TMEM135 is a Novel Regulator of Mitochondrial Dynamics and Physiology with Implications for Human Health Conditions

TMEM135 is a Novel Regulator of Mitochondrial Dynamics and Physiology with Implications for Human Health Conditions

Transmembrane proteins (TMEMs) are integral proteins that span biological membranes. TMEMs function as cellular membrane gates by modifying their conformation to control the influx and efflux of signals and molecules. TMEMs also reside in and interact with the membranes of various intracellular orga...

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Bibliographic Details
Main Authors: Heather K. Beasley, Taylor A. Rodman, Greg V. Collins, Antentor Hinton, Vernat Exil
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Cells
Subjects:
TMEM135
fission
mitochondrial dynamics
aging
Online Access:https://www.mdpi.com/2073-4409/10/7/1750
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spelling doaj-0da1621ec5ec4d138a9f50bcf5e8e5572021-07-23T13:35:04ZengMDPI AGCells2073-44092021-07-01101750175010.3390/cells10071750TMEM135 is a Novel Regulator of Mitochondrial Dynamics and Physiology with Implications for Human Health ConditionsHeather K. Beasley0Taylor A. Rodman1Greg V. Collins2Antentor Hinton3Vernat Exil4Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN 37232, USADepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN 37232, USAFraternal Order of Eagles Diabetes Research Center, Iowa City, IA 52242, USADepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN 37232, USAFraternal Order of Eagles Diabetes Research Center, Iowa City, IA 52242, USATransmembrane proteins (TMEMs) are integral proteins that span biological membranes. TMEMs function as cellular membrane gates by modifying their conformation to control the influx and efflux of signals and molecules. TMEMs also reside in and interact with the membranes of various intracellular organelles. Despite much knowledge about the biological importance of TMEMs, their role in metabolic regulation is poorly understood. This review highlights the role of a single TMEM, transmembrane protein 135 (TMEM135). TMEM135 is thought to regulate the balance between mitochondrial fusion and fission and plays a role in regulating lipid droplet formation/tethering, fatty acid metabolism, and peroxisomal function. This review highlights our current understanding of the various roles of TMEM135 in cellular processes, organelle function, calcium dynamics, and metabolism.https://www.mdpi.com/2073-4409/10/7/1750TMEM135fissionmitochondrial dynamicsaging
collection DOAJ
language English
format Article
sources DOAJ
author Heather K. Beasley
Taylor A. Rodman
Greg V. Collins
Antentor Hinton
Vernat Exil
spellingShingle Heather K. Beasley
Taylor A. Rodman
Greg V. Collins
Antentor Hinton
Vernat Exil
TMEM135 is a Novel Regulator of Mitochondrial Dynamics and Physiology with Implications for Human Health Conditions
Cells
TMEM135
fission
mitochondrial dynamics
aging
author_facet Heather K. Beasley
Taylor A. Rodman
Greg V. Collins
Antentor Hinton
Vernat Exil
author_sort Heather K. Beasley
title TMEM135 is a Novel Regulator of Mitochondrial Dynamics and Physiology with Implications for Human Health Conditions
title_short TMEM135 is a Novel Regulator of Mitochondrial Dynamics and Physiology with Implications for Human Health Conditions
title_full TMEM135 is a Novel Regulator of Mitochondrial Dynamics and Physiology with Implications for Human Health Conditions
title_fullStr TMEM135 is a Novel Regulator of Mitochondrial Dynamics and Physiology with Implications for Human Health Conditions
title_full_unstemmed TMEM135 is a Novel Regulator of Mitochondrial Dynamics and Physiology with Implications for Human Health Conditions
title_sort tmem135 is a novel regulator of mitochondrial dynamics and physiology with implications for human health conditions
publisher MDPI AG
series Cells
issn 2073-4409
publishDate 2021-07-01
description Transmembrane proteins (TMEMs) are integral proteins that span biological membranes. TMEMs function as cellular membrane gates by modifying their conformation to control the influx and efflux of signals and molecules. TMEMs also reside in and interact with the membranes of various intracellular organelles. Despite much knowledge about the biological importance of TMEMs, their role in metabolic regulation is poorly understood. This review highlights the role of a single TMEM, transmembrane protein 135 (TMEM135). TMEM135 is thought to regulate the balance between mitochondrial fusion and fission and plays a role in regulating lipid droplet formation/tethering, fatty acid metabolism, and peroxisomal function. This review highlights our current understanding of the various roles of TMEM135 in cellular processes, organelle function, calcium dynamics, and metabolism.
topic TMEM135
fission
mitochondrial dynamics
aging
url https://www.mdpi.com/2073-4409/10/7/1750
work_keys_str_mv AT heatherkbeasley tmem135isanovelregulatorofmitochondrialdynamicsandphysiologywithimplicationsforhumanhealthconditions
AT taylorarodman tmem135isanovelregulatorofmitochondrialdynamicsandphysiologywithimplicationsforhumanhealthconditions
AT gregvcollins tmem135isanovelregulatorofmitochondrialdynamicsandphysiologywithimplicationsforhumanhealthconditions
AT antentorhinton tmem135isanovelregulatorofmitochondrialdynamicsandphysiologywithimplicationsforhumanhealthconditions
AT vernatexil tmem135isanovelregulatorofmitochondrialdynamicsandphysiologywithimplicationsforhumanhealthconditions
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