and Allergology Unit, Department of Mother-Child, Urological Science, Sapienza University of Rome, 00161 Rome, ItalyImmunology and Allergology Unit, Department of Mother-Child, Urological Science, Sapienza University of Rome, 00161 Rome, ItalyImmunology and Allergology Unit, Department of Mother-Child, Urological Science, Sapienza University of Rome, 00161 Rome, ItalyBackground: Probiotics may prevent the allergic response development due to their anti-inflammatory and immunomodulatory effects. The aim of this study is to determine if the prophylactic treatment with a mixture of <i>Bifidobacterium animalis</i> subsp. <i>Lactis</i> BB12 and <i>Enterococcus faecium</i> L3 would reduce symptoms and need for drug use in children with allergic rhinitis (AR). Methods: The study included 250 children aged from 6 to 17 years, affected by AR. Patients were randomly assigned to the intervention group (150) or to the placebo group (100). Patients in the intervention group, in addition to conventional therapy (local corticosteroids and/or oral antihistamines), were treated in the 3 months preceding the onset of symptoms related to the presence of the allergen to which the children were most sensitized, with a daily oral administration of a probiotic mixture containing the <i>Bifidobacterium animalis</i> subsp. <i>Lactis</i> BB12 DSM 15954 and the <i>Enterococcus faecium</i> L3 LMG P-27496 strain. We used Nasal Symptoms Score (NSS) to evaluate AR severity before and after the treatment with probiotics or placebo. Results: the patients in the intervention group had a significant reduction in their NSS after probiotic treatment (<i>p</i>-value = 2.2 × 10<sup>−10</sup>. Moreover, for the same group of patients, we obtained a significant reduction in the intake of pharmacological therapy. In particular, we obtained a reduction in the use of oral antihistamines (<i>p</i>-value = 2.2 × 10<sup>−16</sup>), local corticosteroids (<i>p</i>-value = 2.2 × 10<sup>−13</sup>), and of both drugs (<i>p</i>-value 1.5 × 10<sup>−15</sup>). Conclusions: When administered as a prophylactic treatment, a mixture of BB12 and L3 statistically decreased signs and symptoms of AR and reduced significantly the need of conventional therapy.https://www.mdpi.com/2072-6643/13/4/1315allergic rhinitisprobiotics<i>Bifidobacterium animalis</i> subsp. <i>Lactis</i> BB12<i>Enterococcus faecium L3</i>children |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Caterina Anania Vincenza Patrizia Di Marino Francesca Olivero Daniela De Canditiis Giulia Brindisi Federico Iannilli Giovanna De Castro Anna Maria Zicari Marzia Duse |
spellingShingle |
Caterina Anania Vincenza Patrizia Di Marino Francesca Olivero Daniela De Canditiis Giulia Brindisi Federico Iannilli Giovanna De Castro Anna Maria Zicari Marzia Duse Treatment with a Probiotic Mixture Containing <i>Bifidobacterium animalis</i> Subsp. <i>Lactis</i> BB12 and <i>Enterococcus faecium</i> L3 for the Prevention of Allergic Rhinitis Symptoms in Children: A Randomized Controlled Trial Nutrients allergic rhinitis probiotics <i>Bifidobacterium animalis</i> subsp. <i>Lactis</i> BB12 <i>Enterococcus faecium L3</i> children |
author_facet |
Caterina Anania Vincenza Patrizia Di Marino Francesca Olivero Daniela De Canditiis Giulia Brindisi Federico Iannilli Giovanna De Castro Anna Maria Zicari Marzia Duse |
author_sort |
Caterina Anania |
title |
Treatment with a Probiotic Mixture Containing <i>Bifidobacterium animalis</i> Subsp. <i>Lactis</i> BB12 and <i>Enterococcus faecium</i> L3 for the Prevention of Allergic Rhinitis Symptoms in Children: A Randomized Controlled Trial |
title_short |
Treatment with a Probiotic Mixture Containing <i>Bifidobacterium animalis</i> Subsp. <i>Lactis</i> BB12 and <i>Enterococcus faecium</i> L3 for the Prevention of Allergic Rhinitis Symptoms in Children: A Randomized Controlled Trial |
title_full |
Treatment with a Probiotic Mixture Containing <i>Bifidobacterium animalis</i> Subsp. <i>Lactis</i> BB12 and <i>Enterococcus faecium</i> L3 for the Prevention of Allergic Rhinitis Symptoms in Children: A Randomized Controlled Trial |
title_fullStr |
Treatment with a Probiotic Mixture Containing <i>Bifidobacterium animalis</i> Subsp. <i>Lactis</i> BB12 and <i>Enterococcus faecium</i> L3 for the Prevention of Allergic Rhinitis Symptoms in Children: A Randomized Controlled Trial |
title_full_unstemmed |
Treatment with a Probiotic Mixture Containing <i>Bifidobacterium animalis</i> Subsp. <i>Lactis</i> BB12 and <i>Enterococcus faecium</i> L3 for the Prevention of Allergic Rhinitis Symptoms in Children: A Randomized Controlled Trial |
title_sort |
treatment with a probiotic mixture containing <i>bifidobacterium animalis</i> subsp. <i>lactis</i> bb12 and <i>enterococcus faecium</i> l3 for the prevention of allergic rhinitis symptoms in children: a randomized controlled trial |
publisher |
MDPI AG |
series |
Nutrients |
issn |
2072-6643 |
publishDate |
2021-04-01 |
description |
Background: Probiotics may prevent the allergic response development due to their anti-inflammatory and immunomodulatory effects. The aim of this study is to determine if the prophylactic treatment with a mixture of <i>Bifidobacterium animalis</i> subsp. <i>Lactis</i> BB12 and <i>Enterococcus faecium</i> L3 would reduce symptoms and need for drug use in children with allergic rhinitis (AR). Methods: The study included 250 children aged from 6 to 17 years, affected by AR. Patients were randomly assigned to the intervention group (150) or to the placebo group (100). Patients in the intervention group, in addition to conventional therapy (local corticosteroids and/or oral antihistamines), were treated in the 3 months preceding the onset of symptoms related to the presence of the allergen to which the children were most sensitized, with a daily oral administration of a probiotic mixture containing the <i>Bifidobacterium animalis</i> subsp. <i>Lactis</i> BB12 DSM 15954 and the <i>Enterococcus faecium</i> L3 LMG P-27496 strain. We used Nasal Symptoms Score (NSS) to evaluate AR severity before and after the treatment with probiotics or placebo. Results: the patients in the intervention group had a significant reduction in their NSS after probiotic treatment (<i>p</i>-value = 2.2 × 10<sup>−10</sup>. Moreover, for the same group of patients, we obtained a significant reduction in the intake of pharmacological therapy. In particular, we obtained a reduction in the use of oral antihistamines (<i>p</i>-value = 2.2 × 10<sup>−16</sup>), local corticosteroids (<i>p</i>-value = 2.2 × 10<sup>−13</sup>), and of both drugs (<i>p</i>-value 1.5 × 10<sup>−15</sup>). Conclusions: When administered as a prophylactic treatment, a mixture of BB12 and L3 statistically decreased signs and symptoms of AR and reduced significantly the need of conventional therapy. |
topic |
allergic rhinitis probiotics <i>Bifidobacterium animalis</i> subsp. <i>Lactis</i> BB12 <i>Enterococcus faecium L3</i> children |
url |
https://www.mdpi.com/2072-6643/13/4/1315 |
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