TMEM135 is a Novel Regulator of Mitochondrial Dynamics and Physiology with Implications for Human Health Conditions
Transmembrane proteins (TMEMs) are integral proteins that span biological membranes. TMEMs function as cellular membrane gates by modifying their conformation to control the influx and efflux of signals and molecules. TMEMs also reside in and interact with the membranes of various intracellular orga...
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doaj-0da1621ec5ec4d138a9f50bcf5e8e5572021-07-23T13:35:04ZengMDPI AGCells2073-44092021-07-01101750175010.3390/cells10071750TMEM135 is a Novel Regulator of Mitochondrial Dynamics and Physiology with Implications for Human Health ConditionsHeather K. Beasley0Taylor A. Rodman1Greg V. Collins2Antentor Hinton3Vernat Exil4Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN 37232, USADepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN 37232, USAFraternal Order of Eagles Diabetes Research Center, Iowa City, IA 52242, USADepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN 37232, USAFraternal Order of Eagles Diabetes Research Center, Iowa City, IA 52242, USATransmembrane proteins (TMEMs) are integral proteins that span biological membranes. TMEMs function as cellular membrane gates by modifying their conformation to control the influx and efflux of signals and molecules. TMEMs also reside in and interact with the membranes of various intracellular organelles. Despite much knowledge about the biological importance of TMEMs, their role in metabolic regulation is poorly understood. This review highlights the role of a single TMEM, transmembrane protein 135 (TMEM135). TMEM135 is thought to regulate the balance between mitochondrial fusion and fission and plays a role in regulating lipid droplet formation/tethering, fatty acid metabolism, and peroxisomal function. This review highlights our current understanding of the various roles of TMEM135 in cellular processes, organelle function, calcium dynamics, and metabolism.https://www.mdpi.com/2073-4409/10/7/1750TMEM135fissionmitochondrial dynamicsaging |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Heather K. Beasley Taylor A. Rodman Greg V. Collins Antentor Hinton Vernat Exil |
spellingShingle |
Heather K. Beasley Taylor A. Rodman Greg V. Collins Antentor Hinton Vernat Exil TMEM135 is a Novel Regulator of Mitochondrial Dynamics and Physiology with Implications for Human Health Conditions Cells TMEM135 fission mitochondrial dynamics aging |
author_facet |
Heather K. Beasley Taylor A. Rodman Greg V. Collins Antentor Hinton Vernat Exil |
author_sort |
Heather K. Beasley |
title |
TMEM135 is a Novel Regulator of Mitochondrial Dynamics and Physiology with Implications for Human Health Conditions |
title_short |
TMEM135 is a Novel Regulator of Mitochondrial Dynamics and Physiology with Implications for Human Health Conditions |
title_full |
TMEM135 is a Novel Regulator of Mitochondrial Dynamics and Physiology with Implications for Human Health Conditions |
title_fullStr |
TMEM135 is a Novel Regulator of Mitochondrial Dynamics and Physiology with Implications for Human Health Conditions |
title_full_unstemmed |
TMEM135 is a Novel Regulator of Mitochondrial Dynamics and Physiology with Implications for Human Health Conditions |
title_sort |
tmem135 is a novel regulator of mitochondrial dynamics and physiology with implications for human health conditions |
publisher |
MDPI AG |
series |
Cells |
issn |
2073-4409 |
publishDate |
2021-07-01 |
description |
Transmembrane proteins (TMEMs) are integral proteins that span biological membranes. TMEMs function as cellular membrane gates by modifying their conformation to control the influx and efflux of signals and molecules. TMEMs also reside in and interact with the membranes of various intracellular organelles. Despite much knowledge about the biological importance of TMEMs, their role in metabolic regulation is poorly understood. This review highlights the role of a single TMEM, transmembrane protein 135 (TMEM135). TMEM135 is thought to regulate the balance between mitochondrial fusion and fission and plays a role in regulating lipid droplet formation/tethering, fatty acid metabolism, and peroxisomal function. This review highlights our current understanding of the various roles of TMEM135 in cellular processes, organelle function, calcium dynamics, and metabolism. |
topic |
TMEM135 fission mitochondrial dynamics aging |
url |
https://www.mdpi.com/2073-4409/10/7/1750 |
work_keys_str_mv |
AT heatherkbeasley tmem135isanovelregulatorofmitochondrialdynamicsandphysiologywithimplicationsforhumanhealthconditions AT taylorarodman tmem135isanovelregulatorofmitochondrialdynamicsandphysiologywithimplicationsforhumanhealthconditions AT gregvcollins tmem135isanovelregulatorofmitochondrialdynamicsandphysiologywithimplicationsforhumanhealthconditions AT antentorhinton tmem135isanovelregulatorofmitochondrialdynamicsandphysiologywithimplicationsforhumanhealthconditions AT vernatexil tmem135isanovelregulatorofmitochondrialdynamicsandphysiologywithimplicationsforhumanhealthconditions |
_version_ |
1721288963483762688 |